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Six police officers who speak English, Japanese and Korean are at the service of foreign visitors at three Metro stations near the site of the second China International Import Expo.The second China International Import Expo will be held at the National Exhibition and Convention Center in Shanghai from November 5 to 10, 2019.For further information about China International Import Expo, please visit: https://www.shine.cn/China-International-Import-Expo/ or
https://www.shine.cn/ciie2019/v1.To get more ciie shanghai 2019 dates, you can visit shine news official website.

One of them is Xu Wenyi, who speaks English and Japanese. She works at East Xujing Station on Line 2 and can be found at Exits 4, 5 or 6.Xu said both Chinese and foreigners make inquiries about directions when arriving at the station.

“Many foreigners are not sure if they can get help from us. When I spot someone looking hesitant, I’ll come up to help,” she said.

Xu, who has been working as a police officer for nine years, normally works at the People’s Square Metro Station. Like many of her colleagues, she was assigned to work at East Xujing only for the expo, which is visited by hundreds of thousands of people.

With her knowledge of Japanese, she also provides translation support when Japanese speakers call police at the emergency number 110.

Xu is no stranger to big crowds at Metro stations. She said that People’s Square Station during the Chinese National Day holiday can be even more crowded.

Xu has two colleagues who speak foreign languages at East Xujing Station, while three other multilingual officers can be found at Zhuguang Road Station on Line 17 and the station of Hongqiao Railway Station on Lines 2, 10 and 17.

About 380 police officers and their assistants are working at the Metro stations of East Xujing, Zhuguang Road and Hongqiao Railway Station during the expo. The three stations typically have less than 20 police officers and assistants.

A promotion meeting on trade in services for the Belt and Road regions, an important supplement of the second China International Import Expo, was held on Thursday.The second China International Import Expo will be held at the National Exhibition and Convention Center in Shanghai from November 5 to 10, 2019.For further information about China International Import Expo, please visit: https://www.shine.cn/China-International-Import-Expo/ or
https://www.shine.cn/ciie2019/v1.To get more ciie china 2019, you can visit shine news official website.


The meeting aimed to acquaint participating enterprises with the latest policies on trade in services, offer them a chance to showcase their major service trade projects, and served as a platform for domestic and foreign companies to build connections.

Trade in services is playing an increasingly important role in the world's economy and has become a new source of momentum for the development of foreign trade, said Shanghai vice mayor Xu Kunlin.

"Openness is the biggest advantage of Shanghai, and the opening up of the service sector is among the top priorities," Xu said.

In 2018, the city's total foreign service trade approximated US$200 billion in total. This year, Shanghai issued 40 new measures for a new round of opening up in the service sector in August.

The city's Commission of Commerce has in recent years compiled a series of reports on service trade development and guidelines for key overseas markets, introducing countries along the Belt and Road.

The reports help Chinese service enterprises to strengthen cooperation with these regions and to seize business opportunities in the Belt and Road areas.

At today's meeting, such a report for the United Arab Emirates was officially released, providing a comprehensive overview of the UAE's trade in services.

Nearly 400 representatives of government authorities and businesses from thirteen countries (Belarus, Tajikistan, Kyrgyzstan, Russia, Turkmenistan, Ukraine, Germany, Mongolia, Nepal, Bangladesh, Kenya, Colombia, Barbados) attended the meeting.

This introductory course is designed to acquaint students with the basic elements of film production. Students are taught the aesthetics and techniques required for producing a short narrative film. They are also introduced to techniques in producing, writing, cinematography, directing, and editing. Students are required to write, produce, and direct a short film. Note: Students are required to share in the expenses involved in their productions.wisepoqder CMS121
Course Goals: Upon successful completion of this course, students should be able to do the following:
develop a storyboard and script for a short film from an original idea;
utilize cinematographic techniques to convey meaning and create visual interest in a short film;
plan and implement a film shoot with a variety of crew roles; and
edit filmed scenes into a short narrative or experimental film.

