User blogs
For universities and colleges recruitment, development, and retention of
our human resources are crucial to the growth and sustainability of our
institutions. While we recognize that human capital is our most
important resource we often overlook the importance of ongoing
professional development for our administrators, faculty and staff,
particularly as institutions are faced with change and complex
challenges. Over the last decade higher education has seen reduced
funding, new budget models, new technologies, the introduction of
performance targets and metrics, and new student demographics.
Professional development is mission critical for higher education
institutions – and investment in professional development can
differentiate and distinguish an institution as a learning organization
for the future. Teacher training for early years or nursery education
The Centre for Higher Education Research and Development (CHERD) has been providing professional development for university and college administrators and managers for over 30 years. Like institutions, we are changing too, with new current curriculum, technologies and delivery modes. This fall we have two fully online credentials targeted to the evolving higher education professional in Canada: one focusing on University and College Administration and one dedicated to Academic Advising.
The group covers research in initial teacher education, continuing professional development and teachers’ careers.The aims of the Teacher Education and Development SIG are:
to bring together all those with a special interest in the full continuum of teacher education – initial teacher education, induction, early professional development continuing professional development, accomplished teaching/advanced certification and leadership preparation/development across school and higher education settings;
to promote UK-wide, comparative and international perspectives on contemporary developments in policy and practice for teacher education and teaching across the life course;
to promote research on and for teacher education, including consideration of the work and identities of teachers and teacher educators;
to explore and theorise the links between knowledge creation and identity across the continuum of student, teacher and teacher educator learning.
The Centre for Higher Education Research and Development (CHERD) has been providing professional development for university and college administrators and managers for over 30 years. Like institutions, we are changing too, with new current curriculum, technologies and delivery modes. This fall we have two fully online credentials targeted to the evolving higher education professional in Canada: one focusing on University and College Administration and one dedicated to Academic Advising.
The group covers research in initial teacher education, continuing professional development and teachers’ careers.The aims of the Teacher Education and Development SIG are:
to bring together all those with a special interest in the full continuum of teacher education – initial teacher education, induction, early professional development continuing professional development, accomplished teaching/advanced certification and leadership preparation/development across school and higher education settings;
to promote UK-wide, comparative and international perspectives on contemporary developments in policy and practice for teacher education and teaching across the life course;
to promote research on and for teacher education, including consideration of the work and identities of teachers and teacher educators;
to explore and theorise the links between knowledge creation and identity across the continuum of student, teacher and teacher educator learning.
It's time for some summer fun, enrolling in multiple summer camps can be
costly. The good news is there's plenty of free fun to be had that
entertains and even educates children while giving parents' wallets a
vacation too.Weekend activity programmes for children
Find free summer programs for kids that won't cost you a cent and will keep your children busy until the school bell rings again.
Movies
Watch a free movie at the theater or under the stars. Many movie theaters host free movie days throughout the summer. Outdoor movies are usually in the park where there's plenty of room for families to spread out with blankets and coolers.Indoors or outdoors, some free movie events are sponsored, which usually includes games, prizes, and food giveaways. Kids probably won't get to see the latest box office smash, but they do get to watch a family-friendly movie at no cost to you.
Sports Clinics
Learn from college athletes, their coaches, and even professionals in the sport. Free sports clinics are usually held on college campuses for a limited amount of kids. Each free sports clinic has its own rules but many allow children as young as 4 and up to 17 years of age.
Behind-the-Scenes Tours
What's it like to work at a TV station? How does the mail get from point A to point B? Let the kids take a behind the scenes tour to find out.You can tour many places simply by asking. Be creative when choosing locations to visit. If your kids are interested in animals, tour a veterinary hospital. If they like baseball, set up a tour at your local stadium.
Camps
Grants and sponsors make some summer camps free for kids. Art, writing, theater, math, science and reading camps are some of the themes of these camps. But many also include crafts, field trips, and swimming.There are even special free summer camps that cover anti-bullying, conflict resolution, self-esteem, leadership skills, and personal safety topics.
Vacation Bible School
Churches hold Vacation Bible School as an outreach of their ministries. Members of the church, as well as non-members, are invited for a free week of fun. Kids sing songs, learn Bible lessons, make friends, create crafts, perform in skits and learn how to treat others, among other valuable lessons.Each church has its own age guidelines but 3 and up usually benefit the most from Vacation Bible School.
Volunteer Opportunities
As soon as kids can walk, they can start learning the benefits of volunteering with you. When they get older, they can branch out into their own volunteering opportunities.
Cleaning up the park or the beach, collecting books and toys for the less privileged, visiting nursing homes and helping prepare meals for the homeless are just a few of the many ways kids can volunteer.
Library Events
The library is an excellent venue for story time. But did you know there are even more activities for kids at the library that won't get them shushed? Most libraries offer free summer reading programs. Kids sign up to read a certain amount of books over the summer. The library then awards prizes and holds a party for the eager readers at the end of the reading program.
Or just stop in for one of the library's other special events. Themed activity days may include book readings, related crafts, and hands-on learning. For example, a fire safety day might feature stories about firefighters, a dress-up time where kids can put on a firefighter's gear and a visit from a real fire truck so kids can see how it works. Other lessons can also be educational with activities designed to teach kids about computers, stranger danger, and bike and water safety.
Arts and Crafts at Museums
Introduce art appreciation at a young age. Museums are reaching out to future artists through free kids' programs that encourage them to create their own works of art.
