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Women taking a new breast cancer drug are living longer than those taking Tamoxifen - the current 'gold standard' treatment.
Doctors predict the new drug, Arimidex, will improve long-term survival for women using hormonal therapy for the first time in decades.Tamoxifen
Claimed as the biggest breakthrough in treatment for 20 years, it is the first drug to challenge tamoxifen, the standard treatment for postmenopausal women after surgery.
Trial results out yesterday show the risk of a relapse within four years of surgery is cut by almost a fifth more in women taking Arimidex.
Only 413 of 3,125 women taking the new drug had a breast cancer relapse or died compared with 472 of 3,116 women using tamoxifen.
The latest research findings show Arimidex is much more effective than tamoxifen, which is normally used to stop patients successfully treated with surgery from developing a tumour in the other breast.
Previous trial results found that although tamoxifen halves the risk of a new cancer in the other breast - Arimidex halves it again.
Women taking Arimidex also suffer fewer cases of deep vein thrombosis and womb cancer - known sideeffects of tamoxifen use.
Professor Jeffrey Tobias, Professor of Cancer Medicine at University College and Middlesex School of Medicine and one of the trial investigators, said: 'The results show that women taking Arimidex remain disease-free for longer than those on tamoxifen - so far we have observed fewer recurrences and a longer time before relapse in these patients.'
The study of 9,300 post-menopausal women worldwide, including 3,000 Britons, involves women being given Arimidex, tamoxifen or both.
It shows that women with tumours that respond to hormonal therapy have an 18 per cent lower risk of a relapse after about four years of treatment, according to results released at the San Antonio Breast Cancer Symposium, Texas.
Doctors predict the new drug, Arimidex, will improve long-term survival for women using hormonal therapy for the first time in decades.Tamoxifen
Claimed as the biggest breakthrough in treatment for 20 years, it is the first drug to challenge tamoxifen, the standard treatment for postmenopausal women after surgery.
Trial results out yesterday show the risk of a relapse within four years of surgery is cut by almost a fifth more in women taking Arimidex.
Only 413 of 3,125 women taking the new drug had a breast cancer relapse or died compared with 472 of 3,116 women using tamoxifen.
The latest research findings show Arimidex is much more effective than tamoxifen, which is normally used to stop patients successfully treated with surgery from developing a tumour in the other breast.
Previous trial results found that although tamoxifen halves the risk of a new cancer in the other breast - Arimidex halves it again.
Women taking Arimidex also suffer fewer cases of deep vein thrombosis and womb cancer - known sideeffects of tamoxifen use.
Professor Jeffrey Tobias, Professor of Cancer Medicine at University College and Middlesex School of Medicine and one of the trial investigators, said: 'The results show that women taking Arimidex remain disease-free for longer than those on tamoxifen - so far we have observed fewer recurrences and a longer time before relapse in these patients.'
The study of 9,300 post-menopausal women worldwide, including 3,000 Britons, involves women being given Arimidex, tamoxifen or both.
It shows that women with tumours that respond to hormonal therapy have an 18 per cent lower risk of a relapse after about four years of treatment, according to results released at the San Antonio Breast Cancer Symposium, Texas.
Tamoxifens is very comparable to Clomid, behaves in the same manner in
all tissues, and is a mixed estrogen agonist/antagonist of the same type
as Clomid. The two molecules are also very similar in structure. It is
not correct that Tamoxifens reduces levels of estrogen: Rather, it
blocks estrogen from estrogen receptors and, in those tissues where it
is an antagonist, causes the receptor to do nothing.β-agonist Powder
The claim that Tamoxifens reduces gains should not be taken too seriously. The fact is that any number of bodybuilders have made excellent gains while using Tamoxifens.
The belief that it reduces gains seems to stem from the fact that the scientific literature reports a slight reduction (individuals using anabolic steroids were not studied though) from use of Tamoxifens.
What is it application:
is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifens. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. is the usual endocrine (anti-estrogen) therapy forhormonereceptor-positivebreast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting.
is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Because of this competitive antagonism, acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.
The note of Tamoxifens:
1. Before using this medicine, tell your doctor about any disease, especially prostate cancer or breast cancer (male), liver, heart, kidney disease, allergies, and enlarged prostate cancer. High - dose, long - term use of male hormones, liver cancer;
2. This medicine can not be used during pregnancy. If you are pregnant or think you may be pregnant, immediately notify your doctor. Breastfeeding at the same time, should avoid using this drug;
3. Women should monitor masculine signs such as deepening of sound, beard, acne, irregular menstruation, or clitoral enlargement. If any of these occurs, consult your doctor in a timely manner;
4. Children should be very cautious, because the drug may have adverse effects on child development. Older men use this drug, there is prostate enlargement or prostate cancer risk.
