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Product Name: Indapamide
CAS: 26807-65-8
Standard: Corporate Standard
Natural/Synthetic: Synthetic
Source of extraction: for export only
Level: Pharmaceutical grade
Content: 99%
Appearance: white powder
Packing: 25 / cardboard drum can be split
Field: Diuretic antihypertensive drugs
Deferred Products: Indapamide Tablets, Indapamide Capsules, Indapamide Sustained Release Tablets
Use: For the treatment of mild to moderate essential hypertension
Dosage: Adults: conventional oral dose 1. Hypertension: 2.5mg each time, once daily. It can be increased to 5 mg once daily after 4 weeks. The maintenance dose is 2.5mg each time, every other day. 2. Water and sodium retention: Each 2.5mg, once daily. It can be increased to 5 mg once daily after 1 week. Elderly dose: dosage.
High Quality Indapamide 99% CAS: 26807-65-8

Brief Introduction of Active Pharmaceutical Ingredients Indapamide:

1. Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.

2. White needle crystal or crystalline powder, odorless, tasteless. It is almost insoluble in water or dilute hydrochloric acid, while it can be dissolved in ethanol or ethyl acetate, and it is soluble in acetone, acetic acid, slightly soluble in chloroform or ether.

3. Indapamide is currently the most popular non-prescription diuretic antihypertensive drug with good efficacy, stable blood pressure, fewer side effects, etc.

Medical Application of Active Pharmaceutical Ingredients Indapamide:

1. This medication is used to treat high blood pressure. Indapamide is also used to reduce extra salt and fluid in the body (edema) caused by a certain heart problem (congestive heart failure). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Decreasing extra salt and fluid in the body helps to decrease swelling and breathing problems from congestive heart failure and increases your ability to exercise.

2. Indapamide is a "water pill" (diuretic) that increases the amount of urine you make. Getting rid of extra water and salt may help to relax the blood vessels so that bloodcan flow more easily. These effects help to lower blood pressure and decrease the amount of work the heart must do to pump blood.

Function of Active Pharmaceutical Ingredients Indapamide:

1. Indapamide have diuretic and calcium antagonist dual effect by inhibiting the proximal end of the distal convoluted tubule Na+ reabsorption, resulting in diuresis, while by blocking Ca2+ influx especially a higher selectivity for vascular smooth muscle to dilate the small blood vessels of the outer periphery, resulting in antihypertensive effect. But the effect to vascular smooth muscle is stronger than the diuretic effect.

2. It can lower blood pressure with lower dose compared to diuretic effect. Higher dose will display diuretic effect. But there is no disadvantage compared to thiazide diuretics, that it does not cause orthostatic hypotension, flushing and reflex tachycardia, nor blood lipids, glucose metabolism and renal function.
buzai232 Oct 23 '19, 09:34AM
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Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.

Indapamide is currently the most popular non-prescription diuretic antihypertensive drug with good efficacy, stable blood pressure, fewer side effects, etc.
Indapamide Application
Indapamide is used to treat high blood pressure. Indapamide is also used to reduce extra salt and fluid in the body (edema) caused by a certain heart problem (congestive heart failure). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Decreasing extra salt and fluid in the body helps to decrease swelling and breathing problems from congestive heart failure and increases your ability to exercise.

Indapamide have diuretic and calcium antagonist dual effect by inhibiting the proximal end of the distal convoluted tubule Na+ reabsorption, resulting in diuresis, while by blocking Ca2+ influx especially a higher selectivity for vascular smooth muscle to dilate the small blood vessels of the outer periphery, resulting in antihypertensive effect. But the effect to vascular smooth muscle is stronger than the diuretic effect.
buzai232 Oct 23 '19, 09:27AM
One bride uniquely asked her bridesmaids to sport their own wedding gowns to her recent wedding — though she ultimately stole the show in an ice blue frock.