Storytime ties book illustrations into the art you find in the museum. Kids enjoy craft time, paint, use clay and a variety of other mediums to enrich their art experience.
Parks and Recreation Activities
Playing in the park can be more than an hour on the playground. Many parks and recreation departments set up a summer schedule of day-long activities.Kids are exposed to the arts, fitness lessons, a variety of sports, even computer instruction. Check your city's local parks and recreation department website to see what activities are planned near you.
Building Workshops
Some home improvement stores offer free building workshops that help kids build everything from a birdhouse to a miniature schoolhouse. Kids get free aprons, goggles and the required tools and supplies to build their own project with the help of the store's employees.The most popular kids' workshops are through Home Depot and Lowe's. Home Depot's Kids Workshop is the first Saturday of the month. Lowe's Build and Grow Clinics are every Saturday.
Admission to Children's Museums, Theaters and Art Museums
Spend a day at a children's learning museum, children's theater or art museum absolutely free. Target Free Days lists thousands of places across the country where admission is free. Some locations have a reduced-cost admission, but most waive the admission fee completely. The program is available all year long, but it's perfect for summer outings with the whole family.
Find free summer programs for kids that won't cost you a cent and will keep your children busy until the school bell rings again.
Movies
Watch a free movie at the theater or under the stars. Many movie theaters host free movie days throughout the summer. Outdoor movies are usually in the park where there's plenty of room for families to spread out with blankets and coolers.Indoors or outdoors, some free movie events are sponsored, which usually includes games, prizes, and food giveaways. Kids probably won't get to see the latest box office smash, but they do get to watch a family-friendly movie at no cost to you.
Sports Clinics
Learn from college athletes, their coaches, and even professionals in the sport. Free sports clinics are usually held on college campuses for a limited amount of kids. Each free sports clinic has its own rules but many allow children as young as 4 and up to 17 years of age.
Behind-the-Scenes Tours
What's it like to work at a TV station? How does the mail get from point A to point B? Let the kids take a behind the scenes tour to find out.You can tour many places simply by asking. Be creative when choosing locations to visit. If your kids are interested in animals, tour a veterinary hospital. If they like baseball, set up a tour at your local stadium.
Camps
Grants and sponsors make some summer camps free for kids. Art, writing, theater, math, science and reading camps are some of the themes of these camps. But many also include crafts, field trips, and swimming.There are even special free summer camps that cover anti-bullying, conflict resolution, self-esteem, leadership skills, and personal safety topics.
Vacation Bible School
Churches hold Vacation Bible School as an outreach of their ministries. Members of the church, as well as non-members, are invited for a free week of fun. Kids sing songs, learn Bible lessons, make friends, create crafts, perform in skits and learn how to treat others, among other valuable lessons.Each church has its own age guidelines but 3 and up usually benefit the most from Vacation Bible School.
Volunteer Opportunities
As soon as kids can walk, they can start learning the benefits of volunteering with you. When they get older, they can branch out into their own volunteering opportunities.
Cleaning up the park or the beach, collecting books and toys for the less privileged, visiting nursing homes and helping prepare meals for the homeless are just a few of the many ways kids can volunteer.
Library Events
The library is an excellent venue for story time. But did you know there are even more activities for kids at the library that won't get them shushed? Most libraries offer free summer reading programs. Kids sign up to read a certain amount of books over the summer. The library then awards prizes and holds a party for the eager readers at the end of the reading program.
Or just stop in for one of the library's other special events. Themed activity days may include book readings, related crafts, and hands-on learning. For example, a fire safety day might feature stories about firefighters, a dress-up time where kids can put on a firefighter's gear and a visit from a real fire truck so kids can see how it works. Other lessons can also be educational with activities designed to teach kids about computers, stranger danger, and bike and water safety.
Arts and Crafts at Museums
Introduce art appreciation at a young age. Museums are reaching out to future artists through free kids' programs that encourage them to create their own works of art.
Storytime ties book illustrations into the art you find in the museum. Kids enjoy craft time, paint, use clay and a variety of other mediums to enrich their art experience.
Parks and Recreation Activities
Playing in the park can be more than an hour on the playground. Many parks and recreation departments set up a summer schedule of day-long activities.Kids are exposed to the arts, fitness lessons, a variety of sports, even computer instruction. Check your city's local parks and recreation department website to see what activities are planned near you.
Building Workshops
Some home improvement stores offer free building workshops that help kids build everything from a birdhouse to a miniature schoolhouse. Kids get free aprons, goggles and the required tools and supplies to build their own project with the help of the store's employees.The most popular kids' workshops are through Home Depot and Lowe's. Home Depot's Kids Workshop is the first Saturday of the month. Lowe's Build and Grow Clinics are every Saturday.
Admission to Children's Museums, Theaters and Art Museums
Spend a day at a children's learning museum, children's theater or art museum absolutely free. Target Free Days lists thousands of places across the country where admission is free. Some locations have a reduced-cost admission, but most waive the admission fee completely. The program is available all year long, but it's perfect for summer outings with the whole family.
Mohsine el Baghdadi always wanted to be an English teacher in China, considering such a job to be ideal.
A friend who taught English in China told the 27-year-old Moroccan that foreign teachers are in high demand, there are boundless opportunities and the jobs are well paid.
