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DHB, also known as Dihydroboldenone/DHB powder supplier
or 1-Testosterone, has gotten a lot of hype in the past few years in
the bodybuilding community.Guys are always looking for the new exotic
steroid to try.It's almost like a form of shiny object syndrome.
Juice heads are looking for the next best thing, and as soon as a hormone they haven't tried starts getting some traction in the community, they jump on the bandwagon assuming that this new hormone must hold the key to unlocking their true bodybuilding potential.
The fact of the matter is that 1-Testosterone has been around for quite some time, however, it just was never seen as efficacious enough to pursue in a therapeutic context.
What Is DHB?
DHB is a synthetic androstane steroid and a derivative of dihydrotestosterone (DHT).It is more commonly known as the 5-alpha reduced metabolite of Boldenone (Equipoise).Just like how Testosterone interacts with 5-alpha reductase to produce dihydrotestosterone (DHT), Boldenone 5-alpha reduces into DHB (Dihydroboldenone).
Among many using this hormone in a performance enhancing context, it is reported to be formidable to Trenbolone in regards to muscle building potential, but with a more favorable side-effect profile.
Advocates of the dihydroboldenone claim that it is twice as strong as Testosterone.This claim is typically based on the premise that DHB features an anabolic to androgenic ratio of 200/100.Thus, it is implied to be twice as tissue selective as Testosterone, milligram for milligram.Unlike its parent hormone, DHB features no estrogenic effects, which is seen as a desirable trait among those seeking efficacious steroids to use in conjunction with Testosterone.
Boldenone (Equipoise) Vs DHB (Dihydroboldenone)
Boldenone (Equipoise) is a derivative of Testosterone that was created by adding a double-bond between carbon atoms one and two.This bond dramatically slows aromatization and makes the steroid a poor substrate for 5-alpha reductase.While Boldenone is a substrate for 5-alpha reductase and can be converted into DHB, the amount converted by even a high dose of Boldenone is not substantial.
Although Boldenone inherently has strong anabolic effects and moderate androgenic effects, DHB is perceived by many in the bodybuilding community as the superior hormone in a muscle building context.Mega-dosing EQ in order to try and achieve moderate serum concentrations of DHB is a strategy that has been deployed by many bodybuilders in the past.
Due to the parent hormone Equipoise being such a poor substrate for 5-alpha reductase, an increasing number of bodybuilders have started to simply opt to use straight DHB instead.
Juice heads are looking for the next best thing, and as soon as a hormone they haven't tried starts getting some traction in the community, they jump on the bandwagon assuming that this new hormone must hold the key to unlocking their true bodybuilding potential.
The fact of the matter is that 1-Testosterone has been around for quite some time, however, it just was never seen as efficacious enough to pursue in a therapeutic context.
What Is DHB?
DHB is a synthetic androstane steroid and a derivative of dihydrotestosterone (DHT).It is more commonly known as the 5-alpha reduced metabolite of Boldenone (Equipoise).Just like how Testosterone interacts with 5-alpha reductase to produce dihydrotestosterone (DHT), Boldenone 5-alpha reduces into DHB (Dihydroboldenone).
Among many using this hormone in a performance enhancing context, it is reported to be formidable to Trenbolone in regards to muscle building potential, but with a more favorable side-effect profile.
Advocates of the dihydroboldenone claim that it is twice as strong as Testosterone.This claim is typically based on the premise that DHB features an anabolic to androgenic ratio of 200/100.Thus, it is implied to be twice as tissue selective as Testosterone, milligram for milligram.Unlike its parent hormone, DHB features no estrogenic effects, which is seen as a desirable trait among those seeking efficacious steroids to use in conjunction with Testosterone.
Boldenone (Equipoise) Vs DHB (Dihydroboldenone)
Boldenone (Equipoise) is a derivative of Testosterone that was created by adding a double-bond between carbon atoms one and two.This bond dramatically slows aromatization and makes the steroid a poor substrate for 5-alpha reductase.While Boldenone is a substrate for 5-alpha reductase and can be converted into DHB, the amount converted by even a high dose of Boldenone is not substantial.