Earlier this week, a photo of actress Audrey Moore and her 10 beaming bridesmaids went viral on Reddit, winning over 90,000 upvotes in four days.“We thought it was sad that most women only get to wear their wedding dress once, so we invited all the women coming to our non-traditional wedding to wear their old wedding dresses again!” Moore’s now-husband, writer Jesse Lumen, wrote on the social media forum platform.www.eisenge.com

Tying the knot on Dec. 30, the California bride told BuzzFeed that they wanted their wedding to authentically capture the playful spirit of their personalities.We really wanted our wedding to really represent ourselves, our sense of humor, our creativity, and also not just celebrate ourselves but marriage in general as a choice," Moore said of the special day.

With that vision in mind, she and her groom mandated a unique dress code, inviting all of the women in attendance to wear bridal gowns and the groomsmen to wear matching tuxedo-style hoodies, while also giving merrymakers the option of arriving in costume as well."I've been to all of their weddings and I saw them all in their beautiful dresses. I wanted them to have the opportunity to wear their really magical, beautiful dress a second time,” she told the outlet.

Though some Reddit users voiced concern that unwed female guests in attendance may have felt left out by the wedding gown dress code request, the bride told BBC that it was all in good fun."I'm the last one to be married in my group of friends. I was pretty much the last girl standing," she said, detailing that some unmarried women "wore their mother's wedding dress or put on a costume."In the days since, Moore and Lumen’s one-of-a-kind wedding day has won major applause on social media.

“I've filmed/edited well over 100 weddings. This is the coolest, most unique one I've ever seen,” one Reddit fan wrote online.“I would totally take this chance to be dressed as Darth Vadar at the wedding if you said I could wear a costume,” another agreed. “Best wedding ever!”
buzai232 Oct 23 '19, 09:20AM
Who doesn’t like surfing on the internet? However you have to realise that surfing is not always anonymously. The Internet Service Providers (ISP) keep the data from everyone that surfs on the internet. They know how to get all kinds of personal information by controlling every step you make on the internet. The ISP’s know what websites you visit, how many hours you are active and from which location. They can then sell this information to third parties. This results in a lot of money for the ISP’s. It is at cost of your privacy. How can you make sure that you can surf anonymously, without that the ISP knows what you are doing? In this article we will give a few tips.

The incognito-mode
Lots of people think that there are fully anonymous on the internet when they use the incognito mode. If it is Google Chrome, Mozilla Firefox or Internet Explorer, every browser has the option to use the internet ‘invisible’. If you use this option the internet history of your browsers isn’t stored. The cookies aren’t stored either. When a different person uses your computer they can’t see what websites you have visited in the browser history. However, this incognito mode doesn’t give you full anonymity when surfing. The websites that are visited in the incognito mode are stored by the internet provider and the visited websites by you. They can always trace these websites back to you. This is done by using the Internet Protocol (IP) address.

The IP-address
The IP-address is some sort of post address of your router. When you visit a website, your IP address is sent and stored. With a IP address, websites can identify and locate you. So they know exactly where you live. With simple tools has the police for example traced many people thanks to the IP address. The incognito mode makes sure that other users from your computer can’t look into your browser history. However, it is not a solution for completely anonymous internet usage.


VPN-Connection vs. ISP
The only way to guarantee anonymity on the internet is by using a RitaVPN connection. With a VPN connection, your computer will make contact with a different, extern server. After that your internet traffic will go through this extern server. The rest of the worldwide web will think that you are using the internet from a different server. At this way, your IP address will remain out of sight. VPN download
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buzai232 Oct 23 '19, 09:14AM
The society in the whole world can’t live without social media. Providers, like Facebook, Facetime, LinkedIn, Instagram and Twitter are the biggest providers from social media platforms. These providers want their users to use the services safely from all over the world. Besides that, companies can’t live without social media for the communication and advertisement with their clients. Social media accounts can offer the user acces at a easy and targeted way for a broader audience. However, the social media life is not always sunshine and rainbows!

