People are drinking collagen powder Do a quick scroll through Instagram, and chances are you’ll see a slew of wellness and fitness personalities touting the benefits of collagen peptide powder and adding it to their smoothies.Antiaging Powder So what exactly is collagen and why are some people clamoring for it?“Collagen is a structural protein made up of amino acids that's found naturally in the connective tissue of our bodies, such as our skin, hair, muscles, bones and even blood vessels,” Keri Gans, registered dietitian nutritionist and author of The Small Change Diet, tells Yahoo Lifestyle. “It is essentially the ‘glue’ that holds our body together, enables us to move and find stability.” Adds Joshua Zeichner, MD, director of cosmetic and clinical research in Mount Sinai Hospital’s department of dermatology, “Collagen is the main protein in our skin that provides structure and support.”And it’s that structure and support that plays a role in keeping skin looking smooth, firm, and wrinkle-free. But collagen production slows down as we age, which is why many people are turning to consuming collagen peptides (also known as hydrolyzed collagen) in the hopes that the supplements will reverse or at least stave off skin aging. “The hope for ingestible collagen is that it helps strengthen our skin to improve the appearance of fine lines and wrinkles, as well as enhance skin texture,” Zeichner tells Yahoo Lifestyle. But does consuming collagen powder actually do anything? Possibly.“The true benefit of ingestible collagen is unclear,” says Zeichner. “Since collagen is a large molecule, it is broken down by our gut into smaller pieces. The smaller pieces and individual amino acids may serve as building blocks for new collagen production. I look at ingestible collagen similar to the way I look at eating a high-protein meal.” Adds Gans: “Many individuals believe the numerous health claims in regards to collagen. There are claims that it can reduce constipation, improve gut health, improve sleep, decrease anxiety, reduce joint pain, eliminate food cravings and has anti-aging properties.” What are the benefits? Although more research is needed, there are some studies that have looked into collagen supplements’ potential benefits — particularly for easing joint pain. “Some preliminary research suggests collagen supplements may help reduce knee pain among people with osteoarthritis, and help reduce joint deterioration in athletes,” says Gans. While it’s no fountain of youth, there is some good news for people who are consuming collagen hoping to improve their skin and hair. “One small study revealed collagen supplements improved skin elasticity, but didn't do any more than a placebo to improve skin moisture and evaporation,” says Gans. A 2019 review of several studies showed that collagen supplements increase skin elasticity and hydration. It may also help with brittle, fragile nails. A small 2017 study in the Journal of Cosmetic Dermatology found that consuming collagen peptides daily for 24 weeks helped prevent nail breakage, increase nail growth, and improved the appearance of brittle nails. How safe is it? Collagen supplements are considered safe for the most part — as Zeichner puts it: “The only harm is to your pocketbook, as many of the collagen powders are pricey.” However, it’s important to read up on the source of the supplement’s main ingredient. The collagen found in supplements is typically sourced from cow (bovine) hides, as well as chicken cartilage, but in some cases they can be made from fish or eggs, which can be dangerous for people with those food allergies. “As with any supplement, one should read the label closely to make sure it doesn’t include any allergens that they are sensitive to,” suggests Gans. “Also, if on any medications a person should discuss with their doctor or a registered dietitian before implementing in their daily diet.” If you’re interested in trying collagen peptides powder, your best bet is to stick with a well-known brand, such as Vital Proteins. As Gans points out: “Like all supplements, collagen is not closely regulated by the Food and Drug Administration — therefore, one should choose nationally-recognized brands or store brands from a retailer they trust. Consumers can also look for a seal from a third-party certifier, such as NSF International, UL or USP.” You may also want to start with unflavored collagen peptide powder, which you can add to smoothies, as well as hot and cold beverages like coffee, without altering the flavor.