The claim that Tamoxifens reduces gains should not be taken too seriously. The fact is that any number of bodybuilders have made excellent gains while using Tamoxifens.
The belief that it reduces gains seems to stem from the fact that the scientific literature reports a slight reduction (individuals using anabolic steroids were not studied though) from use of Tamoxifens.
What is it application:
is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifens. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. is the usual endocrine (anti-estrogen) therapy forhormonereceptor-positivebreast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting.
is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Because of this competitive antagonism, acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.
The note of Tamoxifens:
1. Before using this medicine, tell your doctor about any disease, especially prostate cancer or breast cancer (male), liver, heart, kidney disease, allergies, and enlarged prostate cancer. High - dose, long - term use of male hormones, liver cancer;
2. This medicine can not be used during pregnancy. If you are pregnant or think you may be pregnant, immediately notify your doctor. Breastfeeding at the same time, should avoid using this drug;
3. Women should monitor masculine signs such as deepening of sound, beard, acne, irregular menstruation, or clitoral enlargement. If any of these occurs, consult your doctor in a timely manner;
4. Children should be very cautious, because the drug may have adverse effects on child development. Older men use this drug, there is prostate enlargement or prostate cancer risk.
Albuterol is used to treat or prevent bronchospasm in patients with
asthma, bronchitis, emphysema, and other lung diseases. It is also used
to prevent bronchospasm caused by exercise.β-agonist Powder
Albuterol belongs to the family of medicines known as adrenergic bronchodilators. Adrenergic bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of albuterol inhalation aerosol (eg, ProAir® HFA, Proventil® HFA) in children 4 years of age and older, albuterol inhalation powder (eg, ProAir® Respiclick®) in children 4 years of age and older, and albuterol inhalation solution (eg, Accuneb®) in children 2 years of age and older. However, safety and efficacy have not been established for the albuterol inhalation aerosol and albuterol inhalation powder in children younger than 4 years of age, and albuterol inhalation solution in children younger than 2 years of age.
Geriatric
Appropriate studies have not been performed on the relationship of age to the effects of Proventil® HFA in the geriatric population. However, elderly patients are more likely to have age-related heart problems, which may require caution in the dose for patients receiving Proventil® HFA.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ProAir® HFA and ProAir® Respiclick® in geriatric patients. However, elderly patients are more likely to have age-related heart, kidney, or liver problems, which may require caution and an adjustment in the dose for patients receiving ProAir® HFA and ProAir® Respiclick®.
No information is available on the relationship of age to the effects of albuterol inhalation solution (eg, Accuneb®) in geriatric patients.
Albuterol belongs to the family of medicines known as adrenergic bronchodilators. Adrenergic bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of albuterol inhalation aerosol (eg, ProAir® HFA, Proventil® HFA) in children 4 years of age and older, albuterol inhalation powder (eg, ProAir® Respiclick®) in children 4 years of age and older, and albuterol inhalation solution (eg, Accuneb®) in children 2 years of age and older. However, safety and efficacy have not been established for the albuterol inhalation aerosol and albuterol inhalation powder in children younger than 4 years of age, and albuterol inhalation solution in children younger than 2 years of age.
Geriatric
Appropriate studies have not been performed on the relationship of age to the effects of Proventil® HFA in the geriatric population. However, elderly patients are more likely to have age-related heart problems, which may require caution in the dose for patients receiving Proventil® HFA.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ProAir® HFA and ProAir® Respiclick® in geriatric patients. However, elderly patients are more likely to have age-related heart, kidney, or liver problems, which may require caution and an adjustment in the dose for patients receiving ProAir® HFA and ProAir® Respiclick®.
No information is available on the relationship of age to the effects of albuterol inhalation solution (eg, Accuneb®) in geriatric patients.
Product Name: Albuterol sulfate
CAS: 51022-70-9
MF: C13H23NO7S
MW: 337.39
EINECS: 242-424-0
Mol File: 51022-70-9.mol
Chemical Properties: White Crystalline Solid
Usage: Adrenergic agonist
Usage: A 2-adrenoceptor agonist. Bronchodilator; tocolytic.
