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Oral semaglutide compared to Januvia in patients with type 2 diabetes


Oral Semaglutide powder 7 mg and 14 mg demonstrated superior HbA1c and body weight reductions compared to Januvia (sitagliptin 100 mg) . Non-inferiority for oral semaglutide 3 mg for HbA1c reductions at 26 weeks was not confirmed. Presented at the Endocrine Society Annual Meeting in New Orleans, Louisiana, with simultaneous publication in the Journal of the American Medical Association (JAMA).

PIONEER 3 was a phase IIIa trial investigating the efficacy and long-term safety of oral semaglutide 3 mg, 7 mg and 14 mg compared with sitagliptin 100 mg in adults with type 2 diabetes inadequately controlled with metformin, with or without sulfonylurea, over 78 weeks. Oral semaglutide is an investigational once-daily glucagon-like peptide-1 (GLP-1) analogue in a pill.

In PIONEER 3 , the primary endpoints of HbA1c and confirmatory secondary endpoint of change in body weight were assessed after 26 weeks of treatment. When applying the primary statistical approach, oral semaglutide 7 mg and 14 mg demonstrated superior HbA1c reductions of 1.0% and 1.3% at 26 weeks, compared to a 0.8% reduction with sitagliptin (both p
buzai232 Oct 6 '19, 04:13AM
High Purity 99.8% Peptide Hormone Tesamorelin



Tesamorelin powder is a synthetic peptide consisting of all 44 amino acids of hGRF with the addition of a trans-3-Hexenoic acid group.

Tesamorelin (also known as Egrifta) is a synthetic form which is used in the treatment of HIV-associated lipodystrophy.

Tesamorelin has been shown to reduce lipodystrophy in HIV-infected individuals. Lipodystrophy is a condition that causes changes in placement of body fat, including wasting and fat accumulation, and changes in metabolism.

Some side effects of Tesamorelin include nausea, night sweats, stomach upset, trouble sleeping, and vomiting. But serious side effects such as any allergic reactions are advised to call 911 due to a medical emergency.

Blood sugar is a problem in Tesamorelin that has been noted in small term tests, but long term use of Tesamorelin have been shown that blood sugar can bring itself back to normal. High blood sugar on Tesamorelin may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these problems occur, you should go to a doctor. If you are diabetic and are taking Tesamorelin, make sure you monitor your blood sugar closely.

Pregnant or breastfeeding women should not use Tesamorelin. If a woman is HIV positive, she should avoid breastfeeding her baby to lower exposure. Tesamorelin is not safe to use during pre and post-natal times for women.
buzai232 Oct 6 '19, 04:06AM
Wholesale Price of Tesamorelin Powder Provide Sample Packing for Test


Tesamorelin powder has been shown to reduce lipodystrophy in HIV-infected individuals. Lipodystrophy is a condition that causes changes in placement of body fat, including wasting and fat accumulation, and changes in metabolism. Similar to Tesamorelin is Sermorelin, which may be taken with GHRP-6 is clinical trials, that also promotes production and possible fat loss. Individuals with lipodystrophy may develop excess fat most notably around the liver, stomach, and other abdominal organs (visceral body fat).
Tesamorelin, (formerly known as TH9507), is a type of peptide called a hormone-releasing factor (GHRF). GHRF causes hormone to be created and spread in the body, which helps increase metabolism, reduce belly fat, improve body shape, and use of energy. Tesamorelin (formerly known as TH9507) is a synthetic grow hormone-releasing factor that stimulates the pituitary gland in the brain to secrete hormone; this indirect approach appears to maintain more stable, natural levels, like CJC-1295 DAC,. Clinical trials have shown that tesamorelin significantly reduces abdominal fat with fewer side effects than human grow hormone itself, although abdominal fat may return after the Tesamorlein is discontinued (depending upon the individual). Tesamorelin has been shown to reduce lipodystrophy in HIV-infected individuals as well as similarly reducing abdominal fat in NON-HIV-Infected individuals.
Tesamorelin Description:

Tesamorelin is a synthetic peptide consisting of all 44 amino acids of hGRF with the addition of a trans-3-Hexenoic acid group.Tesamorelin (also known as Egrifta) is a synthetic form of growth-hormone-releasing hormone which is used in the treatment of HIV-associated lipodystrophy.tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered. In conclusion, BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway.