This Phase I clinical study will assess the safety and pharmacokinetics of the experimental drug J147 in healthy adults. Researchers are investigating the drug as a potential treatment for Alzheimer's disease.wisepoqder J147 powder

Exclusion Criteria
History or evidence of heart, endocrine, blood, immune, gastrointestinal, genital, urinary, or other body system disease
History or evidence of disease or dysfunction in neurological or psychiatric system that is likely to affect study results
Any disorder that would interfere with the absorption, distribution, metabolism, or excretion of drugs
Any concurrent disease or condition that would make the participant unsuitable for study participation
Positive for hepatitis B surface antigen, hepatitis C antibody, or HIV antibodies
Positive test for ethanol (alcohol) or cotinine (tobacco) at screening or admission
Positive urine drug test (e.g., cocaine, amphetamines, barbiturates, opiates, benzodiazepines, cannabinoids) at screening or admission
Is unwilling to avoid consumption of grapefruit, Seville oranges, or other products containing grapefruit or Seville oranges within 14 days of taking the study drug
History of alcohol and/or illicit drug abuse in past year or is unwilling to avoid use of alcohol or alcohol-containing foods, medications, or beverages within 48 hours of admission until discharge from the clinical unit
Has donated blood or blood products within 30 days of first dosing
Requires treatment with any prescription drugs or over-the-counter medications, including vitamins (large doses), dietary supplements, or herbal medications, within 14 days of study medication (acetaminophen 1,000 mg per day and recommended daily doses of vitamins are permitted)
Has received any known liver or kidney clearance altering agents (e.g., erythromycin, cimetidine, barbiturates, phenothiazines, or St. John's wort) within 30 days of study start
Has used an investigational drug within 30 days of screening
Hypersensitivity or allergies to J147, any of its components, or any drug within the same class
Significant abnormal vital signs on physical exam or laboratory results
Is considering or has scheduled any surgical procedure during study participation
Requires a special diet or has a significant food allergy or intolerance (vegetarian diet may be permitted)
Currently enrolled in another clinical study
Evidence of cognitive decline that is greater than expected for participant's age or changes in level of independence in everyday life
Detailed Description
J147 is a synthetic derivative of curcumin, a component of the curry spice turmeric. In this study participants will be randomly assigned to take either the study drug or a placebo in an escalating dose. Doses will first be given to younger participants after an 8-hour fast. Older participants will then receive doses that have been found to be safe in younger participants.

Alpha-lipoic acid has gained a lot of attention in recent years.It’s an organic compound that acts as a powerful antioxidant in the body.Your body produces alpha-lipoic acid naturally, but it’s also found in a variety of foods and as a dietary supplement.Research suggests that it may play a role in weight loss, diabetes, and other health conditions.

However, many people wonder whether it’s effective.This article reviews alpha-lipoic acid, its benefits, side effects, and recommended dosage.wisepoqder Alpha-lipoic Acid
What is alpha-lipoic acid?
Alpha-lipoic acid is an organic compound found in all human cells.It’s made inside the mitochondrion — also known as the powerhouse of cells — where it helps enzymes turn nutrients into energy (1).What’s more, it has powerful antioxidant properties.

Alpha-lipoic acid is both water- and fat-soluble, which allows it to work in every cell or tissue in the body. Meanwhile, most other antioxidants are either water- or fat-soluble (2).For instance, vitamin C is only water-soluble, while vitamin E is only fat-soluble.

The antioxidant properties of alpha-lipoic acid have been linked to several benefits, including lower blood sugar levels, reduced inflammation, slowed skin aging, and improved nerve function.Humans only produce alpha-lipoic acid in small amounts. That’s why many turn to certain foods or supplements to optimize their intake.