Baghdadi’s own experience confirmed this. Replies flooded in after he posted a message on Facebook, stating: “Hello from Morocco. I am an English-language teacher searching for a good job with a good salary in China.”teaching jobs in China for foreigners
Many of the replies were job invitations from recruitment agencies, while others came from language institutes. For the most part, they told Baghdadi that applying for a job in China was straightforward. It was sufficient merely to submit a resume.
The salary also was tempting. Baghdadi teaches English in Morocco, where he is paid $500 a month. However, those who approached him from China offered a monthly salary ranging from $1,500 to $2,500, with a bonus.
But he said some of those who replied appeared too eager to hire foreign teachers, and Baghdadi said he was even given “illegal advice” about getting a job.
The regulation on foreign experts’ work permits states that overseas language teachers in China must obtain a work visa and be a native speaker with a bachelor’s degree or higher, have at least two years of related teaching experience and no criminal record.
This means that Baghdadi, who is not a native English speaker and does not have sufficient experience in teaching the language, may never have the chance to work in China as a teacher.
“But some agencies told me that they could help me apply for a Chinese business visa, and I could become a teacher in China, come what may,” he said.
Teaching English is a lucrative business in China, as the country’s opening-up to the world means more people are looking to learn the “universal language”. For foreigners, their nationality and even their skin tone can, at times, be their ticket to securing a teaching job.
According to a report last year from the Chinese Academy of Social Sciences, 300 million people in China were learning English. There were 50,000 English-language training institutions in the country and the training market was worth as much as 500 billion yuan ($72 billion), the report said.
The high demand for English-language instruction had made finding a job for most foreigners, particularly those who are white, little more than a formality.
According to a survey by Banyuetan, a Xinhua News Agency magazine, in 2017, there were more than 400,000 foreign teachers working in the education sector in China, but only one-third of them were employed legally.
In recent years, the country has been rocked by a number of high-profile scandals resulting from a lack of vigilance in hiring foreign teachers. In some cases, people with questionable backgrounds have landed jobs.
The latest such case occurred last month. On July 23, an English-language teacher from Colombia working at the Hong Huang Lan Kindergarten in Qingdao, Shandong province, was arrested for allegedly molesting a 4-year-old girl.
Earlier in July, 16 foreigners were detained in Xuzhou, Jiangsu province, for allegedly taking drugs. According to Xuzhou police, seven of them work for an education company, and the remaining nine are students.
Media reports later said a number of foreign teachers from the EF Education center in Xuzhou had been detained by police for allegedly taking drugs. According to the company’s website, EF is an international education company based in Sweden, and has centers in many Chinese cities.
In April 2013, media reports said that Neil Robinson, from the United Kingdom, had taught at the Beijing World Youth Academy, an international school, for nearly four years while being wanted for questioning by British police in connection with child sex offences.
Such cases have aroused widespread concern among parents and students, with many of them calling for the qualifications of foreign teachers at English-learning organizations to be subject to nationwide inspection.
On some online expatriate forums, topics such as “How to become an English teacher in China without a work permit”, or “nonnative speakers can also teach in China” are popular. They offer tips for those who want to work in the country without the required documentation or experience.
One of the items stated, “Although a Chinese work visa is the only visa that it is technically legal to teach with, there is also the possibility that they might offer you an alternative one instead, such as a student visa or a business visa.
A friend who taught English in China told the 27-year-old Moroccan that foreign teachers are in high demand, there are boundless opportunities and the jobs are well paid.
Baghdadi’s own experience confirmed this. Replies flooded in after he posted a message on Facebook, stating: “Hello from Morocco. I am an English-language teacher searching for a good job with a good salary in China.”teaching jobs in China for foreigners
Many of the replies were job invitations from recruitment agencies, while others came from language institutes. For the most part, they told Baghdadi that applying for a job in China was straightforward. It was sufficient merely to submit a resume.
The salary also was tempting. Baghdadi teaches English in Morocco, where he is paid $500 a month. However, those who approached him from China offered a monthly salary ranging from $1,500 to $2,500, with a bonus.
But he said some of those who replied appeared too eager to hire foreign teachers, and Baghdadi said he was even given “illegal advice” about getting a job.
The regulation on foreign experts’ work permits states that overseas language teachers in China must obtain a work visa and be a native speaker with a bachelor’s degree or higher, have at least two years of related teaching experience and no criminal record.
This means that Baghdadi, who is not a native English speaker and does not have sufficient experience in teaching the language, may never have the chance to work in China as a teacher.
“But some agencies told me that they could help me apply for a Chinese business visa, and I could become a teacher in China, come what may,” he said.
Teaching English is a lucrative business in China, as the country’s opening-up to the world means more people are looking to learn the “universal language”. For foreigners, their nationality and even their skin tone can, at times, be their ticket to securing a teaching job.
According to a report last year from the Chinese Academy of Social Sciences, 300 million people in China were learning English. There were 50,000 English-language training institutions in the country and the training market was worth as much as 500 billion yuan ($72 billion), the report said.
The high demand for English-language instruction had made finding a job for most foreigners, particularly those who are white, little more than a formality.
According to a survey by Banyuetan, a Xinhua News Agency magazine, in 2017, there were more than 400,000 foreign teachers working in the education sector in China, but only one-third of them were employed legally.
In recent years, the country has been rocked by a number of high-profile scandals resulting from a lack of vigilance in hiring foreign teachers. In some cases, people with questionable backgrounds have landed jobs.
