User blogs
The hotly anticipated Yeezy Boost 350 v2 trainers in “Black Static”
launched online and in stores today after months of preparation.
Adidas revealed it would be releasing the £180 trainers on Friday, prompting vast queues outside shops from the early hours of the morning.
Fans queued outside stores nationwide to get their hands on the latest drop from the collaboration between Kanye West’s fashion brand and the sportswear giant. Images and videos on Twitter show crowds of people gathering outside retailers across the UK, France and even Australia.
In Birmingham, demand for the trainers saw long lines of people building from midnight last night while hundreds of shoppers queued for days at Melbourne’s Bourke Street Mall. Some reports suggest the queue along the mall stretched for more than 500m, with several shoppers claiming they had even camped out since Wednesday.
About 100 people have lined up outside Foot Locker in Melbourne’s Bourke St Mall ahead of the new release of Kayne West’s Yeezy sneakers,” one person wrote on Twitter on Thursday.
“A couple at the front of the queue have been camped out for more than 24 hrs.”Meanwhile, sneakerheads who decided to stay at home for the online release were left disappointed after websites including FootLocker and JD Sports crashed, unable to cope with the “heavy traffic”.
One disappointed Twitter user wrote: “FootLockerEU how can you not be prepared for Yeezy drop? Site crashed straight away.”Another person added: “footlocker it's been well over 2 hours and I'm still waitlisted...”buy Yeezy 350 Cheap with best price
Adidas revealed it would be releasing the £180 trainers on Friday, prompting vast queues outside shops from the early hours of the morning.
Fans queued outside stores nationwide to get their hands on the latest drop from the collaboration between Kanye West’s fashion brand and the sportswear giant. Images and videos on Twitter show crowds of people gathering outside retailers across the UK, France and even Australia.
In Birmingham, demand for the trainers saw long lines of people building from midnight last night while hundreds of shoppers queued for days at Melbourne’s Bourke Street Mall. Some reports suggest the queue along the mall stretched for more than 500m, with several shoppers claiming they had even camped out since Wednesday.
About 100 people have lined up outside Foot Locker in Melbourne’s Bourke St Mall ahead of the new release of Kayne West’s Yeezy sneakers,” one person wrote on Twitter on Thursday.
“A couple at the front of the queue have been camped out for more than 24 hrs.”Meanwhile, sneakerheads who decided to stay at home for the online release were left disappointed after websites including FootLocker and JD Sports crashed, unable to cope with the “heavy traffic”.
One disappointed Twitter user wrote: “FootLockerEU how can you not be prepared for Yeezy drop? Site crashed straight away.”Another person added: “footlocker it's been well over 2 hours and I'm still waitlisted...”buy Yeezy 350 Cheap with best price
Intrigue continues to swirl after a recent article in SportsNet brought
up potential questions surrounding Chris Colabello’s Major League
Baseball positive drug test for Dehydrochlormethyltestosterone,
otherwise known as DHCMT or Oral Turinabol. The article quoted
statements by our Chief Science Officer, Don Catlin, M.D., apparently
questioning the test results and also exploring a common point source of
DHCMT. We wished to provide additional clarity as to Dr. Catlin’s views
on the test results and add some thoughts on Colabello, oral turinabol
and the MLB positive drug tests.Turinabol powder supplier
First we wanted to clarify the comments made as to the test results and laboratory data. Dr. Catlin was quoted in the article in the excerpt below:
“The one (DHCMT) case where I looked at the laboratory data, I didn’t think it was very good,” he said in an interview with Sportsnet.
Asked what that meant, Catlin, who has overseen drug testing at multiple Olympics and years ago received a grant from Major League Baseball to help develop a test for HGH, replied: “There’s a long process involved and I just didn’t think the laboratory did a very good job in demonstrating that the (DHCMT) metabolite was present in the urine. But I didn’t want to get into it because of a whole bunch of other issues.”
While that doesn’t necessarily exonerate the players, from a scientific perspective, isn’t that an issue?
“It’s a huge issue, yes.”
Enough of an issue that a player can use it in appeal process?
“Sure.”
And present a reasonable case, and perhaps even win?
“Yes. But that would be a huge concern for baseball and (the testing lab in) Montreal.”,
Because it would call into question the results of other tests and open the door for multiple athletes to contest their doping sanction?
“Right. I did not wish to get into it. But I was interested not so much in the chemistry, but in the source. The three baseball players I talked to were all adamant that they had never used it, didn’t know what it was. And that’s fairly typical, but it also suggests that there’s a source of it somewhere, and my view of it was that it was probably coming from a supplement that they all took.”
Please allow us to distill the intended meaning behind those comments in relation to Colabello, oral turinabol and the MLB positive drug tests. Before we begin, please consider that Dr. Catlin has been reviewing laboratory documentation packages for more than three decades, both those from his own UCLA Olympic Analytical Laboratory, as well as those from other laboratories in the WADA system. He is regarded in the anti-doping arena not only as one of the most renowned scientists but as one of its most frank individuals.