Animal products like red meat and organ meats are great sources of alpha-lipoic acid, but plant foods like broccoli, tomatoes, spinach, and Brussels sprouts also contain it.That said, supplements can pack up to 1,000 times more alpha-lipoic acid than food sources (3).
Alpha-lipoic acid and weight loss
Research has shown that alpha-lipoic acid may affect weight loss in several ways.Animal studies indicate that it can reduce the activity of the enzyme AMP-activated protein kinase (AMPK), which is located in your brain’s hypothalamus (4, 5).

When AMPK is more active, it may increase feelings of hunger.On the other hand, suppressing AMPK activity may increase the number of calories your body burns at rest. Thus, animals who took alpha-lipoic acid burned more calories (6, 7).

However, human studies show that alpha-lipoic acid only slightly impacts weight loss.An analysis of 12 studies discovered that people who took an alpha-lipoic acid supplement lost an average of 1.52 pounds (0.69 kg) more than those taking a placebo over an average of 14 weeks (8).In the same analysis, alpha-lipoic acid did not significantly affect waist circumference.

Another analysis of 12 studies found that people who took alpha-lipoic acid lost an average of 2.8 pounds (1.27 kg) more than those taking a placebo over an average of 23 weeks (9).In short, it seems that alpha-lipoic acid has just a slight effect on weight loss in humans.

Alpha-lipoic acid or ALA is a naturally occurring compound that's made in the body. It serves vital functions at the cellular level, such as energy production. As long as you're healthy, the body can produce all the ALA it needs for these purposes. Despite that fact, there has been a lot of recent interest in using ALA supplements. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss.wisepoqder Alpha-lipoic Acid powder

Research on the effects of ALA supplementation is sparse. What there is, though, does suggest some possible benefits. Here is what's known about the potential health benefits of using alpha-lipoic acid supplements.
ALA is an antioxidant. Antioxidants protect against damage to the body's cells.

There are food sources of ALA such as yeast, organ meats like liver and heart, spinach, broccoli, and potatoes. However, ALA from food does not appear to produce a noticeable increase in the level of free ALA in the body.Some people take ALA supplements with the intent to improve a variety of health conditions. Scientific evidence for the health benefit of supplemental ALA has been inconclusive.

Studies show that about 30% to 40% of the oral dose of an ALA supplement is absorbed. ALA may be better absorbed if it is taken on an empty stomach.

While studies are still sparse, there is some evidence that ALA may have at least two positive benefits for individuals with type 2 diabetes. A few studies have suggested that alpha-lipoic acid supplements may enhance the body's ability to use its own insulin to lower blood sugar in people with type 2 diabetes. ALA may help reduce the symptoms of peripheral neuropathy -- nerve damage that can be caused by diabetes.

In Europe, ALA has been used for years to provide relief from the pain, burning, tingling, and numbing caused by diabetic neuropathy. In particular, one large study strongly suggested that large intravenous doses of ALA were effective at relieving symptoms. But the evidence for oral doses is not as strong. More research is needed to establish the effectiveness of oral ALA supplements for diabetic neuropathy.

L-arginine, an amino acid, is found in foods like dairy products and meats. It helps in bodybuilding, muscle development, and improved performance.

These benefits have been researched with most conclusions being made after extensive studies.One study showed that L-arginine improves DNA synthesis and mitochondrial bioenergetics, which may also be responsible for the beneficial effects of Arg on intestinal mucosal cells.wisepoqder L(+)-Arginine

L-arginine is produced by the body in adequate amounts to elevate the action of a nitric acid in the body. It also has biochemical components that enhance the metabolism of fats.It is mostly given to people dealing with obesity to help burn the fat and enhance the formation of muscle mass. Supplementing with l-arginine allows your body to use accumulated fats as a source of energy.

The accumulated fat is burnt to produce energy and to aid in muscle mass formation and development. L-arginine thus boosts your body metabolism as well as forms building blocks for muscle formation.As a result, you lose fat mass but retain your muscle mass.