The latest such case occurred last month. On July 23, an English-language teacher from Colombia working at the Hong Huang Lan Kindergarten in Qingdao, Shandong province, was arrested for allegedly molesting a 4-year-old girl.
Earlier in July, 16 foreigners were detained in Xuzhou, Jiangsu province, for allegedly taking drugs. According to Xuzhou police, seven of them work for an education company, and the remaining nine are students.
Media reports later said a number of foreign teachers from the EF Education center in Xuzhou had been detained by police for allegedly taking drugs. According to the company’s website, EF is an international education company based in Sweden, and has centers in many Chinese cities.
In April 2013, media reports said that Neil Robinson, from the United Kingdom, had taught at the Beijing World Youth Academy, an international school, for nearly four years while being wanted for questioning by British police in connection with child sex offences.
Such cases have aroused widespread concern among parents and students, with many of them calling for the qualifications of foreign teachers at English-learning organizations to be subject to nationwide inspection.
On some online expatriate forums, topics such as “How to become an English teacher in China without a work permit”, or “nonnative speakers can also teach in China” are popular. They offer tips for those who want to work in the country without the required documentation or experience.
One of the items stated, “Although a Chinese work visa is the only visa that it is technically legal to teach with, there is also the possibility that they might offer you an alternative one instead, such as a student visa or a business visa.
Six police officers who speak English, Japanese and Korean are at the
service of foreign visitors at three Metro stations near the site of the
second China International Import Expo.The second China International
Import Expo will be held at the National Exhibition and Convention
Center in Shanghai from November 5 to 10, 2019.For further information
about China International Import Expo, please visit: https://www.shine.cn/China-International-Import-Expo/ or
https://www.shine.cn/ciie2019/v1.To get more ciie shanghai 2019 dates, you can visit shine news official website.
One of them is Xu Wenyi, who speaks English and Japanese. She works at East Xujing Station on Line 2 and can be found at Exits 4, 5 or 6.Xu said both Chinese and foreigners make inquiries about directions when arriving at the station.
“Many foreigners are not sure if they can get help from us. When I spot someone looking hesitant, I’ll come up to help,” she said.
Xu, who has been working as a police officer for nine years, normally works at the People’s Square Metro Station. Like many of her colleagues, she was assigned to work at East Xujing only for the expo, which is visited by hundreds of thousands of people.
With her knowledge of Japanese, she also provides translation support when Japanese speakers call police at the emergency number 110.
Xu is no stranger to big crowds at Metro stations. She said that People’s Square Station during the Chinese National Day holiday can be even more crowded.
Xu has two colleagues who speak foreign languages at East Xujing Station, while three other multilingual officers can be found at Zhuguang Road Station on Line 17 and the station of Hongqiao Railway Station on Lines 2, 10 and 17.
About 380 police officers and their assistants are working at the Metro stations of East Xujing, Zhuguang Road and Hongqiao Railway Station during the expo. The three stations typically have less than 20 police officers and assistants.
https://www.shine.cn/ciie2019/v1.To get more ciie shanghai 2019 dates, you can visit shine news official website.
One of them is Xu Wenyi, who speaks English and Japanese. She works at East Xujing Station on Line 2 and can be found at Exits 4, 5 or 6.Xu said both Chinese and foreigners make inquiries about directions when arriving at the station.
“Many foreigners are not sure if they can get help from us. When I spot someone looking hesitant, I’ll come up to help,” she said.
Xu, who has been working as a police officer for nine years, normally works at the People’s Square Metro Station. Like many of her colleagues, she was assigned to work at East Xujing only for the expo, which is visited by hundreds of thousands of people.
With her knowledge of Japanese, she also provides translation support when Japanese speakers call police at the emergency number 110.
Xu is no stranger to big crowds at Metro stations. She said that People’s Square Station during the Chinese National Day holiday can be even more crowded.
Xu has two colleagues who speak foreign languages at East Xujing Station, while three other multilingual officers can be found at Zhuguang Road Station on Line 17 and the station of Hongqiao Railway Station on Lines 2, 10 and 17.
About 380 police officers and their assistants are working at the Metro stations of East Xujing, Zhuguang Road and Hongqiao Railway Station during the expo. The three stations typically have less than 20 police officers and assistants.
A promotion meeting on trade in services for the Belt and Road regions,
an important supplement of the second China International Import Expo,
was held on Thursday.The second China International Import Expo will be
held at the National Exhibition and Convention Center in Shanghai from
November 5 to 10, 2019.For further information about China International
Import Expo, please visit: https://www.shine.cn/China-International-Import-Expo/ or
https://www.shine.cn/ciie2019/v1.To get more ciie china 2019, you can visit shine news official website.
The meeting aimed to acquaint participating enterprises with the latest policies on trade in services, offer them a chance to showcase their major service trade projects, and served as a platform for domestic and foreign companies to build connections.
Trade in services is playing an increasingly important role in the world's economy and has become a new source of momentum for the development of foreign trade, said Shanghai vice mayor Xu Kunlin.
"Openness is the biggest advantage of Shanghai, and the opening up of the service sector is among the top priorities," Xu said.
In 2018, the city's total foreign service trade approximated US$200 billion in total. This year, Shanghai issued 40 new measures for a new round of opening up in the service sector in August.
The city's Commission of Commerce has in recent years compiled a series of reports on service trade development and guidelines for key overseas markets, introducing countries along the Belt and Road.
The reports help Chinese service enterprises to strengthen cooperation with these regions and to seize business opportunities in the Belt and Road areas.