Hackers
Because of the fact that internet is more important in our society, and that the number of user from the internet are rising, the hacker activities are also increasing. For the hackers it is more interestring to create chaoas on the internet on purpose. Surprisingly it is not only the indivudals that suffer from this, but also the companies. Once cause for this is the bad security from internet user because of a bad password. Hackers have a easy time in logging it with these hacked passwords. There have been various leaks with Facebook, Flash, Paypal, Uber and WordPress

Dangers of the hacking of private data
On the internet, a lot is discussed and shared. Also the sharing of information is a important aspect with the users of different internet services. Lots of secrets can be shared by third parties. This was visible with The Fappening 2.0 when private videos e.g. Emma Watson, Amanda Seyfried and Laura Ponticorvo were spread through the internet. The Dutch Laura Ponticorvo was the first victim. In 2014 lots of mail accounts from famous stars were hacked and there photos were placed on the internet. To avoid hacking in the Netherlands, a VPN connection can be a solution.

Steal login data for identity theft
Identity fraud happens more often. A few thousand times a year a identity fraud is made. The government advised to the people to handle their private data and images with the greatest care. Too many times it happens that civilians are targeted by a identity fraud. The fraud is used for multiple purchases, taking out loans and spreading personal and privacy sensitive information. Safe internet is the first step in the fight against identity fraud.


Safe internet
The biggest concern from every internetuser is to get informed well on ways to use the internet in a safe way.The first rule to use the internet safely is the use of passwords. It is recommended to have a different password for every log in opportunity. This prevents unsafe situations on the internet. Without the right passwords, logging in on your accounts from Facebook, Facetime, Instagram, Pinterest and Twitter is impossible. A VPN connection can contribute to a safe online enviroment.

VPN connection
The solution to contribute to a more safe internettraffing is to use a VPN connection. A VPN is a Virtual Private Network that knows lots of applications. No only the IP address is hidden, it also gives you the opportunity to watch movies, series and streams safely from abroad. Also, the hackers cant trace inlogdata when there are internet activities made with a safe internet connection.VPN download
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buzai232 Oct 23 '19, 09:08AM
How many times do you hear about it. Privacy sensitive information – sent by mobile phones – that is accessible to anyone on the street. Sometimes with nasty consequences and a rising discussing about online safety as a result. Sometimes you just have these calls that no-one is allowed to hear. Calls that aren’t coming from the anonymity. Besides a normal conversation, under four eyes with the addressed person, a VPN is the best option to send messages safely through the internet. A VPN service in combination with locking your messages should lead to full security. This locking of the messages is also called encryption.

Anonimity
Is your message encrypted, no one can then read your message. Your message is in anonymity. Interception of your message is possible, but opening your message is something totally different and so the content of the message can’t be found. The person who intercepted your message doesn’t have the key and can’t decipher your message. A key? Look at it als a password that can decipher the message. A message without a key or password is worth nothing. Because: not able to open, so not able to read. So very safe. Despite the fact that you can’t open the messages, you can trace the origin of the message, and also to who it is sent. This information can also be hidden by using a VPN service. Nothing to read and nothing to trace, there is not a safer way.

WhatsApp Encryption
Despite the fact that a lot of people don’t know what encrypting files really is, we work with it on a daily basis. Because almost everybody uses WhatsApp. This message service uses end-to-end encryption. All the messages are encrypted, without the need for the sender to do anything with it. When you sent a message with WhatsApp, the app will encrypt the message. The message then goes through the internet to the addressed person. The phone of the receiver has the key (or the password) automatically to open and read the sent messages. Both the sender as the receiver don’t have to do anything, it just happens. No matter the sensitivity of the information, no matter the importance of privacy: It is safe to send sensitive information through WhatsApp.