Although Boldenone inherently has strong anabolic effects and moderate androgenic effects, DHB is perceived by many in the bodybuilding community as the superior hormone in a muscle building context.Mega-dosing EQ in order to try and achieve moderate serum concentrations of DHB is a strategy that has been deployed by many bodybuilders in the past.
Due to the parent hormone Equipoise being such a poor substrate for 5-alpha reductase, an increasing number of bodybuilders have started to simply opt to use straight DHB instead.
China Lanreotide Peptide Powder (INN) for Neuroendocrine Tumors
Lanreotide powder (INN) is a medication used in the management of acromegaly and symptoms caused by neuroendocrine tumors, most notably carcinoid syndrome.
Lanreotide is used in the treatment of acromegaly, due to both pituitary and non-pituitary growth hormone-secreting tumors, and the management of symptoms caused by neuroendocrine tumors, particularly carcinoid tumors and VIPomas. In the United States and Canada, lanreotide is only indicated for the treatment of acromegaly. In the United Kingdom, it is also indicated in the treatment of thyrotrophic adenoma,a rare tumor of the pituitary gland which secretes TSH.
Lanreotide also shows activity against non-endocrine tumors, and, along with other somatostatin analogues, is being studied as a possible general antitumor agent.
Synonyms:LANREOTIDE;AUTOGEL;BETA-(2-NAPHTHYL)-D-ALA-CYS-TYR-D-TRP-LYS-VAL-C YS-THR AMIDE;BIM-23014;ANGIOPEPTIN;H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-THR-NH2;H-D -2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-THR-NH2, (DISULFIDE BOND);IPSTYL
CAS:108736-35-2
MF:C54H69N11O10S2
MW:1096.32
Product Categories:hormones
storage temp. :20°C
Chemical Properties:White to off-white lyophilised powder
Lanreotide Introduction:
Lanreotide (as lanreotide acetate) is manufactured by Ipsen, and marketed under the trade name Somatuline. It is available in several countries, including the United Kingdom, Australia and Canada, and was approved for sale in the United States by the Food and Drug Administration (FDA) on August 30, 2007.
Lanreotide Indications
Lanreotide is used in the treatment of acromegaly, due to both pituitary and non-pituitary growth hormone-secreting tumors, and the management of symptoms caused by neuroendocrine tumors, particularly carcinoid tumors and VIPomas. In the United States and Canada, lanreotide is only indicated for the treatment of acromegaly. In the United Kingdom, it is also indicated in the treatment of thyrotrophic adenoma, a rare tumor of the pituitary gland which secretes.
Lanreotide also shows activity against non-endocrine tumors, and, along with other somatostatin analogues, is being studied as a possible general antitumor agent.
Lanreotide ,In Dec 2014 the US FDA approved lanreotide for the treatment of patients with unresectable, well or moderately differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
Lanreotide powder (INN) is a medication used in the management of acromegaly and symptoms caused by neuroendocrine tumors, most notably carcinoid syndrome.
Lanreotide is used in the treatment of acromegaly, due to both pituitary and non-pituitary growth hormone-secreting tumors, and the management of symptoms caused by neuroendocrine tumors, particularly carcinoid tumors and VIPomas. In the United States and Canada, lanreotide is only indicated for the treatment of acromegaly. In the United Kingdom, it is also indicated in the treatment of thyrotrophic adenoma,a rare tumor of the pituitary gland which secretes TSH.
Lanreotide also shows activity against non-endocrine tumors, and, along with other somatostatin analogues, is being studied as a possible general antitumor agent.