Glutathione Powder Antiaging Glutathione (GSH) is an important antioxidant in plants, animals, fungi and some bacteria and archaea. Glutathione prevents damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides and heavy metals. It is a tripeptide having a gamma peptide bond between the carboxyl group of glutamic acid side chain and the amine group of cysteine, and the carboxyl group of cysteine is linked to glycine through a normal peptide bond.L(+)-Arginine The thiol group is a reducing agent and is present in animal cells at a concentration of about 5 mM. Glutathione reduces disulfide bonds formed in the cytoplasm to cysteines by acting as electron donors. In this process, glutathione is converted to its oxidized form, glutathione disulfide (GSSG), also known as L - (-) - glutathione. Once oxidized, glutathione can be reduced by glutathione reductase, using NADPH as the electron donor. The ratio of reduced intracellular glutathione to oxidized glutathione is commonly used as a measure of cellular oxidative stress. Functions and Usages Glutathione exists in both reduced (GSH) and oxidized (GSSG) states. In the reduced state, the sulfhydryl group of cysteine is capable of providing reducing equivalents (H ++ e-) to other molecules, such as reactive oxygen species to neutralize them, or to maintain their reduced form for the protein cysteine. By donating electrons, glutathione itself becomes reactive and easily reacts with another active glutathione to form glutathione disulfide (GSSG). This reaction is most likely due to the relatively high concentration of glutathione in cells (up to 7 mM in the liver). In general, the interaction between GSH and other molecules with higher relative electrophilicity depletes intracellular GSH levels. An exception to this situation relates to the sensitivity of GSH to the relative concentration of electrophilic compounds. At high concentrations, the organic molecule diethyl maleate completely depletes the GSH levels in the cells. However, at low concentrations, cellular GSH levels decreased slightly and then tripled. GSH can be regenerated from GSSG by glutathione reductase (GSR): NADPH decreases the FAD present in GSR to produce transient FADH anions. This anion then rapidly disrupts the disulfide bond (Cys58-Cys63) and causes Cys63 to nucleophilic attack the nearest sulfide unit in the GSSG molecule (promoted by His467), resulting in a mixed disulfide bond (GS-Cys58) and GS- anion . His467 of GSR then protons the GS- anion to form the first GSH. Next, Cys63 nucleophile attacks the sulfide of Cys58, releasing the GS-anion, which in turn extracts solvent protons and releases it from the enzyme, resulting in a second GSH. Thus, for each GSSG and NADPH, two reduced GSH molecules are obtained that can again act as antioxidants to scavenge reactive oxygen species in the cells. In healthy cells and tissues, more than 90% of the total glutathione pool is reduced (GSH) and less than 10% exists as disulfide (GSSG). Increased GSSG to GSH ratio is considered an indicator of oxidative stress.
New Sarms ACP105 Raw Powder Muscle Building ACP-105 Product Name:ACP-105 CAS NO.:899821-23-9 Molecular Formula:C12H19ClN2O Purity:99% Appearance:White Powder Grade:Pharmaceutical Grade Description: ACP-105 can be taken orally and may be an effective SARM ACP-105, a novel non-steroidal SARM. ACP-105 is shown to be as potent and efficacious as testosterone in in vitro assays without interaction at other hormone receptors. In addition, ACP-105 demonstrates potent anabolic effects on muscle and bone with minimal effect on prostrate in preclinical models.Best Sarms Powder ACP-105 is a non-steroidal and selective androgen receptor agonist. ACP-105 is part of a class of molecules referred to as selective androgen receptor modulators (SARMs). SARMs may advance the standard of treatment for a variety of disorders including muscle-wasting conditions and osteoporosis, with fewer side effects as compared to current treatments based on testosterone replacement. ACP-105 has exhibited promising pharmacological properties and a favorable safety profile in preclinical testing.
Nootropics Ropinirole Hydrochloride Pharmaceutical powder for Parkinson′s Disease Product Name: 4-(2-Di-n-propylaminoethyl)-1,3-dichloro-2H-indol-2-one hydrochloride CAS: 91374-20-8 Standard: Enterprise Standard Natural / synthetic: synthetic Level: Pharmaceutical grade Content: 99% Appearance: white crystal Packing: 25KG/ cardboard drum Area: Early idiopathic Parkinson's disease Deferred product: Parkinson's drug Application: Acting on postsynaptic receptors in the striatum, compensating for the deficiency of dopamine, and compensating for increased sympathetic tone. Ropinirole can also be used for adjuvant treatment of patients who have already had switching problems. It can directly act on synaptic receptors, and it can produce continuous stimulation, thus alleviating the movement fluctuation of L-dopa, reducing its movement difficulty and reducing the dosage.Best Nootropics powder Nootropics Ropinirole Hydrochloride Pharmaceutical powder for Parkinson's Disease Description: Ropinirole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease. Ropinirole is used to treat symptoms of Parkinson's disease (stiffness, tremors, muscle spasms, and poor muscle control). Ropinirole is also used to treat restless legs syndrome (RLS). Only immediate-release ropinirole (Requip) is approved to treat either Parkinson symptoms or RLS. Extended-release ropinirole (Requip XL) is approved only to treat Parkinson symptoms. Parkinson's and RLS are two separate disorders. Having one of these conditions will not cause you to have the other condition.Nootropics Ropinirole Hydrochloride Pharmaceutical powder for Parkinson's Disease Dosage: The recommended starting dose for Parkinson's disease is 0.25 mg three times daily. Based on individual patient therapeutic response and tolerability, if necessary, the dose should then be titrated with weekly increments as described in Table 1. After Week 4, if necessary, the daily dose may be increased by 1.5 mg/day on a weekly basis up to a dose of 9 mg/day, and then by up to 3 mg/day weekly up to a maximum recommended total daily dose of 24 mg/day (8 mg three times daily). Doses greater than 24 mg/day have not been tested in clinical trials.