Dropbox
Still not fully sure about it? Almost anyone knows the cloud service Dropbox. In there, files – like for example photo’s – are stored. Dropbox encrypts just like WhatsApp the standard files you store. So even if curious hackers hack into this service, they can’t open and read the files you places in Dropbox.. Even the hackers miss the key to look at them. Incidentally, the encryption of services like WhatsApp are under pressure, mainly due to the fight against terrorism. For the AIVD, the encryption is a disaster. Messages from and to potential terrorist attacks can be intercepted but he content can’t be seen.VPN download
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buzai232 Oct 23 '19, 09:02AM
Do you think you are safe online? In spite of your safety measures, hackers are capable of doing anything nowadays. The using of Spyware gives the hackers enough information to describe a person, even though they never met him. Sure, the safety technology may evolve, the hackers and their software will do the same. Curious in how you can tackle this? Let’s spy on them!

What is spyware and what does it do?
It’s some sort of malware that is installed on your computer without you knowing. Usually it is hidden and it collect information about your internet activity, the keylogging, passwords and other valuable data for incompetent persons. Spyware can also influence the computer action negatively, can steal password and other valuable data. Spyware can also install extra software, search your web browser or change the computer settings. Briefly, it compromises your safety and anonymity. Spyware can also be used as a type of adware, with which software will give unnecessary pop up ads. It is known that the makers of this software sometimes pay shareware developers to pair their spyware. This pairing happens with the legitimate software to install this at the unaware user.

We aren’t as well protected as you think
Anti-virus software and firewalls are targeted to secure your data on your computer. When you are connected with the internet, this software will do nothing to secure your data. If there is information to be found, it will sent this to a different computer. You can share information through a local private network, or Wifi or through your own internet provider. When you are connected to one of the connections, there can be a few try’s to collect and watch your data. To tackle this problem you have to make connection with a VPN service. A VPN service will make sure that your information can’t be traced or encrypted.

How does a VPN service protect against malware and virus?
VPN works in a very different way than antivirusforware of a firewall. Instead op collection viruses and malware on your device, it encrypts all your data and secures your data when they reach or leave your computer. When a user has access to a VPN network or when he opens a browser with VPN software the connection is fully secured. It doesn’t matter where you are or what type of device you are using. The full connection is secured. As a result, data exchange is secured and you can work safely and anonymously.

The protecting of your data
It doesn’t only stops the treat from viruses and malware that could potentially damage your hardware, it also stops the possibility for stealing your data which can lead to financial loss or even identity theft. A VPN or IP address is a software package that is the best on every single computer, telephone or tablet to build a safe and reliable connection between two contact points on the internet.
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buzai232 Oct 23 '19, 08:52AM
The Internet: it is something without which we cannot live anymore, both as individual users and within companies. The Internet has made the world that we know smaller and yet, simultaneously, larger, exactly because of the innumerable possibilities it offers (on the private and on the business field).

This great expansion of the Internet provides, naturally, also for the existence of many more risks that come with it. Security and protection are often in short supply on the Internet and many people (or at least their surfing behavior) are tracked without their knowledge. At the same time, many people are aware of this and are looking for ways to once again ensure their online security and anonymity.

A VPN connection, or virtual private network, is the perfect solution for this: where a connection with the “regular” Internet can never fully guarantee the security of surfing data and personal information, this is very well the case with a VPN. With such a connection, there is always a mention of a so-called “tunnel” through which all online data is guided. The result? An Internet connection that is impossible to trace and which thus offers much more freedom for users.

Attain anonymity with a VPN
More and more people choose to set up a VPN connection instead of a simple Internet connection and this happens because such a connection makes you anonymous – so to speak – as an Internet user.

Nowadays, it is not difficult at all anymore to surf anonymously, surely due to the great offer of VPN services. Each Internet user possesses a certain IP address that gives information about the geographic location of this user. In this way, it can be determined which content (such as websites and online programs) can or cannot be viewed. For example, someone from the Netherlands may not be able to visit a Russian website because his or her IP address makes it impossible to do so.

