NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic
research chemical created by Neuralstem, Inc. that was derived from
pyrazine and nicotinamide. Studies have shown that it stimulates
neurogenesis of human hippocampus-derived neural stem cells in vivo and
vitro . In healthy adult mice, NSI-189 has been shown to increase the
hippocampal volume by 20% and reverse behavioral symptoms in mouse
depression models, meaning at the source it could address depression .
The hippocampus is responsible for spatial navigation, along with the
consolidation of information from short-term memory to long-term memory.
NSI-189 base powder
The chemical entity stimulates new neuron growth in the hippocampus,
which is an area of the brain that is believed to be contributory in
conditions such as post-traumatic stress disorder (PTSD), Alzheimer's
disease, and major depressive disorder (MDD).
NSI-189's Method of Action:
Although it has been demonstrated in rats and chimps, the suggestion
that having too small of a hippocampus causes depression and other
diseases in humans is still technically just a theory. NSI-189 increases
hippocampal volume in adult mice by 20%, a region of the brain that is
one of the first to suffer damage resulting in memory loss,
disorientation, encephalitis, and hypoxia from disease's such as
Alzheimer's .
Nsi-189 Effect
1) Enhance cognition and memory formation.
2) Anxiolytic properties.
3) Anti-depressive effect .
4) Treatment of Alzheimer's and Parkinson's disease.
5) Increase coordination.
6) Improves mood.
7) Help fight fatigue.
8) Prevent oxidation within the brain.
9) Treat alcohol related brain damage.
The Wall