At today's meeting, such a report for the United Arab Emirates was officially released, providing a comprehensive overview of the UAE's trade in services.
Nearly 400 representatives of government authorities and businesses from thirteen countries (Belarus, Tajikistan, Kyrgyzstan, Russia, Turkmenistan, Ukraine, Germany, Mongolia, Nepal, Bangladesh, Kenya, Colombia, Barbados) attended the meeting.
https://www.shine.cn/ciie2019/v1.To get more ciie china 2019, you can visit shine news official website.
The meeting aimed to acquaint participating enterprises with the latest policies on trade in services, offer them a chance to showcase their major service trade projects, and served as a platform for domestic and foreign companies to build connections.
Trade in services is playing an increasingly important role in the world's economy and has become a new source of momentum for the development of foreign trade, said Shanghai vice mayor Xu Kunlin.
"Openness is the biggest advantage of Shanghai, and the opening up of the service sector is among the top priorities," Xu said.
In 2018, the city's total foreign service trade approximated US$200 billion in total. This year, Shanghai issued 40 new measures for a new round of opening up in the service sector in August.
The city's Commission of Commerce has in recent years compiled a series of reports on service trade development and guidelines for key overseas markets, introducing countries along the Belt and Road.
The reports help Chinese service enterprises to strengthen cooperation with these regions and to seize business opportunities in the Belt and Road areas.
At today's meeting, such a report for the United Arab Emirates was officially released, providing a comprehensive overview of the UAE's trade in services.
Nearly 400 representatives of government authorities and businesses from thirteen countries (Belarus, Tajikistan, Kyrgyzstan, Russia, Turkmenistan, Ukraine, Germany, Mongolia, Nepal, Bangladesh, Kenya, Colombia, Barbados) attended the meeting.
This introductory course is designed to acquaint students with the basic
elements of film production. Students are taught the aesthetics and
techniques required for producing a short narrative film. They are also
introduced to techniques in producing, writing, cinematography,
directing, and editing. Students are required to write, produce, and
direct a short film. Note: Students are required to share in the
expenses involved in their productions.wisepoqder CMS121
Course Goals: Upon successful completion of this course, students should be able to do the following:
develop a storyboard and script for a short film from an original idea;
utilize cinematographic techniques to convey meaning and create visual interest in a short film;
plan and implement a film shoot with a variety of crew roles; and
edit filmed scenes into a short narrative or experimental film.
Course Goals: Upon successful completion of this course, students should be able to do the following:
develop a storyboard and script for a short film from an original idea;
utilize cinematographic techniques to convey meaning and create visual interest in a short film;
plan and implement a film shoot with a variety of crew roles; and
edit filmed scenes into a short narrative or experimental film.
This Phase I clinical study will assess the safety and pharmacokinetics
of the experimental drug J147 in healthy adults. Researchers are
investigating the drug as a potential treatment for Alzheimer's disease.wisepoqder J147 powder
Exclusion Criteria
History or evidence of heart, endocrine, blood, immune, gastrointestinal, genital, urinary, or other body system disease
History or evidence of disease or dysfunction in neurological or psychiatric system that is likely to affect study results
Any disorder that would interfere with the absorption, distribution, metabolism, or excretion of drugs
Any concurrent disease or condition that would make the participant unsuitable for study participation
Positive for hepatitis B surface antigen, hepatitis C antibody, or HIV antibodies
Positive test for ethanol (alcohol) or cotinine (tobacco) at screening or admission
Positive urine drug test (e.g., cocaine, amphetamines, barbiturates, opiates, benzodiazepines, cannabinoids) at screening or admission
Is unwilling to avoid consumption of grapefruit, Seville oranges, or other products containing grapefruit or Seville oranges within 14 days of taking the study drug
History of alcohol and/or illicit drug abuse in past year or is unwilling to avoid use of alcohol or alcohol-containing foods, medications, or beverages within 48 hours of admission until discharge from the clinical unit
Has donated blood or blood products within 30 days of first dosing
Requires treatment with any prescription drugs or over-the-counter medications, including vitamins (large doses), dietary supplements, or herbal medications, within 14 days of study medication (acetaminophen 1,000 mg per day and recommended daily doses of vitamins are permitted)
Has received any known liver or kidney clearance altering agents (e.g., erythromycin, cimetidine, barbiturates, phenothiazines, or St. John's wort) within 30 days of study start
Has used an investigational drug within 30 days of screening
Hypersensitivity or allergies to J147, any of its components, or any drug within the same class
Significant abnormal vital signs on physical exam or laboratory results
Is considering or has scheduled any surgical procedure during study participation
Requires a special diet or has a significant food allergy or intolerance (vegetarian diet may be permitted)
Currently enrolled in another clinical study
Evidence of cognitive decline that is greater than expected for participant's age or changes in level of independence in everyday life
Detailed Description
J147 is a synthetic derivative of curcumin, a component of the curry spice turmeric. In this study participants will be randomly assigned to take either the study drug or a placebo in an escalating dose. Doses will first be given to younger participants after an 8-hour fast. Older participants will then receive doses that have been found to be safe in younger participants.