Synonyms:LANREOTIDE;AUTOGEL;BETA-(2-NAPHTHYL)-D-ALA-CYS-TYR-D-TRP-LYS-VAL-C YS-THR AMIDE;BIM-23014;ANGIOPEPTIN;H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-THR-NH2;H-D -2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-THR-NH2, (DISULFIDE BOND);IPSTYL
CAS:108736-35-2
MF:C54H69N11O10S2
MW:1096.32
Product Categories:hormones
storage temp. :20°C
Chemical Properties:White to off-white lyophilised powder
Lanreotide Introduction:
Lanreotide (as lanreotide acetate) is manufactured by Ipsen, and marketed under the trade name Somatuline. It is available in several countries, including the United Kingdom, Australia and Canada, and was approved for sale in the United States by the Food and Drug Administration (FDA) on August 30, 2007.
Lanreotide Indications
Lanreotide is used in the treatment of acromegaly, due to both pituitary and non-pituitary growth hormone-secreting tumors, and the management of symptoms caused by neuroendocrine tumors, particularly carcinoid tumors and VIPomas. In the United States and Canada, lanreotide is only indicated for the treatment of acromegaly. In the United Kingdom, it is also indicated in the treatment of thyrotrophic adenoma, a rare tumor of the pituitary gland which secretes.
Lanreotide also shows activity against non-endocrine tumors, and, along with other somatostatin analogues, is being studied as a possible general antitumor agent.
Lanreotide ,In Dec 2014 the US FDA approved lanreotide for the treatment of patients with unresectable, well or moderately differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
Hot Selling 99.5% Purity and High Standard Ipamorelin Powder
Ipamorelin powder a fascinating new muscle building discovery that is getting a lot of attention in the bodybuilding world. Like the GHRP-6 peptide (releasing hexapeptide), it is a synthetic peptide that has powerful releasing properties. And these releasing properties are what is of interest to athletes and bodybuilders since they can make a tremendous difference in the amount of muscle you can grow and how quickly you burn fat.
Application:
Ipamorelin is an interesting peptide taken 300mcg twice daily or you could lower the dose for 3 times daily, side effects are head rushs, I would recommend taking this 30 minutes before workout ,with gear, Ipamorelin is a new and potent synthetic pentapeptide which has distinct .With the objective of investigating the effects on longitudinal bone growth rate , body weight , , Ipamorelin in different doses (0, 18, 90 and 450 μg/day) was injected three times daily for 15 days to test subjects, After intravital Tetracycline labelling on days 0, 6, and 13, LGR was determined by measuring the distance between the respective fluorescent bands in the proximal tibia metaphysis. Ipamorelin dose-dependently increased LGR from 42 μm/day in the vehicle group to 44, 50, and 52 μm/day in the treatment groups .
Ipamorelin powder a fascinating new muscle building discovery that is getting a lot of attention in the bodybuilding world. Like the GHRP-6 peptide (releasing hexapeptide), it is a synthetic peptide that has powerful releasing properties. And these releasing properties are what is of interest to athletes and bodybuilders since they can make a tremendous difference in the amount of muscle you can grow and how quickly you burn fat.
Application:
Ipamorelin is an interesting peptide taken 300mcg twice daily or you could lower the dose for 3 times daily, side effects are head rushs, I would recommend taking this 30 minutes before workout ,with gear, Ipamorelin is a new and potent synthetic pentapeptide which has distinct .With the objective of investigating the effects on longitudinal bone growth rate , body weight , , Ipamorelin in different doses (0, 18, 90 and 450 μg/day) was injected three times daily for 15 days to test subjects, After intravital Tetracycline labelling on days 0, 6, and 13, LGR was determined by measuring the distance between the respective fluorescent bands in the proximal tibia metaphysis. Ipamorelin dose-dependently increased LGR from 42 μm/day in the vehicle group to 44, 50, and 52 μm/day in the treatment groups .
White Lyophilized Powder n acetyl selank peptide 5mg 10mg 2mg selank
Selank powder, which was developed in Russia, is a short peptide with nootropic and anxiolytic properties. It is a synthetic analogue of naturally occurring Tuftsin, an immunomodulatory peptide that modulates IL-6, T helper cells, monoamine neurotransmitters, and brain-derived neurotropic factor (BDNF). In fact, Selank and Tuftsin are essentially the same except that Selank has an additional four amino acids in its chain that help to improve metabolic stability and half-life.
