Antioxidant Ability and Stability Studies of 3-O-Ethyl Ascorbic Acid
3-O-Ethyl-L-Ascorbic Acid, or Ethyl Ascorbic Acid is a molecule
produced by modifying Ascorbic Acid, commonly known as Vitamin C. This
modification is done to increase the molecule’s stability and enhance
its transport through skin, as pure Vitamin C is easily degraded. In the
body, the modifying group is removed and Vitamin C is restored in its
natural form. Thus, Ethyl Ascorbic Acid retains the benefits of Vitamin
C, such as antioxidant activity. Furthermore, it is even more potent in
reducing skin darkening after UV exposure. It even has some additional
effects, not observed in pure Ascorbic Acid, such as promoting nerve
cell growth or reducing chemotherapy damage. Finally, the slower release
also ensures that no toxic effects are observed when using this Vitamin
C derivative.
3-O-Ethyl-L-Ascorbic Acid
3- O -ethyl ascorbic acid may be a good whitening ingredient in
cosmetics. However, before it can be successfully used in cosmetics, its
biofunctionality and stability need to be comprehensively investigated.
The reduction and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical
scavenging ability of this compound were analyzed to assess its
antioxidant potential. In addition, the tyrosinase inhibitory ability
was analyzed to show the whitening capacity of 3- O -ethyl ascorbic
acid. Response surface methodology (RSM) was used to determine the
optimal conditions for the ascorbic acid derivative in cosmetics. Based
on the DPPH radical scavenging ability results, the half-inhibitory
concentration (IC 50 ) value of 3- O -ethyl ascorbic acid was 0.032 g/L.
It also showed a good reducing ability at 1.5 g/L concentration. Based
on the tyrosinase inhibition analysis, the IC 50 value was 7.5 g/L. The
opti
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