In this situation, Dr. Catlin was taking issue with the way in which the data in the documentation package was presented, not the underlying chemistry involved. This should not come as a surprise to our friend and dedicated colleague Christiane Ayotte, Ph.D., director of the respected Montreal laboratory; it is probably not the first time she has heard Dr. Catlin gripe about her doc packs (Madame Ayotte, malheursement le Don reste inchangé). Gripes aside, it does not mean the results were wrong.
Is it, “Enough of an issue that a player can use it in appeal process?” In Dr. Catlin’s view, if a documentation package is not presented in a clear fashion, it can leave room for athletes or their representatives and experts to attempt to construct a reasonable case to refute the finding. That is what he was alluding to in his response.
As for the chemistry, Dr. Catlin said he did not want to get into it, but wanted to focus instead on the possible source of the issue. As for Colabello, oral turinabol, and the MLB positive drug tests the results ultimately indicated the presence of a long-term metabolite of DHCMT. No parent drug was found and no other metabolite was identified, which is common when relying on the recently identified DHCMT long-term metabolite to detect long-term use of the drug. The finding was considered to be a trace finding for the long-term metabolite of DHCMT.
Before exploring potential sources of DHCMT, we wanted to comment on the DHCMT test itself, and the chemistry involved. Oral turinabol is an old drug that became infamous when it was the primary drug fueling the East German state-sponsored doping from 1968-88. The testing for the drug initially had a short window of detection of a few days. As research expanded on the drug and additional metabolites were identified, the retrospectivity of the testing improved to about 20 days.
In the last several years, a new long-term metabolite, referred to as the M4 metabolite, was identified that increases the window of detection to at least 40-50 days, perhaps longer. The chemistry of DHCMT, however, appears to be such that after 20 days only the long-term metabolite would be detectable, while the parent and other identifying metabolites would no longer be detectable. While not many drugs in the WADA system rely on the presence of a single metabolite to demonstrate the presence of a drug, doing so is certainly acceptable.
When validating such methods, it is commonplace to verify that there are no ‘false positives.’ Whether there could be a genetic anomaly that may produce a ‘false positive’ circumstance that did not present itself during the validation process remains a remote possibility that presents a difficult theory to explore. Many of the athletes in question have been tested before and did not produce positive results. Chasing an inconsistent anomaly could prove to be an endless pursuit. Cody Stanley’s circumstances certainly heighten the intrigue behind the theory, but it has yet to be considered or proven.
Unfortunately, limited research dollars are available to the anti-doping community and labs rightfully use those to validate and demonstrate new testing methods, as they have in the case of DHCMT. However, the community is certainly not afforded the resources to research all the theories on how a ‘false positive’ might occur. As you can imagine, we hear a lot of theories in that regard. If such a possibility does exist, we know our dedicated colleagues in anti-doping like Dr. Ayotte, the experienced folks at Kings College, Cologne, the UCLA Olympic Analytical Laboratory and others will be working diligently to evaluate it and further improve the testing platform for DHCMT.
As for the potential sources of DHCMT, unfortunately it is not hard to find. A quick google search for supplements that contain DHCMT or oral turinabol brings up at least ten different websites where you can buy the drug in pill form. It is clear that oral turinabol remains available, likely through raw material providers in China or elsewhere. Unfortunately, many of these raw material providers also offer legitimate and legal supplement ingredients to the supplement marketplace, leaving open the real possibility for inadvertent contamination of benign products.
First we wanted to clarify the comments made as to the test results and laboratory data. Dr. Catlin was quoted in the article in the excerpt below:
“The one (DHCMT) case where I looked at the laboratory data, I didn’t think it was very good,” he said in an interview with Sportsnet.
Asked what that meant, Catlin, who has overseen drug testing at multiple Olympics and years ago received a grant from Major League Baseball to help develop a test for HGH, replied: “There’s a long process involved and I just didn’t think the laboratory did a very good job in demonstrating that the (DHCMT) metabolite was present in the urine. But I didn’t want to get into it because of a whole bunch of other issues.”
While that doesn’t necessarily exonerate the players, from a scientific perspective, isn’t that an issue?
“It’s a huge issue, yes.”
Enough of an issue that a player can use it in appeal process?
“Sure.”
And present a reasonable case, and perhaps even win?
“Yes. But that would be a huge concern for baseball and (the testing lab in) Montreal.”,
Because it would call into question the results of other tests and open the door for multiple athletes to contest their doping sanction?
“Right. I did not wish to get into it. But I was interested not so much in the chemistry, but in the source. The three baseball players I talked to were all adamant that they had never used it, didn’t know what it was. And that’s fairly typical, but it also suggests that there’s a source of it somewhere, and my view of it was that it was probably coming from a supplement that they all took.”