Selank has been tested in clinical trials as a potential treatment for generalized anxiety disorder.
Selank Anxiety Effects Based on Genes Related to GABA Neurotransmitter
According to Dr. Anastasiya Volkova of the Institute of Molecular Genetics in Russia, “numerous clinical studies have shown that Selank has strong antianxiety and neuroprotective effects in the treatment of anxiety. The clinical effects of Selank are similar to those of the classical antianxiety medications such as benzodiazepine, which are allosteric modulators of GABAA receptors and increase the inhibitory action of GABA.” Selank’s effects include reducing anxiety, improving mood, lower stress levels, and positively influencing memory and learning. Like benzodiazepines, low doses of Selank have a sedating effect. Unlike benzodiazepines, Selank does not appear to be habit-forming and does not lead to symptoms of withdrawal or amnesia.
Research in rats shows that of the 84 genes known to be connected to GABA signaling in some way, seven are heavily modulated by Selank and 45 show some change in expression when the peptide is administered. Overall, 52 genes related to GABA signaling are affected by Selank to some degree. These results indicate that Selank can directly influence the expression of genes in nerve cells and that it likely produces effects by changing the affinity of the GABA receptor for GABA[1].
This alteration of receptor affinity likely explains why Selank is synergistic with benzodiazepines and other GABA receptor agonists.
Selank and the Immune System in Anxiety
Research in patients with depression indicates that Selank can suppress the gene responsible for the production of the inflammatory cytokine IL-6. Interestingly, this effect is only seen in patients with depression and does not appear to take place in healthy individuals[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression.
When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins.
Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops.
Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation[8].This alteration of receptor affinity likely explains why Selank is synergistic with benzodiazepines and other GABA receptor agonists.
Selank and the Immune System in Anxiety
Research in patients with depression indicates that Selank can suppress the gene responsible for the production of the inflammatory cytokine IL-6. Interestingly, this effect is only seen in patients with depression and does not appear to take place in healthy individuals[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression.
When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins.
Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops.
Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation[8].
Selank powder, which was developed in Russia, is a short peptide with nootropic and anxiolytic properties. It is a synthetic analogue of naturally occurring Tuftsin, an immunomodulatory peptide that modulates IL-6, T helper cells, monoamine neurotransmitters, and brain-derived neurotropic factor (BDNF). In fact, Selank and Tuftsin are essentially the same except that Selank has an additional four amino acids in its chain that help to improve metabolic stability and half-life.
Selank has been tested in clinical trials as a potential treatment for generalized anxiety disorder.
Selank Anxiety Effects Based on Genes Related to GABA Neurotransmitter
According to Dr. Anastasiya Volkova of the Institute of Molecular Genetics in Russia, “numerous clinical studies have shown that Selank has strong antianxiety and neuroprotective effects in the treatment of anxiety. The clinical effects of Selank are similar to those of the classical antianxiety medications such as benzodiazepine, which are allosteric modulators of GABAA receptors and increase the inhibitory action of GABA.” Selank’s effects include reducing anxiety, improving mood, lower stress levels, and positively influencing memory and learning. Like benzodiazepines, low doses of Selank have a sedating effect. Unlike benzodiazepines, Selank does not appear to be habit-forming and does not lead to symptoms of withdrawal or amnesia.
Research in rats shows that of the 84 genes known to be connected to GABA signaling in some way, seven are heavily modulated by Selank and 45 show some change in expression when the peptide is administered. Overall, 52 genes related to GABA signaling are affected by Selank to some degree. These results indicate that Selank can directly influence the expression of genes in nerve cells and that it likely produces effects by changing the affinity of the GABA receptor for GABA[1].
This alteration of receptor affinity likely explains why Selank is synergistic with benzodiazepines and other GABA receptor agonists.