Usage: Bronchodilator, antiasthmatic
Assay: 99%
Packing: 1kg/bag
Albuterol is a bronchodilator that relaxes muscles in the airways and increases air flow to the lungs.Albuterol inhalation is used to treat or prevent bronchospasm in people with reversible obstructive airway disease. It is also used to prevent exercise-induced bronchospasm.Salbutamol
Albuterol sulfate is a prescription medication indicated to treat or prevent airway constriction in people with asthma. This medication is a bronchodilator, which works by relaxing the bronchial muscles within a patient's airways to allow oxygen to reach the lungs. In certain instances, patients can develop allergic reaction symptoms after taking albuterol sulfate for the first time. Affected patients require immediate, emergency medical attention to avoid developing potentially life-threatening medical complications.
Albuterol Sulfateis usually given by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a metered dose inhaler (MDI), nebulizer or other proprietary delivery devices (e.g. Rotahaler or Autohaler). In these forms of delivery, the maximal effect of salbutamol can take place within five to 20 minutes of dosing, though some relief is immediately seen. It can also be given intravenously.Used in the treatment of bronchial asthma, asthmatic bronchitis, emphysema, patients bronchospasm.
CAS: 51022-70-9
MF: C13H23NO7S
MW: 337.39
EINECS: 242-424-0
Mol File: 51022-70-9.mol
Chemical Properties: White Crystalline Solid
Usage: Adrenergic agonist
Usage: A 2-adrenoceptor agonist. Bronchodilator; tocolytic.
Usage: Bronchodilator, antiasthmatic
Assay: 99%
Packing: 1kg/bag
Albuterol is a bronchodilator that relaxes muscles in the airways and increases air flow to the lungs.Albuterol inhalation is used to treat or prevent bronchospasm in people with reversible obstructive airway disease. It is also used to prevent exercise-induced bronchospasm.Salbutamol
Albuterol sulfate is a prescription medication indicated to treat or prevent airway constriction in people with asthma. This medication is a bronchodilator, which works by relaxing the bronchial muscles within a patient's airways to allow oxygen to reach the lungs. In certain instances, patients can develop allergic reaction symptoms after taking albuterol sulfate for the first time. Affected patients require immediate, emergency medical attention to avoid developing potentially life-threatening medical complications.
Albuterol Sulfateis usually given by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a metered dose inhaler (MDI), nebulizer or other proprietary delivery devices (e.g. Rotahaler or Autohaler). In these forms of delivery, the maximal effect of salbutamol can take place within five to 20 minutes of dosing, though some relief is immediately seen. It can also be given intravenously.Used in the treatment of bronchial asthma, asthmatic bronchitis, emphysema, patients bronchospasm.
A single 40-mg dose of oral propranolol, judiciously timed, constitutes
an outside-the-box yet highly promising treatment for anxiety disorders,
and perhaps for posttraumatic stress disorder as well, Marieke Soeter,
PhD, said at the annual congress of the European College of
Neuropsychopharmacology.
The concept here is that the beta-blocker, when given with a brief therapist-led reactivation of a fear memory, blocks beta-adrenergic receptors in the brain so as to interfere with the specific proteins required for reconsolidation of that memory, thereby disrupting the reconsolidation process and neutralizing subsequent expression of that memory in its toxic form. In effect, timely administration of one dose of propranolol, a drug that readily crosses the blood/brain barrier, achieves pharmacologically induced amnesia regarding the learned fear, explained Dr. Soeter, a clinical psychologist at TNO, the Netherlands Organization for Scientific Research, an independent nonprofit translational research organization.Propanolol powder
“It looks like permanent fear erasure. You can never say that something is erased, but we have not been able to get it back,” she said. “Propranolol achieves selective erasure: It targets the emotional component, but knowledge is intact. They know what happened, but they aren’t scared anymore. The fear association is affected, but not the innate fear response to a threat stimulus, so it doesn’t alter reactions to potentially dangerous situations, which is important. If there is a bomb, they still know to run away from it.
This single-session therapy addressing what psychologists call fear memory reconsolidation is totally outside the box relative to contemporary psychotherapy for anxiety disorders, which typically entails gradual fear extinction learning requiring multiple treatment sessions. But contemporary psychotherapy for anxiety disorders leaves much room for improvement, given that up to 60% of patients experience relapse. That’s probably because the original fear memory remains intact and resurfaces at some point despite initial treatment success, according to Dr. Soeter.
Nearly 2 decades ago, other investigators showed in animal studies that fear memories are not necessarily permanent. Rather, they are modifiable, and even erasable, during the vulnerable period that occurs when the memories are reactivated and become labile.