Exclusion Criteria
History or evidence of heart, endocrine, blood, immune, gastrointestinal, genital, urinary, or other body system disease
History or evidence of disease or dysfunction in neurological or psychiatric system that is likely to affect study results
Any disorder that would interfere with the absorption, distribution, metabolism, or excretion of drugs
Any concurrent disease or condition that would make the participant unsuitable for study participation
Positive for hepatitis B surface antigen, hepatitis C antibody, or HIV antibodies
Positive test for ethanol (alcohol) or cotinine (tobacco) at screening or admission
Positive urine drug test (e.g., cocaine, amphetamines, barbiturates, opiates, benzodiazepines, cannabinoids) at screening or admission
Is unwilling to avoid consumption of grapefruit, Seville oranges, or other products containing grapefruit or Seville oranges within 14 days of taking the study drug
History of alcohol and/or illicit drug abuse in past year or is unwilling to avoid use of alcohol or alcohol-containing foods, medications, or beverages within 48 hours of admission until discharge from the clinical unit
Has donated blood or blood products within 30 days of first dosing
Requires treatment with any prescription drugs or over-the-counter medications, including vitamins (large doses), dietary supplements, or herbal medications, within 14 days of study medication (acetaminophen 1,000 mg per day and recommended daily doses of vitamins are permitted)
Has received any known liver or kidney clearance altering agents (e.g., erythromycin, cimetidine, barbiturates, phenothiazines, or St. John's wort) within 30 days of study start
Has used an investigational drug within 30 days of screening
Hypersensitivity or allergies to J147, any of its components, or any drug within the same class
Significant abnormal vital signs on physical exam or laboratory results
Is considering or has scheduled any surgical procedure during study participation
Requires a special diet or has a significant food allergy or intolerance (vegetarian diet may be permitted)
Currently enrolled in another clinical study
Evidence of cognitive decline that is greater than expected for participant's age or changes in level of independence in everyday life
Detailed Description
J147 is a synthetic derivative of curcumin, a component of the curry spice turmeric. In this study participants will be randomly assigned to take either the study drug or a placebo in an escalating dose. Doses will first be given to younger participants after an 8-hour fast. Older participants will then receive doses that have been found to be safe in younger participants.
Alpha-lipoic acid has gained a lot of attention in recent years.It’s an
organic compound that acts as a powerful antioxidant in the body.Your
body produces alpha-lipoic acid naturally, but it’s also found in a
variety of foods and as a dietary supplement.Research suggests that it
may play a role in weight loss, diabetes, and other health conditions.
However, many people wonder whether it’s effective.This article reviews alpha-lipoic acid, its benefits, side effects, and recommended dosage.wisepoqder Alpha-lipoic Acid
What is alpha-lipoic acid?
Alpha-lipoic acid is an organic compound found in all human cells.It’s made inside the mitochondrion — also known as the powerhouse of cells — where it helps enzymes turn nutrients into energy (1).What’s more, it has powerful antioxidant properties.
Alpha-lipoic acid is both water- and fat-soluble, which allows it to work in every cell or tissue in the body. Meanwhile, most other antioxidants are either water- or fat-soluble (2).For instance, vitamin C is only water-soluble, while vitamin E is only fat-soluble.
The antioxidant properties of alpha-lipoic acid have been linked to several benefits, including lower blood sugar levels, reduced inflammation, slowed skin aging, and improved nerve function.Humans only produce alpha-lipoic acid in small amounts. That’s why many turn to certain foods or supplements to optimize their intake.
Animal products like red meat and organ meats are great sources of alpha-lipoic acid, but plant foods like broccoli, tomatoes, spinach, and Brussels sprouts also contain it.That said, supplements can pack up to 1,000 times more alpha-lipoic acid than food sources (3).
Alpha-lipoic acid and weight loss
Research has shown that alpha-lipoic acid may affect weight loss in several ways.Animal studies indicate that it can reduce the activity of the enzyme AMP-activated protein kinase (AMPK), which is located in your brain’s hypothalamus (4, 5).
When AMPK is more active, it may increase feelings of hunger.On the other hand, suppressing AMPK activity may increase the number of calories your body burns at rest. Thus, animals who took alpha-lipoic acid burned more calories (6, 7).
However, human studies show that alpha-lipoic acid only slightly impacts weight loss.An analysis of 12 studies discovered that people who took an alpha-lipoic acid supplement lost an average of 1.52 pounds (0.69 kg) more than those taking a placebo over an average of 14 weeks (8).In the same analysis, alpha-lipoic acid did not significantly affect waist circumference.
Another analysis of 12 studies found that people who took alpha-lipoic acid lost an average of 2.8 pounds (1.27 kg) more than those taking a placebo over an average of 23 weeks (9).In short, it seems that alpha-lipoic acid has just a slight effect on weight loss in humans.
However, many people wonder whether it’s effective.This article reviews alpha-lipoic acid, its benefits, side effects, and recommended dosage.wisepoqder Alpha-lipoic Acid
What is alpha-lipoic acid?
Alpha-lipoic acid is an organic compound found in all human cells.It’s made inside the mitochondrion — also known as the powerhouse of cells — where it helps enzymes turn nutrients into energy (1).What’s more, it has powerful antioxidant properties.
Alpha-lipoic acid is both water- and fat-soluble, which allows it to work in every cell or tissue in the body. Meanwhile, most other antioxidants are either water- or fat-soluble (2).For instance, vitamin C is only water-soluble, while vitamin E is only fat-soluble.
The antioxidant properties of alpha-lipoic acid have been linked to several benefits, including lower blood sugar levels, reduced inflammation, slowed skin aging, and improved nerve function.Humans only produce alpha-lipoic acid in small amounts. That’s why many turn to certain foods or supplements to optimize their intake.