Please allow us to distill the intended meaning behind those comments in relation to Colabello, oral turinabol and the MLB positive drug tests. Before we begin, please consider that Dr. Catlin has been reviewing laboratory documentation packages for more than three decades, both those from his own UCLA Olympic Analytical Laboratory, as well as those from other laboratories in the WADA system. He is regarded in the anti-doping arena not only as one of the most renowned scientists but as one of its most frank individuals.
In this situation, Dr. Catlin was taking issue with the way in which the data in the documentation package was presented, not the underlying chemistry involved. This should not come as a surprise to our friend and dedicated colleague Christiane Ayotte, Ph.D., director of the respected Montreal laboratory; it is probably not the first time she has heard Dr. Catlin gripe about her doc packs (Madame Ayotte, malheursement le Don reste inchangé). Gripes aside, it does not mean the results were wrong.
Is it, “Enough of an issue that a player can use it in appeal process?” In Dr. Catlin’s view, if a documentation package is not presented in a clear fashion, it can leave room for athletes or their representatives and experts to attempt to construct a reasonable case to refute the finding. That is what he was alluding to in his response.
As for the chemistry, Dr. Catlin said he did not want to get into it, but wanted to focus instead on the possible source of the issue. As for Colabello, oral turinabol, and the MLB positive drug tests the results ultimately indicated the presence of a long-term metabolite of DHCMT. No parent drug was found and no other metabolite was identified, which is common when relying on the recently identified DHCMT long-term metabolite to detect long-term use of the drug. The finding was considered to be a trace finding for the long-term metabolite of DHCMT.
Before exploring potential sources of DHCMT, we wanted to comment on the DHCMT test itself, and the chemistry involved. Oral turinabol is an old drug that became infamous when it was the primary drug fueling the East German state-sponsored doping from 1968-88. The testing for the drug initially had a short window of detection of a few days. As research expanded on the drug and additional metabolites were identified, the retrospectivity of the testing improved to about 20 days.
In the last several years, a new long-term metabolite, referred to as the M4 metabolite, was identified that increases the window of detection to at least 40-50 days, perhaps longer. The chemistry of DHCMT, however, appears to be such that after 20 days only the long-term metabolite would be detectable, while the parent and other identifying metabolites would no longer be detectable. While not many drugs in the WADA system rely on the presence of a single metabolite to demonstrate the presence of a drug, doing so is certainly acceptable.
When validating such methods, it is commonplace to verify that there are no ‘false positives.’ Whether there could be a genetic anomaly that may produce a ‘false positive’ circumstance that did not present itself during the validation process remains a remote possibility that presents a difficult theory to explore. Many of the athletes in question have been tested before and did not produce positive results. Chasing an inconsistent anomaly could prove to be an endless pursuit. Cody Stanley’s circumstances certainly heighten the intrigue behind the theory, but it has yet to be considered or proven.
Unfortunately, limited research dollars are available to the anti-doping community and labs rightfully use those to validate and demonstrate new testing methods, as they have in the case of DHCMT. However, the community is certainly not afforded the resources to research all the theories on how a ‘false positive’ might occur. As you can imagine, we hear a lot of theories in that regard. If such a possibility does exist, we know our dedicated colleagues in anti-doping like Dr. Ayotte, the experienced folks at Kings College, Cologne, the UCLA Olympic Analytical Laboratory and others will be working diligently to evaluate it and further improve the testing platform for DHCMT.
As for the potential sources of DHCMT, unfortunately it is not hard to find. A quick google search for supplements that contain DHCMT or oral turinabol brings up at least ten different websites where you can buy the drug in pill form. It is clear that oral turinabol remains available, likely through raw material providers in China or elsewhere. Unfortunately, many of these raw material providers also offer legitimate and legal supplement ingredients to the supplement marketplace, leaving open the real possibility for inadvertent contamination of benign products.
In simple terms, Methasterone, also known as methyldrostanolone, mostly
sold under the brand name Superdrol, is one of the strongest oral
synthetic and orally-active anabolic-androgenic steroid (AAS). This oral
steroid is popular with athletes, bodybuilders, and those looking to
build lean muscle mass. If you’re getting wind of this drug just now,
here’s our detailed Methasterone review that will tell you everything
you need to know about it.Superdrol powder supplier
The history of Methasterone powder dates back to 1956, when it was discovered during a research that was carried out by the reputable drug manufacturing company, Syntex Corporation. The aim of the research was to find a compound with anti-tumor properties that could help battle cancer. It was during their search for an anti-cancer compound that the researchers stumbled upon Methasterone(Superdrol).