Later, Dr. Soeter – then at the University of Amsterdam – and her colleagues demonstrated the same phenomenon using Pavlovian fear-conditioning techniques involving pictures and electric shocks in healthy human volunteers. They showed that a dose of propranolol given before memory reactivation blocked the fear response, while nadolol, a beta-blocker that does not cross the blood/brain barrier, did not.
However, since the fear memories they could ethically induce in the psychology laboratory are far less intense than those experienced by patients with anxiety disorders, the researchers next conducted a randomized, double-blind clinical trial in 45 individuals with arachnophobia. Fifteen received 40 mg of propranolol after spending 2 minutes in proximity to a large tarantula, 15 got placebo, and another 15 received propranolol without exposure to a tarantula. One week later, all patients who received propranolol with spider exposure were able to approach and actually pet the tarantula. Pharmacologic disruption of reconsolidation and storage of their fear memory had turned avoidance behavior into approach behavior. This benefit was maintained for at least a year after the brief treatment session (Biol Psychiatry. 2015 Dec 15;78[12]:880-6).
The concept here is that the beta-blocker, when given with a brief therapist-led reactivation of a fear memory, blocks beta-adrenergic receptors in the brain so as to interfere with the specific proteins required for reconsolidation of that memory, thereby disrupting the reconsolidation process and neutralizing subsequent expression of that memory in its toxic form. In effect, timely administration of one dose of propranolol, a drug that readily crosses the blood/brain barrier, achieves pharmacologically induced amnesia regarding the learned fear, explained Dr. Soeter, a clinical psychologist at TNO, the Netherlands Organization for Scientific Research, an independent nonprofit translational research organization.Propanolol powder
“It looks like permanent fear erasure. You can never say that something is erased, but we have not been able to get it back,” she said. “Propranolol achieves selective erasure: It targets the emotional component, but knowledge is intact. They know what happened, but they aren’t scared anymore. The fear association is affected, but not the innate fear response to a threat stimulus, so it doesn’t alter reactions to potentially dangerous situations, which is important. If there is a bomb, they still know to run away from it.
This single-session therapy addressing what psychologists call fear memory reconsolidation is totally outside the box relative to contemporary psychotherapy for anxiety disorders, which typically entails gradual fear extinction learning requiring multiple treatment sessions. But contemporary psychotherapy for anxiety disorders leaves much room for improvement, given that up to 60% of patients experience relapse. That’s probably because the original fear memory remains intact and resurfaces at some point despite initial treatment success, according to Dr. Soeter.
Nearly 2 decades ago, other investigators showed in animal studies that fear memories are not necessarily permanent. Rather, they are modifiable, and even erasable, during the vulnerable period that occurs when the memories are reactivated and become labile.
Later, Dr. Soeter – then at the University of Amsterdam – and her colleagues demonstrated the same phenomenon using Pavlovian fear-conditioning techniques involving pictures and electric shocks in healthy human volunteers. They showed that a dose of propranolol given before memory reactivation blocked the fear response, while nadolol, a beta-blocker that does not cross the blood/brain barrier, did not.
However, since the fear memories they could ethically induce in the psychology laboratory are far less intense than those experienced by patients with anxiety disorders, the researchers next conducted a randomized, double-blind clinical trial in 45 individuals with arachnophobia. Fifteen received 40 mg of propranolol after spending 2 minutes in proximity to a large tarantula, 15 got placebo, and another 15 received propranolol without exposure to a tarantula. One week later, all patients who received propranolol with spider exposure were able to approach and actually pet the tarantula. Pharmacologic disruption of reconsolidation and storage of their fear memory had turned avoidance behavior into approach behavior. This benefit was maintained for at least a year after the brief treatment session (Biol Psychiatry. 2015 Dec 15;78[12]:880-6).
Product Name: Indapamide
CAS: 26807-65-8
Standard: Corporate Standard
Natural/Synthetic: Synthetic
Source of extraction: for export only
Level: Pharmaceutical grade
Content: 99%
Appearance: white powder
Packing: 25 / cardboard drum can be split
Field: Diuretic antihypertensive drugs
Deferred Products: Indapamide Tablets, Indapamide Capsules, Indapamide Sustained Release Tablets
Use: For the treatment of mild to moderate essential hypertension
Dosage: Adults: conventional oral dose 1. Hypertension: 2.5mg each time, once daily. It can be increased to 5 mg once daily after 4 weeks. The maintenance dose is 2.5mg each time, every other day. 2. Water and sodium retention: Each 2.5mg, once daily. It can be increased to 5 mg once daily after 1 week. Elderly dose: dosage.