Tesamorelin Applications:

1. Triptorelin raises test levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH).

2. Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty,estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.
buzai232 Oct 6 '19, 03:58AM
High Quality Bulk Price Gonadorelin Acetate Powder for Bodybuilding



What is gonadorelin acetate ?
Gonadorelin Acetate powder is a medicine that is the same as gonadotropin-releasing hypothalamus gland. GnRH causes the pituitary gland to release LH and FSH. LH and FSH control development in children and fertility in adults.
Gonadorelin acetate is used to test how well the hypothalamus and the pituitary glands are working.
Gonadorelin acetate is also used to cause ovulation ( release of an egg from the ovary ) in women who do not
have regular ovulation and menstrual periods because the hypothalamus gland does not release enough GnRH.
Function of gonadorelin acetate
1. Gonadorelin acetate is able to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly.
2. Gonadorelin acetate also alters metabolism of body fat and so may have application in the treatment of obesity.
3. Gonadorelin acetate is a drug which acts as a potent, orally active growth secretagogue.
HOW TO USE of gonadorelin acetate ?
Give onesubcutaneous each week for six consecutive weeks. There after use oneper month. It's best to give 6 days before intense work.

We recommend giving the shot the day after intense work then giving the shot every seven day there after. You must make sure to hydrate very well when using this product. Give normal vitamins and minerals to support normal racing function.
How to use gonadorelin acetate ?

Give onesubcutaneous each week for six consecutive weeks. There after use oneper month. It's best to give 6 days before intense work.We recommend giving the shot the day after intense work then giving the shot every seven day there after.
You must make sure to hydrate very well when using this product. Give normal vitamins and minerals to support normal racing function.
buzai232 Oct 6 '19, 03:08AM
NBA 2K20 Review: Doncic and Porzingis make the Mavs fun again

The Dallas Mavericks officially begin the 2019-2020 regular season in a little less than three weeks from now, meaning that the fan base will finally get to watch Luka Doncic and Kristaps Porzingis begin their push for the playoffs. Mavs training camp is underway as we speak (our guys Mike Fisher and Matt Galatzan give a review of Day 1 here), and preseason play is less than a week away. nba mt

In the meantime, though, fans can continue to build an idea of what this team might look like in live action by playing with the Mavs in NBA 2K20.As a big self-proclaimed fan of the 2K franchise, I can honestly say that this year's game is the most fun I've had playing with the Mavs in a long time. Doncic and Porzingis both having 87-overall ratings is a big reason why. For context, the Mavs highest rated player in last year's game was DeAndre Jordan, who was labeled with an 86-overall rating. That rating, as we found out through the 2018-2019 season, always seemed to be generous (Jordan now has an 81-overall rating in 2K20).

The chemistry that we're all hoping for and expect to see from Doncic and Porzingis this season already exists in the virtual 2K world. Both players' games mesh together perfectly, giving the Mavs a fighting chance against any other team in the game. Simply put, it's just easier to do cool things with Mavs this time around.

Is the rest of the roster not having a great game? That's okay, because Doncic and Porzingis are more than capable of shouldering the load in 2K20.Overall, 2K remains king when it comes to high-quality graphics and gameplay, despite not always being perfect. Believe it or not, there was a time when NBA Live was the go-to basketball video game, but those days are long gone. Until EA Sports decides to put the same amount of resources into NBA Live that it does for FIFA, 2K will continue to basically hold a monopoly in this field.www.nbamtcoin.com
buzai232 Oct 6 '19, 03:01AM
One of the top trending topics on Twitter right now is the #fix2k20 hashtag. This bubbled up over the weekend following the September 6 launch of NBA 2K20. Developer 2K’s servers are struggling to keep up with the huge influx of players, and that’s causing the basketball sim to break down.nba mt coins

Some NBA 2K players are encountering issues that seemingly stem from the troublesome servers. Many of these fans are reporting that it’s crashing after matches. And others are seeing NBA 2K20 delete (or, more likely, fail to save) their MyTeam rosters. Similar issues are also impacting progression. After matches, players are sometimes getting error messages or seeing that they earned zero points from their win.

I’ve asked 2K Games about these issues, and I’ll update this story with any new information from the company.Many of these issues are, unfortunately, standard for new online games. Scaling servers to meet demand is difficult, and a lot of popular games have to work through downtime and connection errors.

Most recently, releases like Gears of War 5 put a lot of stress on Xbox Live last weekend. And World of Warcraft Classic had huge queues when it launched last month.