While Methasterone(superdrol) didn’t exhibit many anti-tumor properties, it turned out that that the compound possessed other positive properties. In subsequent tests, it was discovered that Methasterone(superderol) possessed the oral bioavailability of methyltestosterone, while being 20 percent as androgenic and 400% as anabolic, yielding an anabolic to androgenic ratio (also referred to as a Q-ratio) of 20.
Although Methasterone(superderol) was discovered back in the 1950s, it was never commercially available to the public as a prescription drug. It remained unheard of until 2005, when a new found interest in the compound disclosed that Methasterone(superderol) was more anabolic than androgenic. This piece of news was exactly what the bodybuilding society needed as it meant that the drug’s bodybuilding qualities far exceeded the amount that it could affect the body’s hormones.
The history of Methasterone powder dates back to 1956, when it was discovered during a research that was carried out by the reputable drug manufacturing company, Syntex Corporation. The aim of the research was to find a compound with anti-tumor properties that could help battle cancer. It was during their search for an anti-cancer compound that the researchers stumbled upon Methasterone(Superdrol).
While Methasterone(superdrol) didn’t exhibit many anti-tumor properties, it turned out that that the compound possessed other positive properties. In subsequent tests, it was discovered that Methasterone(superderol) possessed the oral bioavailability of methyltestosterone, while being 20 percent as androgenic and 400% as anabolic, yielding an anabolic to androgenic ratio (also referred to as a Q-ratio) of 20.
Although Methasterone(superderol) was discovered back in the 1950s, it was never commercially available to the public as a prescription drug. It remained unheard of until 2005, when a new found interest in the compound disclosed that Methasterone(superderol) was more anabolic than androgenic. This piece of news was exactly what the bodybuilding society needed as it meant that the drug’s bodybuilding qualities far exceeded the amount that it could affect the body’s hormones.
Provironused by those who have had a poor reaction to testosterone
treatments. The drug has shown to be beneficial in treating sexual
dysfunction, impotency and low libido. Mesterolone binds to estrogen
receptors, reducing their activity, which not only reduces estrogen
production, but also encourages natural testosterone production in the
body.Proviron half life
Reviews
Proviron is awesome! I recommend it for sure.I’m pleased with results and always incorporate Proviron into my cycles or in between cycles. –Matt
Business details
We use HKEMS,EMS, Fedex, EUB and so on to deliver the goods, the clearance rate is very high and it’s safe, fast.
Our payment option: Western Union, Money Gram, TT, Bitcoin
The Min.order is 50g of each item, but for some highly valued products and be adjusted appropriately.
The packing will not contain any hormone information and be marked with other common chemical names, so that it can go through the custom smoothly.
We also offer the complete reshipping policy for our clients if any order seized.
High quality, reasonable price, first-class service, high successful delivery rate can be offered.
We can delivery quickly at the very day when receive the payment for we have enough goods in stock.
Reviews
Proviron is awesome! I recommend it for sure.I’m pleased with results and always incorporate Proviron into my cycles or in between cycles. –Matt
Business details
We use HKEMS,EMS, Fedex, EUB and so on to deliver the goods, the clearance rate is very high and it’s safe, fast.
Our payment option: Western Union, Money Gram, TT, Bitcoin
The Min.order is 50g of each item, but for some highly valued products and be adjusted appropriately.
The packing will not contain any hormone information and be marked with other common chemical names, so that it can go through the custom smoothly.
We also offer the complete reshipping policy for our clients if any order seized.
High quality, reasonable price, first-class service, high successful delivery rate can be offered.
We can delivery quickly at the very day when receive the payment for we have enough goods in stock.
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1-Test Cyp(Dihydroboldenone), most commonly known as 1-testosterone, is a 5alpha reduced form of the steroid boldenone. This lack of 5alpha reduction with the compound allows users to administe it without suffering the negative side effects associated with Dihydroboldenone Cypionate chemical reaction but also eliminates the benefits as well. In fact 1-Test Cyp is chemically identical to the Methenolone ( Prima 100) except for the 1-methylation that is apart of Methenolone. Also 1-Test Cyp is structurally similar to GP Bold 200 and less so to Testosterone despite the commonly used name for it, 1-Testosterone.1-Test Cyp(Dihydroboldenone) is a potent anabolic.
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1-Test Cyp(Dihydroboldenone), most commonly known as 1-testosterone, is a 5alpha reduced form of the steroid boldenone. This lack of 5alpha reduction with the compound allows users to administe it without suffering the negative side effects associated with Dihydroboldenone Cypionate chemical reaction but also eliminates the benefits as well. In fact 1-Test Cyp is chemically identical to the Methenolone ( Prima 100) except for the 1-methylation that is apart of Methenolone. Also 1-Test Cyp is structurally similar to GP Bold 200 and less so to Testosterone despite the commonly used name for it, 1-Testosterone.1-Test Cyp(Dihydroboldenone) is a potent anabolic.