High Quality Indapamide 99% CAS: 26807-65-8
Brief Introduction of Active Pharmaceutical Ingredients Indapamide:
1. Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.
2. White needle crystal or crystalline powder, odorless, tasteless. It is almost insoluble in water or dilute hydrochloric acid, while it can be dissolved in ethanol or ethyl acetate, and it is soluble in acetone, acetic acid, slightly soluble in chloroform or ether.
3. Indapamide is currently the most popular non-prescription diuretic antihypertensive drug with good efficacy, stable blood pressure, fewer side effects, etc.
Medical Application of Active Pharmaceutical Ingredients Indapamide:
1. This medication is used to treat high blood pressure. Indapamide is also used to reduce extra salt and fluid in the body (edema) caused by a certain heart problem (congestive heart failure). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Decreasing extra salt and fluid in the body helps to decrease swelling and breathing problems from congestive heart failure and increases your ability to exercise.
2. Indapamide is a "water pill" (diuretic) that increases the amount of urine you make. Getting rid of extra water and salt may help to relax the blood vessels so that bloodcan flow more easily. These effects help to lower blood pressure and decrease the amount of work the heart must do to pump blood.
Function of Active Pharmaceutical Ingredients Indapamide:
1. Indapamide have diuretic and calcium antagonist dual effect by inhibiting the proximal end of the distal convoluted tubule Na+ reabsorption, resulting in diuresis, while by blocking Ca2+ influx especially a higher selectivity for vascular smooth muscle to dilate the small blood vessels of the outer periphery, resulting in antihypertensive effect. But the effect to vascular smooth muscle is stronger than the diuretic effect.
2. It can lower blood pressure with lower dose compared to diuretic effect. Higher dose will display diuretic effect. But there is no disadvantage compared to thiazide diuretics, that it does not cause orthostatic hypotension, flushing and reflex tachycardia, nor blood lipids, glucose metabolism and renal function.
CAS: 26807-65-8
Standard: Corporate Standard
Natural/Synthetic: Synthetic
Source of extraction: for export only
Level: Pharmaceutical grade
Content: 99%
Appearance: white powder
Packing: 25 / cardboard drum can be split
Field: Diuretic antihypertensive drugs
Deferred Products: Indapamide Tablets, Indapamide Capsules, Indapamide Sustained Release Tablets
Use: For the treatment of mild to moderate essential hypertension
Dosage: Adults: conventional oral dose 1. Hypertension: 2.5mg each time, once daily. It can be increased to 5 mg once daily after 4 weeks. The maintenance dose is 2.5mg each time, every other day. 2. Water and sodium retention: Each 2.5mg, once daily. It can be increased to 5 mg once daily after 1 week. Elderly dose: dosage.
High Quality Indapamide 99% CAS: 26807-65-8
Brief Introduction of Active Pharmaceutical Ingredients Indapamide:
1. Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.
2. White needle crystal or crystalline powder, odorless, tasteless. It is almost insoluble in water or dilute hydrochloric acid, while it can be dissolved in ethanol or ethyl acetate, and it is soluble in acetone, acetic acid, slightly soluble in chloroform or ether.
3. Indapamide is currently the most popular non-prescription diuretic antihypertensive drug with good efficacy, stable blood pressure, fewer side effects, etc.
Medical Application of Active Pharmaceutical Ingredients Indapamide:
1. This medication is used to treat high blood pressure. Indapamide is also used to reduce extra salt and fluid in the body (edema) caused by a certain heart problem (congestive heart failure). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Decreasing extra salt and fluid in the body helps to decrease swelling and breathing problems from congestive heart failure and increases your ability to exercise.
2. Indapamide is a "water pill" (diuretic) that increases the amount of urine you make. Getting rid of extra water and salt may help to relax the blood vessels so that bloodcan flow more easily. These effects help to lower blood pressure and decrease the amount of work the heart must do to pump blood.
Function of Active Pharmaceutical Ingredients Indapamide:
1. Indapamide have diuretic and calcium antagonist dual effect by inhibiting the proximal end of the distal convoluted tubule Na+ reabsorption, resulting in diuresis, while by blocking Ca2+ influx especially a higher selectivity for vascular smooth muscle to dilate the small blood vessels of the outer periphery, resulting in antihypertensive effect. But the effect to vascular smooth muscle is stronger than the diuretic effect.
2. It can lower blood pressure with lower dose compared to diuretic effect. Higher dose will display diuretic effect. But there is no disadvantage compared to thiazide diuretics, that it does not cause orthostatic hypotension, flushing and reflex tachycardia, nor blood lipids, glucose metabolism and renal function.