Still, that doesn’t mean that 2K Games can ignore #fix2k20. NBA 2K20 has a heavy emphasis on microtransaction spending, and no one is going to spend extra money on the game if it’s not working correctly. So the publisher is leaving money on the table.

Getting NBA 2K20 up and running so that people feel good about spending money is probably enough motivation to patch up the servers. But if it’s not, getting #fix2K20 to No. 1 trending worldwide on Twitter might also do the trick.visit homepage
buzai232 Oct 6 '19, 02:55AM
NBA 2K20 1.05 Patch Notes: MyTEAM, Bug Fixes & More


Another sizable patch is hitting NBA 2K20 with update 1.05 and players will have to wait until it’s finished before hopping back into the action.

The September 30 patch is the size of a full-length game, coming in at 20.599 GB on PS4, and it’s not the first time this has happened either. NBA 2K20 was heavily criticized upon release for its plethora of bugs but 2K has been hard at work ironing those out.buy mt 2k20

Today’s update came with a set of patch notes, which isn’t always guaranteed when an update hits so at least we have an idea of some of the things that were fixed.Patch notes and the 2K series don’t usually go together so it’s nice to see a set of notes when an update does come out so players can at least get some sort of idea of what was targeted.

Of course, the patch notes aren’t nearly as long as you’d expect them to be with an update so big so there’s probably more going on behind the scenes that we don’t know about.The information about this update was posted to the game’s Facebook page, so if you’re ever looking for patch notes, that’s where you’ll want to check.

Some problems with MyTEAM were addressed but the bulk of this update likely lies with the many bug fixes that the team said they tackled.With this being the only NBA game currently on the market, it’s leaving a lot to be desired but the team is slowly plugging away at all of the issues currently affecting the game.

You can take a look at the full list of patch notes below, but you probably won’t come away learning too much about the update.
Complete NBA 2K20 1.05 Patch Notes

Fixed an issue that caused some Play Now Online, MyTEAM Unlimited, Play With Friends, and All-Star Team-up games to disconnect prior to completion.
Fixed an issue where some MyTEAM users were reporting their Collector Level progress was shown as being reset (visit the Collector Level menu to return to your proper level).
Many, many more fixes included to improve the overall experience of NBA 2K20!see more
buzai232 Oct 6 '19, 02:48AM
Madden 20 Signature Series Revealed



A number of new content updates arrived for EA’s Madden 20 on Thursday, October 3. Each week, they unveil a pair of new Madden 20 Signature Series players. Two more were revealed on Thursday, as well as the news that Keenan Allen is the newest Superstar X-Factor player. He’ll be replacing a current NFL free agent who is not playing at the moment. Here are all of the details on Signature Series and Superstar X-Factor.buy nhl 20 coins

The Seattle Seahawks are in action in the NFL on Thursday night against the Los Angeles Rams. It’s only fitting that one of their players received a new Madden 20 Signature Series card. That’s none other than quarterback Russell Wilson who gets a sweet new 91 overall card. The 5-foot-11 QB gets a 93 Throw on the Run, 91 Play Action, 88 Throw Accuracy Deep, and 86 Throw Power amongst his key attributes on the card.

The other LTD Madden 20 Signature Series player is right end Jurrell Casey. The Tennessee Titans star has a 94 Awareness, 92 Tackling, and 90 Strength as his key attributes. Here’s a look at Russell Wilson and Casey’s new items:Both of these Madden 20 Signature Series player items are available for a limited time in packs. They’ll be there until Saturday, October 5, at 10 a.m. Eastern Time. Of course, they’ll be in the Auction area past then for those gamers who want to spend some Coins to get them.

Whenever a Superstar X-Factor player retires or is cut, then it appears EA will replace them with another player. That was the case when Andrew Luck retired as EA made T.Y. Hilton a new Superstar X-Factor player in the game. The idea was to keep it so there are 50 Superstar X-Factor players overall.

Wide receiver Antonio Brown isn’t playing due to being cut by the Patriots over a week ago. The former Pats WR was coming up still on a load screen showing him off as a Superstar X-Factor player. On Thursday, EA revealed that Brown has been replaced with Keenan Allen of the Chargers as a new Superstar X-Factor player.Allen is now the 50th player in the game who has a Superstar X-Factor ability. The Chargers’ wide receiver has the Rac’ Em Up ability which is where the player is able to win RAC catches versus single coverage. In addition, Allen has two abilities: In Out Elite and Slot-o-Matic.