Selank and the Immune System in Anxiety
Research in patients with depression indicates that Selank can suppress the gene responsible for the production of the inflammatory cytokine IL-6. Interestingly, this effect is only seen in patients with depression and does not appear to take place in healthy individuals[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression.
When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins.
Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops.
Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation[8].This alteration of receptor affinity likely explains why Selank is synergistic with benzodiazepines and other GABA receptor agonists.
Selank and the Immune System in Anxiety
Research in patients with depression indicates that Selank can suppress the gene responsible for the production of the inflammatory cytokine IL-6. Interestingly, this effect is only seen in patients with depression and does not appear to take place in healthy individuals[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression.
When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins.
Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops.
Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation[8].
Octreotide Market Opportunities, Top Vedors, Industry Survey, Capital Investment and Trend Report By 2024
Octreotide Acetate powder, Octreotide powder Market Report 2019 to 2024” is the definitive study of the global Octreotide market. The content includes orientation technology, industry drivers, geographic trends, market statistics, market forecasts, producers, and equipment suppliers.
The report firstly introduced the Octreotide basics: definitions, classifications, applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on. Then it analyzed the world’s main region market conditions, including the product price, profit, capacity, production, supply, demand and market growth rate and forecast etc. In the end, the report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.
The production of Octreotide mainly focuses on Europe, China and India. The Europe occupies the largest share and it about reach 66.36% in 2015. Novartis exports to other countries mainly in the form of finished drug.
The Octreotide product increased fast in the past five years, the production growth in the past two years. There have been new manufacturers to enter the field year by year. But for now , it is difficult to obtain certification.
It will expect that the production and the capacity will increase fast in the future, But with octreotide acetate in China continues to mature in manufacturing technology, in the future, trade of octreotide API will gradually decrease, more and more Octreotide will sold as finished medicine.
The worldwide market for Octreotide is expected to grow at a CAGR of roughly xx% over the next five years, will reach xx million US$ in 2024, from xx million US$ in 2019, according to a new GIR (Global Info Research) study.
This report focuses on the Octreotide in global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. This report categorizes the market based on manufacturers, regions, type and application.
The overviews, SWOT analysis and strategies of each vendor in the Octreotide market provide understanding about the market forces and how those can be exploited to create future opportunities.
Octreotide Acetate powder, Octreotide powder Market Report 2019 to 2024” is the definitive study of the global Octreotide market. The content includes orientation technology, industry drivers, geographic trends, market statistics, market forecasts, producers, and equipment suppliers.
The report firstly introduced the Octreotide basics: definitions, classifications, applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on. Then it analyzed the world’s main region market conditions, including the product price, profit, capacity, production, supply, demand and market growth rate and forecast etc. In the end, the report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.
The production of Octreotide mainly focuses on Europe, China and India. The Europe occupies the largest share and it about reach 66.36% in 2015. Novartis exports to other countries mainly in the form of finished drug.
The Octreotide product increased fast in the past five years, the production growth in the past two years. There have been new manufacturers to enter the field year by year. But for now , it is difficult to obtain certification.
It will expect that the production and the capacity will increase fast in the future, But with octreotide acetate in China continues to mature in manufacturing technology, in the future, trade of octreotide API will gradually decrease, more and more Octreotide will sold as finished medicine.
The worldwide market for Octreotide is expected to grow at a CAGR of roughly xx% over the next five years, will reach xx million US$ in 2024, from xx million US$ in 2019, according to a new GIR (Global Info Research) study.
This report focuses on the Octreotide in global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. This report categorizes the market based on manufacturers, regions, type and application.
The overviews, SWOT analysis and strategies of each vendor in the Octreotide market provide understanding about the market forces and how those can be exploited to create future opportunities.
Best Quality Peptide Octreotide CAS: 83150-76-9
Octreotide Acetate powder, Octreotide powder
has also been used off-label for the treatment of severe, refractory
diarrhea from other causes. It is used in toxicology for the treatment
of prolonged recurrent hypoglycemia after sulfonylurea and possibly
meglitinides overdose. It has also been used with varying degrees of
success in infants with nesidioblastosis to help decrease insulin
hypersecretion.