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Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.
Indapamide is currently the most popular non-prescription diuretic antihypertensive drug with good efficacy, stable blood pressure, fewer side effects, etc.
Indapamide Application
Indapamide is used to treat high blood pressure. Indapamide is also used to reduce extra salt and fluid in the body (edema) caused by a certain heart problem (congestive heart failure). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Decreasing extra salt and fluid in the body helps to decrease swelling and breathing problems from congestive heart failure and increases your ability to exercise.
Indapamide have diuretic and calcium antagonist dual effect by inhibiting the proximal end of the distal convoluted tubule Na+ reabsorption, resulting in diuresis, while by blocking Ca2+ influx especially a higher selectivity for vascular smooth muscle to dilate the small blood vessels of the outer periphery, resulting in antihypertensive effect. But the effect to vascular smooth muscle is stronger than the diuretic effect.
Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.
Indapamide is currently the most popular non-prescription diuretic antihypertensive drug with good efficacy, stable blood pressure, fewer side effects, etc.
Indapamide Application
Indapamide is used to treat high blood pressure. Indapamide is also used to reduce extra salt and fluid in the body (edema) caused by a certain heart problem (congestive heart failure). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Decreasing extra salt and fluid in the body helps to decrease swelling and breathing problems from congestive heart failure and increases your ability to exercise.
Indapamide have diuretic and calcium antagonist dual effect by inhibiting the proximal end of the distal convoluted tubule Na+ reabsorption, resulting in diuresis, while by blocking Ca2+ influx especially a higher selectivity for vascular smooth muscle to dilate the small blood vessels of the outer periphery, resulting in antihypertensive effect. But the effect to vascular smooth muscle is stronger than the diuretic effect.
One bride uniquely asked her bridesmaids to sport their own wedding
gowns to her recent wedding — though she ultimately stole the show in an
ice blue frock.
Earlier this week, a photo of actress Audrey Moore and her 10 beaming bridesmaids went viral on Reddit, winning over 90,000 upvotes in four days.“We thought it was sad that most women only get to wear their wedding dress once, so we invited all the women coming to our non-traditional wedding to wear their old wedding dresses again!” Moore’s now-husband, writer Jesse Lumen, wrote on the social media forum platform.www.eisenge.com
Tying the knot on Dec. 30, the California bride told BuzzFeed that they wanted their wedding to authentically capture the playful spirit of their personalities.We really wanted our wedding to really represent ourselves, our sense of humor, our creativity, and also not just celebrate ourselves but marriage in general as a choice," Moore said of the special day.
With that vision in mind, she and her groom mandated a unique dress code, inviting all of the women in attendance to wear bridal gowns and the groomsmen to wear matching tuxedo-style hoodies, while also giving merrymakers the option of arriving in costume as well."I've been to all of their weddings and I saw them all in their beautiful dresses. I wanted them to have the opportunity to wear their really magical, beautiful dress a second time,” she told the outlet.
Though some Reddit users voiced concern that unwed female guests in attendance may have felt left out by the wedding gown dress code request, the bride told BBC that it was all in good fun."I'm the last one to be married in my group of friends. I was pretty much the last girl standing," she said, detailing that some unmarried women "wore their mother's wedding dress or put on a costume."In the days since, Moore and Lumen’s one-of-a-kind wedding day has won major applause on social media.
“I've filmed/edited well over 100 weddings. This is the coolest, most unique one I've ever seen,” one Reddit fan wrote online.“I would totally take this chance to be dressed as Darth Vadar at the wedding if you said I could wear a costume,” another agreed. “Best wedding ever!”
Earlier this week, a photo of actress Audrey Moore and her 10 beaming bridesmaids went viral on Reddit, winning over 90,000 upvotes in four days.“We thought it was sad that most women only get to wear their wedding dress once, so we invited all the women coming to our non-traditional wedding to wear their old wedding dresses again!” Moore’s now-husband, writer Jesse Lumen, wrote on the social media forum platform.www.eisenge.com
Tying the knot on Dec. 30, the California bride told BuzzFeed that they wanted their wedding to authentically capture the playful spirit of their personalities.We really wanted our wedding to really represent ourselves, our sense of humor, our creativity, and also not just celebrate ourselves but marriage in general as a choice," Moore said of the special day.
