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Absrtact Bremelanotide (formerly PT-141) is a compound under drug
development by Palatin Technologies as a treatment for female sexual
dysfunction, hemorrhagic shock and reperfusion injury. It functions by
activating the melanocortin receptors MC1R and MC4R, to modulate
inflammation and limitingischemia. It was originally tested for
intranasal administration in treating female sexual dysfunctionbut this
application was temporarily discontinued in 2008 after concerns were
raised over adverse side effects of increased blood pressure. As of
March, 2012, Palatin is conducting a human Phase 2B study using a new
subcutaneous drug delivery system that appears to have little effect on
blood pressure.
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