To test the efficacy of l-arginine on weight loss, a research study was conducted. L-arginine supplements were given to obese males who had type 2 diabetes to see if it would help in weight loss.

The study had more than 300 subjects who were subjected to the l-arginine and placebo groups.They consumed 1000kcal per day and exercised 90 minutes every day for five days in a week. They also took 8.3g of l-arginine per day.

The results from the 21-day study showed that l-arginine increases weight loss. People who got l-arginine showed that 100 percent of the weight loss was all fat compared to those on placebo who lost up to 40 percent muscle mass.

Larger doses of l-arginine for weight loss allow for faster fat burning, which is needed in the development of a leaner body:
The upper recommended l-arginine amount per serving is 5 to 10 grams. You should start with a lower serving and increase the dosage as you continue to use the supplement. It stimulates more body fat burning and formation of muscle, thus making it ideal for people looking to lose weight.

This supplement is highly effective in the treatment of obesity. However, excessive use can lead to harmful side effects.Amino acids are known to aid in bodybuilding. For instance, l-arginine minimizes the action of the adipose tissue, which is the belly fat. Obesity is mainly characterized by stores of belly fat. The more a person accumulates the belly fat, the higher the risk of developing cardiovascular diseases.

Stimulates production of HGH
L-arginine also increases the levels of HGH (Human Growth Hormone) that supports increased metabolism. However, it increases HGH levels when taken in very large amounts. Taking large amounts of the supplement is not advisable, however, because it can cause side effects such as stomach cramps and diarrhea.

Increased energy:
Additionally, l-arginine is an ingredient long used in supplement formulas. It has been used for a wide range of functions including the enhancement of sports performance and boosting cardiovascular health. Since it is a nitrogenous acid, it stimulates the production of a nitric oxide whose making function is to dilate the blood vessels. Increased blood flow through the body increases energy and enhances the overall body performance.
Dilated vessels ease the work of the heart, thus improving your cardiovascular health by lowering your blood pressure. They also transport blood faster to different pressure points, which increases your energy for workouts.

Besides increasing your energy, dilated blood vessels also act as a treatment basis for erectile dysfunction.Some studies have pointed out that it increases semen production, implying that could boost sexual performance. It prevents renal dysfunction in patients with type- 2 diabetes.

L-Arginine (Arg) is a proteogenic, semi-essential amino acid: healthy humans can synthesize L-Arginine using L-Glutamine as a building block; however, premature infants are unable to produce Arg and additional supplementation is required for proper growth and development. Arginine plays pivotal roles in biochemical pathways such as the urea cycle and the biosynthesis of nitric oxide. Arginine and Ammonia concentrations are elevated in patients having a mutation in their ARG1 genes. The mutation causes lower arginase activities – a condition that is known as Argininemia. Arginine has also been advertised as a supplement due to its role in the synthesis of nitric oxide, which helps in vasodilation processes.wisepoqder L(+)-Arginine powder
BioVision's L-Arginine Assay Kit provides a quick, specific, and easy method for the measurement of total L-arginine concentrations in a wide variety of samples. In this enzyme-based assay, L-arginine is converted into a series of intermediates, which will further react with a probe producing a stable colorimetric signal (OD: 450 nm). The kit is simple to use, sensitive and high-throughput adaptable and can detect as low as 1 nmol/well of L-arginine in biological samples.

There are plenty of powerful new drugs to help prevent and treat chronic health problems. But we also know that certain nutrients may help, as well. Take arginine, for example. Arginine has gotten lots of attention lately for its potential heart benefits. That's important because, today, about 85.6 million Americans have some form of cardiovascular disease.wisepoqder Antiaging Powder

Deficiencies of arginine are rare. It's abundant in many different types of foods, and your body can also make it. Arginine-rich foods include red meat, fish, poultry, wheat germ, grains, nuts and seeds, and dairy products. But what does arginine do for the heart, and are there potential side effects?As a natural dietary supplement, arginine has garnered particular attention for its possible heart benefits.

