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E-cigarettes work by heating a flavored liquid to make a mist that users inhale, or “vape.” These flavored liquids, called e-liquids, usually contain nicotine. But not always. Manufacturers add nicotine for vapers who want a buzz from their e-cigarettes. It’s the same stimulant that true cigarettes deliver. That nicotine — made from tobacco — qualifies most e-cigs as “tobacco products.”
The nicotine may be useful for adults who are addicted to cigarettes and want to wean themselves off. But nicotine can harm children and teens. That’s why some young people may choose to vape instead of smoke, and use nicotine-free products. But the new data suggest that e-cigs can still be toxic, even without nicotine.“We know these flavors are really attractive to teens,” says Irfan Rahman. He works at the University of Rochester in New York. He says studies have shown that one reason many teens try e-cigarettes is an interest in fruity and candy-flavored products.
As a toxicologist, Rahman studies whether various materials can poison the body’s cells or tissues. His team decided to test whether certain flavored e-liquids are toxic (meaning poisonous). They tested several common e-liquid flavorings. These included cinnamon roll, cotton candy, melon, pineapple, coconut and cherry.
Such flavorings are considered safe in foods. That’s because after a person swallows them, they’re broken down in the gut. But that doesn’t mean these same chemicals are safe to breathe in. They could harm parts of the respiratory tract, such as the lungs.
Rahman’s team didn’t expose people to these flavorings, in case they were harmful. Instead, they tested e-liquid chemicals on human cells in a dish. This helped them judge whether the chemicals might also harm cells inside the body.u2022eney7485yyWEEEEDD
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1. Electronic Cigarette contain nicotine, which is addictive and can harm the developing adolescent brain, said Stanton Glantz, a professor of medicine at UC San Francisco.
A lot of the kids who take up vaping are at low risk for smoking, but once they start using e-cigarettes, they are three to four times more likely to start using cigarettes, Glantz said.
“The biggest health concern with e-cigarettes is they are prolonging and expanding the tobacco industry,” he said.
Glantz, director of UCSF’s Center for Tobacco Control Research and Education, said he was initially neutral on e-cigarettes, but now finds them concerning. Among other hazards, e-cigarettes produce ultrafine particles than can trigger inflammatory problems and lead to heart and lung disease.
“The data is just becoming overwhelming,” Glantz said.
2. E-cigarettes expose people to more than “harmless water vapor”; strictly speaking, the vapor produced when users exhale is actually an aerosol that contains a mixture of nicotine, flavorings and other ingredients that can be toxic.
Stanford University pediatrics professor Bonnie Halpern-Felsher has studied young people’s perceptions of e-cigarettes. In September, she launched a free, downloadable youth tobacco prevention toolkit with an e-cigarette module, funded by the UC Tobacco-Related Disease Research Program, or TRDRP, and the California Department of Education.
“Youths are definitely using e-cigarettes because they think they are cool,” Halpern-Felsher said. “Adolescents and young adults don’t know a lot about e-cigarettes. They think it’s just water or water vapor. They don’t understand it’s an aerosol. They don’t understand that e-cigarettes can have nicotine. They don’t understand that flavorants themselves can be harmful.”
3. The flavors can be toxic. More than 7,000 varieties of flavored e-cigarettes are on the market.
Prue Talbot, a UC Riverside professor of cell biology, screened the cytotoxicity (quality of being toxic to cells) of 36 refill fluids and found that some were highly toxic. The most cytotoxic flavor, Cinnamon Ceylon, contained a chemical called cinnamaldehyde, which gives cinnamon its flavor and whose side-effects may include coughing and sore throats.
Talbot has been studying more flavors and is building a database to help determine the most dangerous ones.
“Flavors are something that could be potentially regulated,” Talbot said.
4. Vaping has secondhand and thirdhand effects. Unlike cigarettes, which emit smoke from the lit end, e-cigarettes don’t produce sidestream emissions between puffs, but they still generate secondhand and thirdhand effects when users exhale the mainstream vapor.
In a TRDRP-funded study, Berkeley Lab researcher Hugo Destaillats led a team that found 31 chemicals that include several toxicants at significant levels in e-cigarette vapor. The most toxic chemicals included acrolein, a severe eye and respiratory irritant; and formaldehyde, an irritant and probable carcinogen.
So, while e-cigarettes deliver fewer cancer-causing chemicals than cigarettes, research has yet to reveal how e-cigarettes fully impact heart and lung health and their cancer-causing potential, Glantz said.He estimates that e-cigarettes are about one-third to one-half as dangerous as cigarettes.u2022eney7485yyWEEEEDD
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