Smart Nootropics Alpha GPC CAS 28319-77-9 for Memory Improve L-Alpha Glycerylphosphorylcholine (Alpha GPC, choline alfoscerate) 28319-77-9 is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and is used as a nootropic dietary supplement to enhance memory and cognition.nootropics What's the other name of Alpha GPC CAS 28319-77-9 ? Alpha -GPC, Alpha Glycerol Phosphoryl Choline, Alpha-Glyceryl Phosphoryl Choline, Alpha-Glyceryl Phosphatidylcholine, Alpha-glycerylphosphorylcholine, Choline alphoscerate, Glycerophosphorylcholine, GPC, GroPCho, L-A-Glyceryl Phosphorylcholine, L-alpha-glycerylphosphorylcholine How does Alpha GPC CAS 28319-77-9 work?
Nutrition Smart Drugs Nootropics Raw Powder Aniracetam for Boosting Brain What is Aniracetam? Aniracetam is a popular choice among nootropic users for its ability to enhance cognition while reducing anxiety and boosting mood. It's also moderately priced and has little to no reported side effects when taken at recommended dosages. Aniracetam is chemically classed as a racetam (a drug that shares a pyrrolidone nucleus), and like most racetams, it works to a large extent by modulating neurotransmitters. The majority of people that have taken aniracetam report that its anxiolytic and mood enhancing effects are notable. Users report an increase in social confidence and improved verbal fluency. Despite aniracetam being fat soluble, which often indicates a slower breakdown with lasting effects, it only has a half-life of 1-3 hours, meaning it effects are short lived compared to some other nootropics. For this reason, it may be preferable to dose it 2-3 times a day, as necessary. Aniracetam's well-documented positive mood and anti-anxiety properties, combined with powerful cognitive enhancements and a demonstrated lack of side effects, make it one of the most popular nootropics on the market. While some users report an initial feeling of mental fogginess, the effect is usually temporary and within a day or two aniracetam's true nootropic nature starts to have a noticeable effect. In addition to generally elevating mood and lessening anxiety, aniracetam can enhance creativity while improving verbal fluency, comprehension, and memory retention. Users have reported a distinct feeling of calm and relaxation along with increased learning capacity, greater social ease and fluency, and better focus and attention to mental tasks over longer periods. There are also some reports that visuals may seem enhanced by aniracetam, appearing deeper and more vivid. While immediate acute benefits are anecdotally reported, studies involving individuals with senile cognitive disorders demonstrated significant improvements over placebo at 4 and 6 months. Aniracetam is fat soluble and is metabolized in the liver. Though it is fast acting, crossing the blood-brain barrier in as little as 30 minutes, it has a relatively brief half-life of just one to three hours so multiple doses over a period of hours may be needed to maintain effects.
99% Purity Aniracetam Nootropic Powder Aniracetam (Draganon, Sarpul, Ampamet, Memodrin, Referan), also known as N-anisoyl-2-pyrrolidinone, is an ampakine nootropic of the racetam chemical class purported to be considerably more potent than piracetam. It is lipid-soluble and has possible cognition-enhancing effects. It has been tested in animals extensively, Alzheimer's patients, and temporarily impaired healthy subjects. Racetam Aniracetam Benefits As stated above, Aniracetam can have many off-label uses. It is considered a fairly safe and low toxicity substance to improve cognition and memory or reduce anxiety symptoms. Like other racetams, it can have an added benefit of reducing free radicals and oxidative stress in the brain which can lead to degenerative diseases and neurological complications. It should not be used as a main line of defence or treatment for degenerative diseases like Alzheimer's and Dementia but may have merit in reducing some of the symptoms associated. Below, are some of the common observed benefits of Aniracetam. Results may vary. Improved Memory Increased Learning Ability Improved Cognitive Processing Heightened Reflexes Heightened Perception Reduced Anxiety Reduced Depression Aniracetam Dosage Doses between 10 mg/kg bodyweight and 100 mg/kg bodyweight have been used in rats with efficacy in laboratory settings. Limited human evidence finds that oral doses in the 1,000-1,500 mg range (over the course of a day) tend to be effective.Doses as low as 400 mg have been reported to have some efficacy, and it is common to take the above 1,000-1,500 mg aniracetam in two divided doses of 500-750 mg twice daily with meals.Aniracetam powder has a highly bitter taste, so capsules may be a better purchase for those who wish to avoid that.