Octreotide has been used experimentally to treat obesity,
particularly obesity caused by lesions in the hunger and satiety centers
of the hypothalamus, a region of the brain central to the regulation of
food intake and energy expenditure. The circuit begins with an area of
the hypothalamus, the arcuate nucleus, that has outputs to the lateral
hypothalamus and ventromedial hypothalamus (VMH), the brain's feeding
and satiety centers, respectively.The VMH is sometimes injured by
ongoing treatment for acute lymphoblastic leukemia (ALL) or surgery or
radiation to treat posterior cranial fossa tumors.
APPLICATION
1.Octreotide has also been used off-label for the treatment of
severe, refractory diarrhea from other causes. It is used in toxicology
for the treatment of prolonged recurrent hypoglycemia after sulfonylurea
and possibly meglitinides overdose. It has also been used with varying
degrees of success in infants with nesidioblastosis to help decrease
insulin hypersecretion.
2.Octreotide has been used experimentally to treat obesity,
particularly obesity caused by lesions in the hunger and satiety centers
of the hypothalamus, a region of the brain central to the regulation of
food intake and energy expenditure.[4] The circuit begins with an area
of the hypothalamus, the arcuate nucleus, that has outputs to the
lateral hypothalamus (LH) and ventromedial hypothalamus (VMH), the
brain's feeding and satiety centers, respectively.[5][6] The VMH is
sometimes injured by ongoing treatment for acute lymphoblastic leukemia
(ALL) or surgery or radiation to treat posterior cranial fossa tumors.
What is octreotide?
Octreotide powder is a man-made protein that is similar to a hormone in the body called somatostatin. Octreotide lowers many substances in the body such as insulin and glucagon (involved in regulating blood sugar), and chemicals that affect digestion.
Octreotide is used to treat acromegaly. Octreotide is also used to reduce flushing episodes and watery diarrhea caused by cancerous tumors (carcinoid syndrome) or tumors called vasoactive intestinal peptide tumors (VIP adenomas).
Octreotide may also be used for purposes not listed in this medication guide.
What is the most important information I should know about octreotide?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
SLIDESHOW
Always Hungry? You Just Might Have One Of These Conditions
What should I discuss with my healthcare provider before using octreotide?
You should not use octreotide if you are allergic to it.
To make sure you can safely use octreotide, tell your doctor if you have any of these other conditions:
diabetes;
gallbladder disease;
heart disease, high blood pressure, or heart rhythm disorder;
thyroid problems;
pancreatitis;
liver disease; or
kidney disease (or if you are on dialysis).
Octreotide is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Using octreotide can affect certain hormones that may make it easier for you to get pregnant, even if you were unable to get pregnant before. Talk to your doctor about using birth control to avoid unwanted pregnancy.
It is not known whether octreotide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I use octreotide?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Octreotide is injected under the skin, or into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine. Be sure to follow the instructions for the exact type of octreotide your doctor has prescribed for you.
Store octreotide in the original carton in the refrigerator. Protect from light.
Octreotide should be at room temperature when you inject it. Take the medicine out of the refrigerator 30 to 60 minutes before preparing your dose. Do not heat the medicine. After mixing your dose, give the injection right away. Do not save it for later use.
Prepare your dose only when you are ready to give yourself an injection. Do not use octreotide if it has changed colors or has particles in it. Call your pharmacist for new medication.
Your care provider will show you the best places on your body to inject octreotide. Use a different place each time you give an injection. Do not inject into the same place two times in a row.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
While using octreotide, you may need frequent medical tests.Each single-use ampul is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
If refrigeration is not available, you may store an unopened single-use ampul or multi-dose vial at room temperature for up to 14 days. Keep away from moisture and heat.
Throw away any medicine left in the multi-use vial after 14 days of use. Then start a new vial.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of octreotide.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include severe upper stomach pain, diarrhea, weight loss, warmth or tingling, numbness or cold feeling, unexplained muscle pain, weakness, weak pulse, fainting, or slow breathing (breathing may stop).