DHB, also known as Dihydroboldenone/DHB powder supplier
or 1-Testosterone, has gotten a lot of hype in the past few years in
the bodybuilding community.Guys are always looking for the new exotic
steroid to try.It's almost like a form of shiny object syndrome.
Juice heads are looking for the next best thing, and as soon as a hormone they haven't tried starts getting some traction in the community, they jump on the bandwagon assuming that this new hormone must hold the key to unlocking their true bodybuilding potential.
The fact of the matter is that 1-Testosterone has been around for quite some time, however, it just was never seen as efficacious enough to pursue in a therapeutic context.
What Is DHB?
DHB is a synthetic androstane steroid and a derivative of dihydrotestosterone (DHT).It is more commonly known as the 5-alpha reduced metabolite of Boldenone (Equipoise).Just like how Testosterone interacts with 5-alpha reductase to produce dihydrotestosterone (DHT), Boldenone 5-alpha reduces into DHB (Dihydroboldenone).
Among many using this hormone in a performance enhancing context, it is reported to be formidable to Trenbolone in regards to muscle building potential, but with a more favorable side-effect profile.
Advocates of the dihydroboldenone claim that it is twice as strong as Testosterone.This claim is typically based on the premise that DHB features an anabolic to androgenic ratio of 200/100.Thus, it is implied to be twice as tissue selective as Testosterone, milligram for milligram.Unlike its parent hormone, DHB features no estrogenic effects, which is seen as a desirable trait among those seeking efficacious steroids to use in conjunction with Testosterone.
Boldenone (Equipoise) Vs DHB (Dihydroboldenone)
Boldenone (Equipoise) is a derivative of Testosterone that was created by adding a double-bond between carbon atoms one and two.This bond dramatically slows aromatization and makes the steroid a poor substrate for 5-alpha reductase.While Boldenone is a substrate for 5-alpha reductase and can be converted into DHB, the amount converted by even a high dose of Boldenone is not substantial.
Although Boldenone inherently has strong anabolic effects and moderate androgenic effects, DHB is perceived by many in the bodybuilding community as the superior hormone in a muscle building context.Mega-dosing EQ in order to try and achieve moderate serum concentrations of DHB is a strategy that has been deployed by many bodybuilders in the past.
Due to the parent hormone Equipoise being such a poor substrate for 5-alpha reductase, an increasing number of bodybuilders have started to simply opt to use straight DHB instead.
Juice heads are looking for the next best thing, and as soon as a hormone they haven't tried starts getting some traction in the community, they jump on the bandwagon assuming that this new hormone must hold the key to unlocking their true bodybuilding potential.
The fact of the matter is that 1-Testosterone has been around for quite some time, however, it just was never seen as efficacious enough to pursue in a therapeutic context.
What Is DHB?
DHB is a synthetic androstane steroid and a derivative of dihydrotestosterone (DHT).It is more commonly known as the 5-alpha reduced metabolite of Boldenone (Equipoise).Just like how Testosterone interacts with 5-alpha reductase to produce dihydrotestosterone (DHT), Boldenone 5-alpha reduces into DHB (Dihydroboldenone).
Among many using this hormone in a performance enhancing context, it is reported to be formidable to Trenbolone in regards to muscle building potential, but with a more favorable side-effect profile.
Advocates of the dihydroboldenone claim that it is twice as strong as Testosterone.This claim is typically based on the premise that DHB features an anabolic to androgenic ratio of 200/100.Thus, it is implied to be twice as tissue selective as Testosterone, milligram for milligram.Unlike its parent hormone, DHB features no estrogenic effects, which is seen as a desirable trait among those seeking efficacious steroids to use in conjunction with Testosterone.
Boldenone (Equipoise) Vs DHB (Dihydroboldenone)
Boldenone (Equipoise) is a derivative of Testosterone that was created by adding a double-bond between carbon atoms one and two.This bond dramatically slows aromatization and makes the steroid a poor substrate for 5-alpha reductase.While Boldenone is a substrate for 5-alpha reductase and can be converted into DHB, the amount converted by even a high dose of Boldenone is not substantial.
Although Boldenone inherently has strong anabolic effects and moderate androgenic effects, DHB is perceived by many in the bodybuilding community as the superior hormone in a muscle building context.Mega-dosing EQ in order to try and achieve moderate serum concentrations of DHB is a strategy that has been deployed by many bodybuilders in the past.
Due to the parent hormone Equipoise being such a poor substrate for 5-alpha reductase, an increasing number of bodybuilders have started to simply opt to use straight DHB instead.
China Lanreotide Peptide Powder (INN) for Neuroendocrine Tumors
Lanreotide powder (INN) is a medication used in the management of acromegaly and symptoms caused by neuroendocrine tumors, most notably carcinoid syndrome.
