N-(1-Phenylpyrazol-3-yl)-N-[1-(2-phenylethyl)-4-piperidyl]propanamide
The oxalate salts and free bases of fentanyl and
N-[1-(2-phenylethyl)-4-piperidyl]-N-(1-phenyl-4-pyrazolyl)propanamide, a
new lead compound for long-acting analgesia, have been characterized by
(1)H- and (13)C-NMR spectroscopy. The crystal structure of the
hydrochloride of
N-[1-(2-phenylethyl)-4-piperidyl]-N-(1-phenyl-4-pyrazolyl)propanamide
monohydrate has been determined.
N-Phenyl-N-(4-piperidinyl)propanamide HCL
Two centrosymmetrically related cations, joined through C(phenyl)-H
em leader pi contacts, encapsulate a large void that contains pairs of
anions and bridged water molecules into a zero-dimensional (0D)
supramolecular motif. The cations are linked to this framework via N(+)H
em leader Cl(-) contacts. GIAO/B3LYP calculations have been carried out
to compare the experimental (13)C chemical shifts with the absolute
shieldings thus calculated. The protonation of both molecules takes
place on the piperidine ring (axial protonation), as has been verified
both in the solid state (X-ray) and in solution (NMR).
The Wall