A VPN connection, however, circumvents these geographic restrictions by giving the user a new IP address from a country of his choice. Services make it in this way possible to visit American online programs and websites, even if the user is located in the Netherlands. The result? Online anonymity and thus more freedom.


The importance of a no-log policy
There is of course always the risk with such a connection that third parties (such as the government or other official entities) retrieve information about which websites and programs you have visited or donwloaded as an Internet user. Even if your actual Internet behavior remains hidden, it is not impossible to know exactly where you are and what you do.

Many VPN services have, however, a solution for this: a no-log policy. This policy actually entails a simple guideline: all surfing data and history of Internet users (who are connected via the VPN server) are immediately removed so that nobody can learn what exactly this person has been doing. If a government authority requests data from the VPN provider about the browsing history of a given user, they will thus come back empty-handed: the provider itself does not possess this information to begin with.

The result of course is that you as a user of a VPN connection can always be sure of optimal online security and that third parties can never fine you for websites or programs that you have used in the past.


Why is a no-log policy so essential?
Online security is currently in short supply, that much is clear. VPN service offer Internet users the possibility to still enjoy privacy and protection against third parties by routing all Internet traffic via a closed virtual tunnel. In this way, browsing does not only become safer but also much more pleasant.

The no-log policy helps with this because all data about the Internet behavior of a user are removed. Whereas this information normally remains always available (and the risk of fines is thus also much higher), this policy ensures that you as a user of a VPN connection will never have to worry.
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buzai232 Oct 23 '19, 08:47AM
In the modern jewelry world, industrial metals such as tungsten, titanium and stainless steel are in vogue, especially used in men’s jewelry, wedding bands and costume jewelry. Here are the benefits of tungsten:custom Tungsten Rings
Tungsten Affordability

Tungsten is a very affordable metal, and unlike the precious metals, is easy on your wallet. There are different grades of tungsten carbide used in jewelry which can impact the price. For example, high quality tungsten with carbon and nickel included can cost more than other lower grade tungsten carbide combinations.

Compare this white gold comfort fit wedding band with this comfort fit tungsten wedding band. The two rings are very similar looking but the difference in price is considerable!
Some people find that tungsten’s lack of monetary worth makes it cheap and therefore not a good choice for wedding bands. This comes down to personal preference and values.
Tungsten Durability

In the department of durability, tungsten carbide beats all other metals. This is how tungsten compares to other metals:

Gold (3 Mohs)
Platinum (4.5 Mohs)
Palladium (4.5 Mohs)
Rhodium (6 Mohs)
Titanium (6 Mohs)
Tungsten (9)
In fact, it is the hardest metal used in jewelry and the most scratch-resistant. As an object can only be scratched by another object that is harder than it, tungsten cannot be scratched by most materials. Some substances that can cause scratch tungsten are diamonds and moissanites. This means that regardless of the exposure your tungsten ring is subject to, it remains free of scratches.
Tungsten’s Luster

Tungsten rings are highly resistant to tarnishing and corrosion. Over time they do not change color or lose their shine.Because they don’t easily acquire scratches, tungsten remains lustrous and shiny. As a result, this metal has earned itself the nickname ‘forever polished’.
Tungsten is found in several popular colors. Gunmetal gray is a popular color for tungsten and makes for very handsome and unique wedding bands, while white offers a sleek and contemporary choice. White tungsten carbide is very similar in appearance to the popular platinum and white gold metals, giving a modern, stylish look to the wedding band.
You may be considering a black tungsten ring as this offers a striking and nonconventional look, ideal for someone looking to be different. However, black tungsten is made by plating the metal with a coating of black material. While plating tungsten allows for the metal to have different and attractive hues, it also means that over time the plate will flake off and require you to have the piece replated.
buzai232 Oct 23 '19, 08:39AM
The jewelry market has a glittering future as the consumer appetite for jewelry related to the apparel and costume increased tremendously in recent years. In 2020, the jewelry industry is poised to cross $250 billion, which is almost 40 percent increase in sales compared to the last six to seven years.