Lanreotide is used in the treatment of acromegaly, due to both pituitary and non-pituitary growth hormone-secreting tumors, and the management of symptoms caused by neuroendocrine tumors, particularly carcinoid tumors and VIPomas. In the United States and Canada, lanreotide is only indicated for the treatment of acromegaly. In the United Kingdom, it is also indicated in the treatment of thyrotrophic adenoma,a rare tumor of the pituitary gland which secretes TSH.
Lanreotide also shows activity against non-endocrine tumors, and, along with other somatostatin analogues, is being studied as a possible general antitumor agent.
Synonyms:LANREOTIDE;AUTOGEL;BETA-(2-NAPHTHYL)-D-ALA-CYS-TYR-D-TRP-LYS-VAL-C YS-THR AMIDE;BIM-23014;ANGIOPEPTIN;H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-THR-NH2;H-D -2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-THR-NH2, (DISULFIDE BOND);IPSTYL
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Product Categories:hormones
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Lanreotide Introduction:
Lanreotide (as lanreotide acetate) is manufactured by Ipsen, and marketed under the trade name Somatuline. It is available in several countries, including the United Kingdom, Australia and Canada, and was approved for sale in the United States by the Food and Drug Administration (FDA) on August 30, 2007.
Lanreotide Indications
Lanreotide is used in the treatment of acromegaly, due to both pituitary and non-pituitary growth hormone-secreting tumors, and the management of symptoms caused by neuroendocrine tumors, particularly carcinoid tumors and VIPomas. In the United States and Canada, lanreotide is only indicated for the treatment of acromegaly. In the United Kingdom, it is also indicated in the treatment of thyrotrophic adenoma, a rare tumor of the pituitary gland which secretes.
Lanreotide also shows activity against non-endocrine tumors, and, along with other somatostatin analogues, is being studied as a possible general antitumor agent.
Lanreotide ,In Dec 2014 the US FDA approved lanreotide for the treatment of patients with unresectable, well or moderately differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
Lanreotide powder (INN) is a medication used in the management of acromegaly and symptoms caused by neuroendocrine tumors, most notably carcinoid syndrome.
Lanreotide is used in the treatment of acromegaly, due to both pituitary and non-pituitary growth hormone-secreting tumors, and the management of symptoms caused by neuroendocrine tumors, particularly carcinoid tumors and VIPomas. In the United States and Canada, lanreotide is only indicated for the treatment of acromegaly. In the United Kingdom, it is also indicated in the treatment of thyrotrophic adenoma,a rare tumor of the pituitary gland which secretes TSH.
Lanreotide also shows activity against non-endocrine tumors, and, along with other somatostatin analogues, is being studied as a possible general antitumor agent.
Synonyms:LANREOTIDE;AUTOGEL;BETA-(2-NAPHTHYL)-D-ALA-CYS-TYR-D-TRP-LYS-VAL-C YS-THR AMIDE;BIM-23014;ANGIOPEPTIN;H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-THR-NH2;H-D -2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-THR-NH2, (DISULFIDE BOND);IPSTYL
CAS:108736-35-2
MF:C54H69N11O10S2
MW:1096.32
Product Categories:hormones
storage temp. :20°C
Chemical Properties:White to off-white lyophilised powder
Lanreotide Introduction:
Lanreotide (as lanreotide acetate) is manufactured by Ipsen, and marketed under the trade name Somatuline. It is available in several countries, including the United Kingdom, Australia and Canada, and was approved for sale in the United States by the Food and Drug Administration (FDA) on August 30, 2007.
Lanreotide Indications
Lanreotide is used in the treatment of acromegaly, due to both pituitary and non-pituitary growth hormone-secreting tumors, and the management of symptoms caused by neuroendocrine tumors, particularly carcinoid tumors and VIPomas. In the United States and Canada, lanreotide is only indicated for the treatment of acromegaly. In the United Kingdom, it is also indicated in the treatment of thyrotrophic adenoma, a rare tumor of the pituitary gland which secretes.
Lanreotide also shows activity against non-endocrine tumors, and, along with other somatostatin analogues, is being studied as a possible general antitumor agent.
Lanreotide ,In Dec 2014 the US FDA approved lanreotide for the treatment of patients with unresectable, well or moderately differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
Hot Selling 99.5% Purity and High Standard Ipamorelin Powder
Ipamorelin powder a fascinating new muscle building discovery that is getting a lot of attention in the bodybuilding world. Like the GHRP-6 peptide (releasing hexapeptide), it is a synthetic peptide that has powerful releasing properties. And these releasing properties are what is of interest to athletes and bodybuilders since they can make a tremendous difference in the amount of muscle you can grow and how quickly you burn fat.