With that vision in mind, she and her groom mandated a unique dress code, inviting all of the women in attendance to wear bridal gowns and the groomsmen to wear matching tuxedo-style hoodies, while also giving merrymakers the option of arriving in costume as well."I've been to all of their weddings and I saw them all in their beautiful dresses. I wanted them to have the opportunity to wear their really magical, beautiful dress a second time,” she told the outlet.
Though some Reddit users voiced concern that unwed female guests in attendance may have felt left out by the wedding gown dress code request, the bride told BBC that it was all in good fun."I'm the last one to be married in my group of friends. I was pretty much the last girl standing," she said, detailing that some unmarried women "wore their mother's wedding dress or put on a costume."In the days since, Moore and Lumen’s one-of-a-kind wedding day has won major applause on social media.
“I've filmed/edited well over 100 weddings. This is the coolest, most unique one I've ever seen,” one Reddit fan wrote online.“I would totally take this chance to be dressed as Darth Vadar at the wedding if you said I could wear a costume,” another agreed. “Best wedding ever!”
Who doesn’t like surfing on the internet? However you have to realise
that surfing is not always anonymously. The Internet Service Providers
(ISP) keep the data from everyone that surfs on the internet. They know
how to get all kinds of personal information by controlling every step
you make on the internet. The ISP’s know what websites you visit, how
many hours you are active and from which location. They can then sell
this information to third parties. This results in a lot of money for
the ISP’s. It is at cost of your privacy. How can you make sure that you
can surf anonymously, without that the ISP knows what you are doing? In
this article we will give a few tips.
The incognito-mode
Lots of people think that there are fully anonymous on the internet when they use the incognito mode. If it is Google Chrome, Mozilla Firefox or Internet Explorer, every browser has the option to use the internet ‘invisible’. If you use this option the internet history of your browsers isn’t stored. The cookies aren’t stored either. When a different person uses your computer they can’t see what websites you have visited in the browser history. However, this incognito mode doesn’t give you full anonymity when surfing. The websites that are visited in the incognito mode are stored by the internet provider and the visited websites by you. They can always trace these websites back to you. This is done by using the Internet Protocol (IP) address.
The IP-address
The IP-address is some sort of post address of your router. When you visit a website, your IP address is sent and stored. With a IP address, websites can identify and locate you. So they know exactly where you live. With simple tools has the police for example traced many people thanks to the IP address. The incognito mode makes sure that other users from your computer can’t look into your browser history. However, it is not a solution for completely anonymous internet usage.
VPN-Connection vs. ISP
The only way to guarantee anonymity on the internet is by using a RitaVPN connection. With a VPN connection, your computer will make contact with a different, extern server. After that your internet traffic will go through this extern server. The rest of the worldwide web will think that you are using the internet from a different server. At this way, your IP address will remain out of sight. VPN download
www.fastexpressvpn.com/2019/08/26/ www.fastexpressvpn.com/2019/08/27/ www.fastexpressvpn.com/2019/08/28/
The incognito-mode
Lots of people think that there are fully anonymous on the internet when they use the incognito mode. If it is Google Chrome, Mozilla Firefox or Internet Explorer, every browser has the option to use the internet ‘invisible’. If you use this option the internet history of your browsers isn’t stored. The cookies aren’t stored either. When a different person uses your computer they can’t see what websites you have visited in the browser history. However, this incognito mode doesn’t give you full anonymity when surfing. The websites that are visited in the incognito mode are stored by the internet provider and the visited websites by you. They can always trace these websites back to you. This is done by using the Internet Protocol (IP) address.
The IP-address
The IP-address is some sort of post address of your router. When you visit a website, your IP address is sent and stored. With a IP address, websites can identify and locate you. So they know exactly where you live. With simple tools has the police for example traced many people thanks to the IP address. The incognito mode makes sure that other users from your computer can’t look into your browser history. However, it is not a solution for completely anonymous internet usage.
VPN-Connection vs. ISP
The only way to guarantee anonymity on the internet is by using a RitaVPN connection. With a VPN connection, your computer will make contact with a different, extern server. After that your internet traffic will go through this extern server. The rest of the worldwide web will think that you are using the internet from a different server. At this way, your IP address will remain out of sight. VPN download
www.fastexpressvpn.com/2019/08/26/ www.fastexpressvpn.com/2019/08/27/ www.fastexpressvpn.com/2019/08/28/
The society in the whole world can’t live without social media.
Providers, like Facebook, Facetime, LinkedIn, Instagram and Twitter are
the biggest providers from social media platforms. These providers want
their users to use the services safely from all over the world. Besides
that, companies can’t live without social media for the communication
and advertisement with their clients. Social media accounts can offer
the user acces at a easy and targeted way for a broader audience.