Animal products like red meat and organ meats are great sources of alpha-lipoic acid, but plant foods like broccoli, tomatoes, spinach, and Brussels sprouts also contain it.That said, supplements can pack up to 1,000 times more alpha-lipoic acid than food sources (3).
Alpha-lipoic acid and weight loss
Research has shown that alpha-lipoic acid may affect weight loss in several ways.Animal studies indicate that it can reduce the activity of the enzyme AMP-activated protein kinase (AMPK), which is located in your brain’s hypothalamus (4, 5).
When AMPK is more active, it may increase feelings of hunger.On the other hand, suppressing AMPK activity may increase the number of calories your body burns at rest. Thus, animals who took alpha-lipoic acid burned more calories (6, 7).
However, human studies show that alpha-lipoic acid only slightly impacts weight loss.An analysis of 12 studies discovered that people who took an alpha-lipoic acid supplement lost an average of 1.52 pounds (0.69 kg) more than those taking a placebo over an average of 14 weeks (8).In the same analysis, alpha-lipoic acid did not significantly affect waist circumference.
Another analysis of 12 studies found that people who took alpha-lipoic acid lost an average of 2.8 pounds (1.27 kg) more than those taking a placebo over an average of 23 weeks (9).In short, it seems that alpha-lipoic acid has just a slight effect on weight loss in humans.
Alpha-lipoic acid or ALA is a naturally occurring compound that's made
in the body. It serves vital functions at the cellular level, such as
energy production. As long as you're healthy, the body can produce all
the ALA it needs for these purposes. Despite that fact, there has been a
lot of recent interest in using ALA supplements. Advocates of ALA make
claims that range from beneficial effects for treating conditions such
as diabetes and HIV to enhancing weight loss.wisepoqder Alpha-lipoic Acid powder
Research on the effects of ALA supplementation is sparse. What there is, though, does suggest some possible benefits. Here is what's known about the potential health benefits of using alpha-lipoic acid supplements.
ALA is an antioxidant. Antioxidants protect against damage to the body's cells.
There are food sources of ALA such as yeast, organ meats like liver and heart, spinach, broccoli, and potatoes. However, ALA from food does not appear to produce a noticeable increase in the level of free ALA in the body.Some people take ALA supplements with the intent to improve a variety of health conditions. Scientific evidence for the health benefit of supplemental ALA has been inconclusive.
Studies show that about 30% to 40% of the oral dose of an ALA supplement is absorbed. ALA may be better absorbed if it is taken on an empty stomach.
While studies are still sparse, there is some evidence that ALA may have at least two positive benefits for individuals with type 2 diabetes. A few studies have suggested that alpha-lipoic acid supplements may enhance the body's ability to use its own insulin to lower blood sugar in people with type 2 diabetes. ALA may help reduce the symptoms of peripheral neuropathy -- nerve damage that can be caused by diabetes.
In Europe, ALA has been used for years to provide relief from the pain, burning, tingling, and numbing caused by diabetic neuropathy. In particular, one large study strongly suggested that large intravenous doses of ALA were effective at relieving symptoms. But the evidence for oral doses is not as strong. More research is needed to establish the effectiveness of oral ALA supplements for diabetic neuropathy.
Research on the effects of ALA supplementation is sparse. What there is, though, does suggest some possible benefits. Here is what's known about the potential health benefits of using alpha-lipoic acid supplements.
ALA is an antioxidant. Antioxidants protect against damage to the body's cells.
There are food sources of ALA such as yeast, organ meats like liver and heart, spinach, broccoli, and potatoes. However, ALA from food does not appear to produce a noticeable increase in the level of free ALA in the body.Some people take ALA supplements with the intent to improve a variety of health conditions. Scientific evidence for the health benefit of supplemental ALA has been inconclusive.
Studies show that about 30% to 40% of the oral dose of an ALA supplement is absorbed. ALA may be better absorbed if it is taken on an empty stomach.
While studies are still sparse, there is some evidence that ALA may have at least two positive benefits for individuals with type 2 diabetes. A few studies have suggested that alpha-lipoic acid supplements may enhance the body's ability to use its own insulin to lower blood sugar in people with type 2 diabetes. ALA may help reduce the symptoms of peripheral neuropathy -- nerve damage that can be caused by diabetes.
In Europe, ALA has been used for years to provide relief from the pain, burning, tingling, and numbing caused by diabetic neuropathy. In particular, one large study strongly suggested that large intravenous doses of ALA were effective at relieving symptoms. But the evidence for oral doses is not as strong. More research is needed to establish the effectiveness of oral ALA supplements for diabetic neuropathy.
L-arginine, an amino acid, is found in foods like dairy products and
meats. It helps in bodybuilding, muscle development, and improved
performance.
These benefits have been researched with most conclusions being made after extensive studies.One study showed that L-arginine improves DNA synthesis and mitochondrial bioenergetics, which may also be responsible for the beneficial effects of Arg on intestinal mucosal cells.wisepoqder L(+)-Arginine
L-arginine is produced by the body in adequate amounts to elevate the action of a nitric acid in the body. It also has biochemical components that enhance the metabolism of fats.It is mostly given to people dealing with obesity to help burn the fat and enhance the formation of muscle mass. Supplementing with l-arginine allows your body to use accumulated fats as a source of energy.