EA took Antonio Brown off the Patriots’ roster and also out of their Madden 20 player ratings database. Right now, Keenan Allen ranks as the No. 5 wide receiver overall with a 94 rating. He trails Michael Thomas (Saints, 95), Odell Beckham Jr. (Browns, 97), Julio Jones (Falcons, 98), and DeAndre Hopkins (Texans, 99).Want to buy mut 19 coins from www.hutcoin.com
buzai232 Oct 6 '19, 02:41AM
Madden 20 MUT: Sammy Watkins, Lamar Jackson and more highlight TOTW 1


Following an exhilarating first week of the NFL season, we’ve got our first Team of the Week in Madden 20 Ultimate Team.

There were a few standout performances this past Sunday, but none more impressive than Baltimore Ravens quarterback Lamar Jackson. The second-year quarterback torched the Miami Dolphins for 324 yards and five touchdowns before leaving the game in the third quarter of the blowout. As a result of his performance, Jackson is this week’s Hero for Team of the Week with 90 Speed (more than Michael Vick).buy hut coins
Unfortunately, his Medium Throw Accuracy (82) and Deep Throw Accuracy (82) leave a lot to be desired in the passing game. Because of these low ratings, you’re probably better off sticking with Steve Young. Hopefully, you sold Michael Vick on the high back when he was first released because he’s gone down in value considerably.
This week’s Limited player is Sammy Watkins after his 3 touchdown performance (9 receptions, 198 yards). WIth 99 Vertical Threat, 96 Jump Ball, 98 Slot, 98 Possession, and 98 RAC, Watkins is essentially God-tier in Ultimate Team. Unfortunately, he will only be found in packs until Thursday, September 12 at 10:00 a.m. ET and he is not Power Up eligible, so you better get pulling.

New York Jets MLB C.J. Mosley is the Hero on defense after returning an interception for a touchdown and recovering a fumble in a losing effort against the Buffalo Bills on Sunday. Mosley actually exited the game due to a groin injury, but his performance was enough to earn him Team of the Week honors.fut coins online Buy Now
buzai232 Oct 6 '19, 02:26AM
'Madden NFL 20' releases surprise new gameplay mode Superstar KO


One month after release, "Madden NFL 20" has released a game-changing new mode — and at no extra cost.Superstar KO, which went live as part of a free update to the base game at 9 a.m. Tuesday, is a new spin on the tried-and-true "Madden" formula and a dramatic departure from its traditional simulation-focused experience. buy madden 20 coins

As the name suggests, designated superstar players drive this new online-only feature. Players select one of eight fictional teams, whose base personnel are built around specific strengths and weaknesses, with the potential for more to be added later on. Jake Stein, associate producer of "Madden NFL 20," told amNewYork last Wednesday at the Microsoft Store in midtown that the team at EA Sports is treating Superstar KO like a live service, with updates throughout the months to come to maintain balance between the teams or tweak the experience based on user feedback.

Playbooks are stripped down to 24 plays to simplify decision-making. Dot City, a team whose pass-centric offense, has just one running play available, while Shutdown is a defense-heavy team offers twice as many defensive plays from which to choose but only half the offensive options. "Think of it almost like a character select screen in a traditional fighting game," Stein said.

Upon choosing a team, players will then draft three superstar players to their roster in a similar manner to that of the MUT Draft mode — select one player out of four on offense or defense in each round. In addition to active stars such as Odell Beckham Jr. or Von Miller and legends including Jim Brown and Jerry Rice, celebrities DJ Khaled and Lil Yachty each has his own useful X-Factor ability to drive home how different Superstar KO is from the norm. Both hip-hop personalities serve as coaches for two of the teams. And, unlike the base gameplay, X-Factor power-ups are active constantly, rather than triggered by meeting in-game requirements.

Games aren't intended to last longer than 10 minutes real-time, with the emphasis being a quick and accessible experience. The structure of the game bears similarities to the NFL's overtime rule, but with each team being granted at least one possession. With no special teams plays, touchdowns and two-point conversions drive the scoring.

If the game remains tied, players enter a scenario dubbed "tug of war." In this tiebreaker, the ball is placed at the 50-yard line, and each team takes up to three turns back-and-forth to get the ball as close to the opposing end zone as possible. A touchdown automatically wins the game.Click to Buy more fut coins
buzai232 Oct 6 '19, 02:18AM
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