Application:
Ipamorelin is an interesting peptide taken 300mcg twice daily or you could lower the dose for 3 times daily, side effects are head rushs, I would recommend taking this 30 minutes before workout ,with gear, Ipamorelin is a new and potent synthetic pentapeptide which has distinct .With the objective of investigating the effects on longitudinal bone growth rate , body weight , , Ipamorelin in different doses (0, 18, 90 and 450 μg/day) was injected three times daily for 15 days to test subjects, After intravital Tetracycline labelling on days 0, 6, and 13, LGR was determined by measuring the distance between the respective fluorescent bands in the proximal tibia metaphysis. Ipamorelin dose-dependently increased LGR from 42 μm/day in the vehicle group to 44, 50, and 52 μm/day in the treatment groups .
Ipamorelin powder a fascinating new muscle building discovery that is getting a lot of attention in the bodybuilding world. Like the GHRP-6 peptide (releasing hexapeptide), it is a synthetic peptide that has powerful releasing properties. And these releasing properties are what is of interest to athletes and bodybuilders since they can make a tremendous difference in the amount of muscle you can grow and how quickly you burn fat.
Application:
Ipamorelin is an interesting peptide taken 300mcg twice daily or you could lower the dose for 3 times daily, side effects are head rushs, I would recommend taking this 30 minutes before workout ,with gear, Ipamorelin is a new and potent synthetic pentapeptide which has distinct .With the objective of investigating the effects on longitudinal bone growth rate , body weight , , Ipamorelin in different doses (0, 18, 90 and 450 μg/day) was injected three times daily for 15 days to test subjects, After intravital Tetracycline labelling on days 0, 6, and 13, LGR was determined by measuring the distance between the respective fluorescent bands in the proximal tibia metaphysis. Ipamorelin dose-dependently increased LGR from 42 μm/day in the vehicle group to 44, 50, and 52 μm/day in the treatment groups .
White Lyophilized Powder n acetyl selank peptide 5mg 10mg 2mg selank
Selank powder, which was developed in Russia, is a short peptide with nootropic and anxiolytic properties. It is a synthetic analogue of naturally occurring Tuftsin, an immunomodulatory peptide that modulates IL-6, T helper cells, monoamine neurotransmitters, and brain-derived neurotropic factor (BDNF). In fact, Selank and Tuftsin are essentially the same except that Selank has an additional four amino acids in its chain that help to improve metabolic stability and half-life.
Selank has been tested in clinical trials as a potential treatment for generalized anxiety disorder.
Selank Anxiety Effects Based on Genes Related to GABA Neurotransmitter
According to Dr. Anastasiya Volkova of the Institute of Molecular Genetics in Russia, “numerous clinical studies have shown that Selank has strong antianxiety and neuroprotective effects in the treatment of anxiety. The clinical effects of Selank are similar to those of the classical antianxiety medications such as benzodiazepine, which are allosteric modulators of GABAA receptors and increase the inhibitory action of GABA.” Selank’s effects include reducing anxiety, improving mood, lower stress levels, and positively influencing memory and learning. Like benzodiazepines, low doses of Selank have a sedating effect. Unlike benzodiazepines, Selank does not appear to be habit-forming and does not lead to symptoms of withdrawal or amnesia.
Research in rats shows that of the 84 genes known to be connected to GABA signaling in some way, seven are heavily modulated by Selank and 45 show some change in expression when the peptide is administered. Overall, 52 genes related to GABA signaling are affected by Selank to some degree. These results indicate that Selank can directly influence the expression of genes in nerve cells and that it likely produces effects by changing the affinity of the GABA receptor for GABA[1].
This alteration of receptor affinity likely explains why Selank is synergistic with benzodiazepines and other GABA receptor agonists.
Selank and the Immune System in Anxiety
Research in patients with depression indicates that Selank can suppress the gene responsible for the production of the inflammatory cytokine IL-6. Interestingly, this effect is only seen in patients with depression and does not appear to take place in healthy individuals[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression.
When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins.
Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops.
Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation[8].This alteration of receptor affinity likely explains why Selank is synergistic with benzodiazepines and other GABA receptor agonists.
Selank and the Immune System in Anxiety
Research in patients with depression indicates that Selank can suppress the gene responsible for the production of the inflammatory cytokine IL-6. Interestingly, this effect is only seen in patients with depression and does not appear to take place in healthy individuals[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression.
When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins.
Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops.
Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation[8].
Selank powder, which was developed in Russia, is a short peptide with nootropic and anxiolytic properties. It is a synthetic analogue of naturally occurring Tuftsin, an immunomodulatory peptide that modulates IL-6, T helper cells, monoamine neurotransmitters, and brain-derived neurotropic factor (BDNF). In fact, Selank and Tuftsin are essentially the same except that Selank has an additional four amino acids in its chain that help to improve metabolic stability and half-life.
Selank has been tested in clinical trials as a potential treatment for generalized anxiety disorder.