According to experts, the growth in the sector can also be attributed to changes in the apparel, garments, and clothing industry where new trends have forced designers to continue innovation by offering matching jewelry designs.silver Tungsten Rings men

Factors of Change

In recent years, the pace of development is specifically attributed to the internationalization and consolidation of products, which has made it easier for new trends from around the world to proliferate the sector.

The growth of branded products is yet another reason for the development as brands are able to replicate and produce visionary designs that have attracted consumers who were not brand conscious. The reconfigured channels landscape, where online products have seen double-digit growth, is also boosting sales.

Similarly, hybrid consumption of jewelry has reduced the overall price increasing the buying power of consumers; whereas, fast-changing fashion trends have given impetus to price wars.
Jewelry and gemstone industry is still characterized by the dominance of local players and large national brands. This is evident by Christ in Germany and Chow Tai Fook in China, which are key players in their respective countries. However, these so-called local players are also consolidating their positions in the global market by integrating small local specialized chains. For instance, Tiffany & Co. and Cartier have made tremendous progress by buying shares of local companies or acquiring them outright.

Other well-known international brands such as Zara and H&M are also penetrating worldwide markets to capture sales channels. The pace of internationalization and consolidation will continue to grow in the coming years because this is an effective strategy that has also worked for related apparel and garments industry.

Already smaller players are feeling the heat as major brands are taking over Asian markets because large companies can easily get loans to expand their business, and they can access consumers through online channels. For instance, the share of large well-known Jewelry companies in India rose from a mere 5 percent to almost 35 percent in 2020, according to World Gold Council estimates.

Branded Jewelry

Branded jewelry is quickly becoming one of the most sought-after products in the market. According to McKinsey & Co. analysis, the share of branded jewelry was a mere 10 percent in 2003, which is expected to rise between 335 and 40 percent by 2020.

The newly acquired wealth in Asia has prompted consumers to acquire branded jewelry. Experts believe that a significant portion of consumers in the emerging markets are attracted to the brand because it shows their new wealth deposits. Apart from the “Show-off”, consumers in emerging markets are also interested in the brand because it generates trust and a sense of upgraded lifestyle. On the other hand, branded jewelry in North American and Europe owes its success to many young consumers who seek branded jewelry to enhance their sense of self-expression and self-realization.

In the past, brands such as Pandora and Tiffany & Co. made inroads into the jewelry sector; however, companies local brands such as Hermes and Dior are also taking charge due to the assortment of products and jewelry design. The trend indicates that consumers are also looking for new designs instead of just trusting the global brand.

For local artisans and jewelry makers, the impetus of branded jewelry is a bad omen because local artisans don’t have the muscles to challenge large companies. Still, savvy locals are partnering with companies such as Cadenza and Swarovski’s to showcase their designs. These companies offer curated multi-brand jewelry for their consumers making it a win-win situation for the consumer and the local artisans.

Reconfigured Sales Channels

New sales channels such as the Internet, mono-brand stores, and multi-brand boutique jewelry outlets are thriving in the face of the dynamic landscape. Online sales of jewelry segment will continue to increase in the coming years. The increase will be led by standardized affordable branded jewelry products because customers think that they understand the product without feeling it, which makes it easier to buy such products online.

Despite the emergence of online channels, most customers still prefer to feel the product by walking into a jewelry store because the sale of jewelry is a sensory experience. A lot of consumers also consult online stores and social media before purchasing the item from a brick-and-mortar store.

Monobrands stores such as Pandora have also gained market share as these stores rely on offering streamlined customer experience. Most customers will prefer mono-brand because it gives them a chance to get a more personalized experience and control over their buying patterns. Similarly, small multi-brand stores such as Cadenza and Swarovski’s are also providing a refined touch by concentrating on offering an assortment of unique jewelry from multiple brands.
buzai232 Oct 23 '19, 08:19AM
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