However, the social media life is not always sunshine and rainbows!
Hackers
Because of the fact that internet is more important in our society, and that the number of user from the internet are rising, the hacker activities are also increasing. For the hackers it is more interestring to create chaoas on the internet on purpose. Surprisingly it is not only the indivudals that suffer from this, but also the companies. Once cause for this is the bad security from internet user because of a bad password. Hackers have a easy time in logging it with these hacked passwords. There have been various leaks with Facebook, Flash, Paypal, Uber and WordPress
Dangers of the hacking of private data
On the internet, a lot is discussed and shared. Also the sharing of information is a important aspect with the users of different internet services. Lots of secrets can be shared by third parties. This was visible with The Fappening 2.0 when private videos e.g. Emma Watson, Amanda Seyfried and Laura Ponticorvo were spread through the internet. The Dutch Laura Ponticorvo was the first victim. In 2014 lots of mail accounts from famous stars were hacked and there photos were placed on the internet. To avoid hacking in the Netherlands, a VPN connection can be a solution.
Steal login data for identity theft
Identity fraud happens more often. A few thousand times a year a identity fraud is made. The government advised to the people to handle their private data and images with the greatest care. Too many times it happens that civilians are targeted by a identity fraud. The fraud is used for multiple purchases, taking out loans and spreading personal and privacy sensitive information. Safe internet is the first step in the fight against identity fraud.
Safe internet
The biggest concern from every internetuser is to get informed well on ways to use the internet in a safe way.The first rule to use the internet safely is the use of passwords. It is recommended to have a different password for every log in opportunity. This prevents unsafe situations on the internet. Without the right passwords, logging in on your accounts from Facebook, Facetime, Instagram, Pinterest and Twitter is impossible. A VPN connection can contribute to a safe online enviroment.
VPN connection
The solution to contribute to a more safe internettraffing is to use a VPN connection. A VPN is a Virtual Private Network that knows lots of applications. No only the IP address is hidden, it also gives you the opportunity to watch movies, series and streams safely from abroad. Also, the hackers cant trace inlogdata when there are internet activities made with a safe internet connection.VPN download
www.buyvpns.net/vpn-reviews/ www.buyvpns.net/vpn-tech/ www.buyvpns.net/live-streams/
Hackers
Because of the fact that internet is more important in our society, and that the number of user from the internet are rising, the hacker activities are also increasing. For the hackers it is more interestring to create chaoas on the internet on purpose. Surprisingly it is not only the indivudals that suffer from this, but also the companies. Once cause for this is the bad security from internet user because of a bad password. Hackers have a easy time in logging it with these hacked passwords. There have been various leaks with Facebook, Flash, Paypal, Uber and WordPress
Dangers of the hacking of private data
On the internet, a lot is discussed and shared. Also the sharing of information is a important aspect with the users of different internet services. Lots of secrets can be shared by third parties. This was visible with The Fappening 2.0 when private videos e.g. Emma Watson, Amanda Seyfried and Laura Ponticorvo were spread through the internet. The Dutch Laura Ponticorvo was the first victim. In 2014 lots of mail accounts from famous stars were hacked and there photos were placed on the internet. To avoid hacking in the Netherlands, a VPN connection can be a solution.
Steal login data for identity theft
Identity fraud happens more often. A few thousand times a year a identity fraud is made. The government advised to the people to handle their private data and images with the greatest care. Too many times it happens that civilians are targeted by a identity fraud. The fraud is used for multiple purchases, taking out loans and spreading personal and privacy sensitive information. Safe internet is the first step in the fight against identity fraud.
Safe internet
The biggest concern from every internetuser is to get informed well on ways to use the internet in a safe way.The first rule to use the internet safely is the use of passwords. It is recommended to have a different password for every log in opportunity. This prevents unsafe situations on the internet. Without the right passwords, logging in on your accounts from Facebook, Facetime, Instagram, Pinterest and Twitter is impossible. A VPN connection can contribute to a safe online enviroment.
VPN connection
The solution to contribute to a more safe internettraffing is to use a VPN connection. A VPN is a Virtual Private Network that knows lots of applications. No only the IP address is hidden, it also gives you the opportunity to watch movies, series and streams safely from abroad. Also, the hackers cant trace inlogdata when there are internet activities made with a safe internet connection.VPN download
www.buyvpns.net/vpn-reviews/ www.buyvpns.net/vpn-tech/ www.buyvpns.net/live-streams/