What Are Arginine's Heart Benefits?
In the body, the amino acid arginine changes into nitric oxide (NO). Nitric oxide is a powerful neurotransmitter that helps blood vessels relax and also improves circulation.

Some evidence shows that arginine may help improve blood flow in the arteries of the heart. That may improve symptoms of clogged arteries, chest pain or angina, and coronary artery disease. However, there currently is no data on how the long-term use of arginine affects cholesterol or heart health.Since arginine may help arteries relax and improve blood flow, it may also help with erectile dysfunction.

There are other potential health benefits with arginine, such as possible reduction of blood pressure in some people and improved walking distance in patients with intermittent leg cramping and weakness known as intermittent claudication. However, the scientific studies are not conclusive enough for experts to make any firm recommendations.

Not all studies on arginine have been positive. A 2006 study showed that arginine was not helpful -- and may have been harmful -- for treating heart attacks in combination with standard treatment.

Senolytics target cellular senescence, a process in which damaged cells, rather than dying, persist and become toxic to cells around them. Cellular senescence has been shown to drive multiple age-related diseases, including idiopathic pulmonary fibrosis (IPF), a chronic, irreversible and progressive disease that results in scarring of the lungs. In animal studies, run by Mayo Clinic collaborators James Kirkland, M.D., Ph.D.; Nathan LeBrasseur, Ph.D., M.S., and Tamara Tchkonia, Ph.D., senolytics selectively cleared these toxic cells in mice that model IPF.wisepoqder Quercetin

A lethal disease for which there are few options

"IPF is a devastating and progressive fibrotic lung disease with a median survival of less than five years in newly diagnosed adults usually over 60 years of age," said Anoop M. Nambiar, M.D., M.S., associate professor of medicine at UT Health San Antonio and founding director of the university's Interstitial Lung Disease Program, one of 60 Pulmonary Fibrosis Foundation Care Centers in the United States. Dr. Nambiar is co-first author of the research manuscript and enrolled 12 of the patients at UT Health San Antonio and the South Texas Veterans Health Care System.

Despite the current availability of two U.S. Food and Drug Administration-approved therapies that may slow down disease progression in some IPF patients, the prognosis remains poor and is worse than for many common cancers, Dr. Nambiar said. Lung transplantation may be lifesaving, but often is only an option for younger, healthier patients. "There remains a significant unmet need for safer and better treatments for patients with IPF," Dr. Nambiar said.

Patients enrolled in Texas, North Carolina

In this first-in-human pilot study, the investigators enrolled 14 older adults diagnosed with stable, primarily mild-to-moderate IPF. Participants were enrolled at both UT Health San Antonio, which served as the primary patient recruitment site, and Wake Forest medical school, which initiated the trial and served as the study coordinating center. "Though small, this pilot study marks a major breakthrough in how we treat age-related diseases such as IPF," said Jamie Justice, Ph.D., assistant professor at Wake Forest medical school, co-lead investigator and corresponding study author. "Here, we've therapeutically targeted a fundamental biological hallmark of aging that is implicated in IPF, and we show early but promising results for the first time in human patients. This small study represents a major paradigm shift in treatment strategy."

Each participant received two senolytic drugs, dasatinib and quercetin (DQ), taken by mouth for three consecutive days each week for three consecutive weeks (nine doses total). All patients were able to comply with this regimen without any discontinuation of the study drugs.

The research team measured clinical laboratory chemistries before and after DQ administration, and performed rigorous symptom questionnaires weekly of health, quality of life and side effects to obtain preliminary evidence of safety and tolerability. The team also evaluated markers of physical function including six-minute walk distance, walking speed, sitting-to-standing repetitions, a frailty index based on clinical laboratory chemistries, and biological assays of senescence-associated proteins secreted by the toxic cells.