The accumulated fat is burnt to produce energy and to aid in muscle mass formation and development. L-arginine thus boosts your body metabolism as well as forms building blocks for muscle formation.As a result, you lose fat mass but retain your muscle mass.
To test the efficacy of l-arginine on weight loss, a research study was conducted. L-arginine supplements were given to obese males who had type 2 diabetes to see if it would help in weight loss.
The study had more than 300 subjects who were subjected to the l-arginine and placebo groups.They consumed 1000kcal per day and exercised 90 minutes every day for five days in a week. They also took 8.3g of l-arginine per day.
The results from the 21-day study showed that l-arginine increases weight loss. People who got l-arginine showed that 100 percent of the weight loss was all fat compared to those on placebo who lost up to 40 percent muscle mass.
Larger doses of l-arginine for weight loss allow for faster fat burning, which is needed in the development of a leaner body:
The upper recommended l-arginine amount per serving is 5 to 10 grams. You should start with a lower serving and increase the dosage as you continue to use the supplement. It stimulates more body fat burning and formation of muscle, thus making it ideal for people looking to lose weight.
This supplement is highly effective in the treatment of obesity. However, excessive use can lead to harmful side effects.Amino acids are known to aid in bodybuilding. For instance, l-arginine minimizes the action of the adipose tissue, which is the belly fat. Obesity is mainly characterized by stores of belly fat. The more a person accumulates the belly fat, the higher the risk of developing cardiovascular diseases.
Stimulates production of HGH
L-arginine also increases the levels of HGH (Human Growth Hormone) that supports increased metabolism. However, it increases HGH levels when taken in very large amounts. Taking large amounts of the supplement is not advisable, however, because it can cause side effects such as stomach cramps and diarrhea.
Increased energy:
Additionally, l-arginine is an ingredient long used in supplement formulas. It has been used for a wide range of functions including the enhancement of sports performance and boosting cardiovascular health. Since it is a nitrogenous acid, it stimulates the production of a nitric oxide whose making function is to dilate the blood vessels. Increased blood flow through the body increases energy and enhances the overall body performance.
Dilated vessels ease the work of the heart, thus improving your cardiovascular health by lowering your blood pressure. They also transport blood faster to different pressure points, which increases your energy for workouts.
Besides increasing your energy, dilated blood vessels also act as a treatment basis for erectile dysfunction.Some studies have pointed out that it increases semen production, implying that could boost sexual performance. It prevents renal dysfunction in patients with type- 2 diabetes.
These benefits have been researched with most conclusions being made after extensive studies.One study showed that L-arginine improves DNA synthesis and mitochondrial bioenergetics, which may also be responsible for the beneficial effects of Arg on intestinal mucosal cells.wisepoqder L(+)-Arginine
L-arginine is produced by the body in adequate amounts to elevate the action of a nitric acid in the body. It also has biochemical components that enhance the metabolism of fats.It is mostly given to people dealing with obesity to help burn the fat and enhance the formation of muscle mass. Supplementing with l-arginine allows your body to use accumulated fats as a source of energy.
The accumulated fat is burnt to produce energy and to aid in muscle mass formation and development. L-arginine thus boosts your body metabolism as well as forms building blocks for muscle formation.As a result, you lose fat mass but retain your muscle mass.
To test the efficacy of l-arginine on weight loss, a research study was conducted. L-arginine supplements were given to obese males who had type 2 diabetes to see if it would help in weight loss.
The study had more than 300 subjects who were subjected to the l-arginine and placebo groups.They consumed 1000kcal per day and exercised 90 minutes every day for five days in a week. They also took 8.3g of l-arginine per day.
The results from the 21-day study showed that l-arginine increases weight loss. People who got l-arginine showed that 100 percent of the weight loss was all fat compared to those on placebo who lost up to 40 percent muscle mass.
Larger doses of l-arginine for weight loss allow for faster fat burning, which is needed in the development of a leaner body:
The upper recommended l-arginine amount per serving is 5 to 10 grams. You should start with a lower serving and increase the dosage as you continue to use the supplement. It stimulates more body fat burning and formation of muscle, thus making it ideal for people looking to lose weight.
This supplement is highly effective in the treatment of obesity. However, excessive use can lead to harmful side effects.Amino acids are known to aid in bodybuilding. For instance, l-arginine minimizes the action of the adipose tissue, which is the belly fat. Obesity is mainly characterized by stores of belly fat. The more a person accumulates the belly fat, the higher the risk of developing cardiovascular diseases.
Stimulates production of HGH
L-arginine also increases the levels of HGH (Human Growth Hormone) that supports increased metabolism. However, it increases HGH levels when taken in very large amounts. Taking large amounts of the supplement is not advisable, however, because it can cause side effects such as stomach cramps and diarrhea.
Increased energy:
Additionally, l-arginine is an ingredient long used in supplement formulas. It has been used for a wide range of functions including the enhancement of sports performance and boosting cardiovascular health. Since it is a nitrogenous acid, it stimulates the production of a nitric oxide whose making function is to dilate the blood vessels. Increased blood flow through the body increases energy and enhances the overall body performance.
Dilated vessels ease the work of the heart, thus improving your cardiovascular health by lowering your blood pressure. They also transport blood faster to different pressure points, which increases your energy for workouts.
Besides increasing your energy, dilated blood vessels also act as a treatment basis for erectile dysfunction.Some studies have pointed out that it increases semen production, implying that could boost sexual performance. It prevents renal dysfunction in patients with type- 2 diabetes.