Selank Anxiety Effects Based on Genes Related to GABA Neurotransmitter
According to Dr. Anastasiya Volkova of the Institute of Molecular Genetics in Russia, “numerous clinical studies have shown that Selank has strong antianxiety and neuroprotective effects in the treatment of anxiety. The clinical effects of Selank are similar to those of the classical antianxiety medications such as benzodiazepine, which are allosteric modulators of GABAA receptors and increase the inhibitory action of GABA.” Selank’s effects include reducing anxiety, improving mood, lower stress levels, and positively influencing memory and learning. Like benzodiazepines, low doses of Selank have a sedating effect. Unlike benzodiazepines, Selank does not appear to be habit-forming and does not lead to symptoms of withdrawal or amnesia.
Research in rats shows that of the 84 genes known to be connected to GABA signaling in some way, seven are heavily modulated by Selank and 45 show some change in expression when the peptide is administered. Overall, 52 genes related to GABA signaling are affected by Selank to some degree. These results indicate that Selank can directly influence the expression of genes in nerve cells and that it likely produces effects by changing the affinity of the GABA receptor for GABA[1].
This alteration of receptor affinity likely explains why Selank is synergistic with benzodiazepines and other GABA receptor agonists.
Selank and the Immune System in Anxiety
Research in patients with depression indicates that Selank can suppress the gene responsible for the production of the inflammatory cytokine IL-6. Interestingly, this effect is only seen in patients with depression and does not appear to take place in healthy individuals[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression.
When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins.
Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops.
Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation[8].This alteration of receptor affinity likely explains why Selank is synergistic with benzodiazepines and other GABA receptor agonists.
Selank and the Immune System in Anxiety
Research in patients with depression indicates that Selank can suppress the gene responsible for the production of the inflammatory cytokine IL-6. Interestingly, this effect is only seen in patients with depression and does not appear to take place in healthy individuals[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression.
When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins.
Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops.
Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation[8].
Octreotide Market Opportunities, Top Vedors, Industry Survey, Capital Investment and Trend Report By 2024
Octreotide Acetate powder, Octreotide powder Market Report 2019 to 2024” is the definitive study of the global Octreotide market. The content includes orientation technology, industry drivers, geographic trends, market statistics, market forecasts, producers, and equipment suppliers.
The report firstly introduced the Octreotide basics: definitions, classifications, applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on. Then it analyzed the world’s main region market conditions, including the product price, profit, capacity, production, supply, demand and market growth rate and forecast etc. In the end, the report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.
The production of Octreotide mainly focuses on Europe, China and India. The Europe occupies the largest share and it about reach 66.36% in 2015. Novartis exports to other countries mainly in the form of finished drug.
The Octreotide product increased fast in the past five years, the production growth in the past two years. There have been new manufacturers to enter the field year by year. But for now , it is difficult to obtain certification.
It will expect that the production and the capacity will increase fast in the future, But with octreotide acetate in China continues to mature in manufacturing technology, in the future, trade of octreotide API will gradually decrease, more and more Octreotide will sold as finished medicine.
The worldwide market for Octreotide is expected to grow at a CAGR of roughly xx% over the next five years, will reach xx million US$ in 2024, from xx million US$ in 2019, according to a new GIR (Global Info Research) study.
This report focuses on the Octreotide in global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. This report categorizes the market based on manufacturers, regions, type and application.
The overviews, SWOT analysis and strategies of each vendor in the Octreotide market provide understanding about the market forces and how those can be exploited to create future opportunities.
Octreotide Acetate powder, Octreotide powder Market Report 2019 to 2024” is the definitive study of the global Octreotide market. The content includes orientation technology, industry drivers, geographic trends, market statistics, market forecasts, producers, and equipment suppliers.
The report firstly introduced the Octreotide basics: definitions, classifications, applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on. Then it analyzed the world’s main region market conditions, including the product price, profit, capacity, production, supply, demand and market growth rate and forecast etc. In the end, the report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.
The production of Octreotide mainly focuses on Europe, China and India. The Europe occupies the largest share and it about reach 66.36% in 2015. Novartis exports to other countries mainly in the form of finished drug.
The Octreotide product increased fast in the past five years, the production growth in the past two years. There have been new manufacturers to enter the field year by year. But for now , it is difficult to obtain certification.
It will expect that the production and the capacity will increase fast in the future, But with octreotide acetate in China continues to mature in manufacturing technology, in the future, trade of octreotide API will gradually decrease, more and more Octreotide will sold as finished medicine.
The worldwide market for Octreotide is expected to grow at a CAGR of roughly xx% over the next five years, will reach xx million US$ in 2024, from xx million US$ in 2019, according to a new GIR (Global Info Research) study.
This report focuses on the Octreotide in global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. This report categorizes the market based on manufacturers, regions, type and application.
The overviews, SWOT analysis and strategies of each vendor in the Octreotide market provide understanding about the market forces and how those can be exploited to create future opportunities.