What should I avoid while using octreotide?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Octreotide powder is a man-made protein that is similar to a hormone in the body called somatostatin. Octreotide lowers many substances in the body such as insulin and glucagon (involved in regulating blood sugar), and chemicals that affect digestion.
Octreotide is used to treat acromegaly. Octreotide is also used to reduce flushing episodes and watery diarrhea caused by cancerous tumors (carcinoid syndrome) or tumors called vasoactive intestinal peptide tumors (VIP adenomas).
Octreotide may also be used for purposes not listed in this medication guide.
What is the most important information I should know about octreotide?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
SLIDESHOW
Always Hungry? You Just Might Have One Of These Conditions
What should I discuss with my healthcare provider before using octreotide?
You should not use octreotide if you are allergic to it.
To make sure you can safely use octreotide, tell your doctor if you have any of these other conditions:
diabetes;
gallbladder disease;
heart disease, high blood pressure, or heart rhythm disorder;
thyroid problems;
pancreatitis;
liver disease; or
kidney disease (or if you are on dialysis).
Octreotide is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Using octreotide can affect certain hormones that may make it easier for you to get pregnant, even if you were unable to get pregnant before. Talk to your doctor about using birth control to avoid unwanted pregnancy.
It is not known whether octreotide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I use octreotide?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Octreotide is injected under the skin, or into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine. Be sure to follow the instructions for the exact type of octreotide your doctor has prescribed for you.
Store octreotide in the original carton in the refrigerator. Protect from light.
Octreotide should be at room temperature when you inject it. Take the medicine out of the refrigerator 30 to 60 minutes before preparing your dose. Do not heat the medicine. After mixing your dose, give the injection right away. Do not save it for later use.
Prepare your dose only when you are ready to give yourself an injection. Do not use octreotide if it has changed colors or has particles in it. Call your pharmacist for new medication.
Your care provider will show you the best places on your body to inject octreotide. Use a different place each time you give an injection. Do not inject into the same place two times in a row.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
While using octreotide, you may need frequent medical tests.Each single-use ampul is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
If refrigeration is not available, you may store an unopened single-use ampul or multi-dose vial at room temperature for up to 14 days. Keep away from moisture and heat.
Throw away any medicine left in the multi-use vial after 14 days of use. Then start a new vial.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of octreotide.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include severe upper stomach pain, diarrhea, weight loss, warmth or tingling, numbness or cold feeling, unexplained muscle pain, weakness, weak pulse, fainting, or slow breathing (breathing may stop).
What should I avoid while using octreotide?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
1.Product Description
Semax powder is a drug produced and prescribed mostly in Russia and Ukraine for a broad range of conditions but predominantly for its purported nootropic, neuroprotective, and neurogenic/neurorestorative properties. It is aheptapeptide, synthetic analog of a fragment of adrenocorticotropic hormone (ACTH), ACTH (4-10), of the following structure: Met-Glu-His-Phe-Pro-Gly-Pro.
2.Basic Information
Name:Semax
Systematic(IUPAC)name: (2S)-1-[2-{[(2S)-1-[(2S)-2-{[2-{[(2S)-2-{[(2S)-2-amino-4-methylsulfanylbuta noyl]amino}-4-carboxybutanoyl]amino}-3-(1H-imidazol-5-yl)propanoyl]amino}-3 -phenylpropanoyl]pyrrolidine-2-carbonyl]amino}acetyl]pyrrolidine-2-carboxyl ic acid
CAS NO: 80714-61-0
Purity: over 98%
Molecular Formula:C37H51N9O10S
Appearance:white powder
3.Application
Medical uses for Semax include treatment of stroke, transient ischemic attack, memory and cognitive disorders, peptic ulcers, optic nerve disease, and to boost the immune system.
In animals, Semax rapidly elevates the levels and expression of brain-derived neurotrophic factor (BDNF) and its signaling receptor TrkB in the hippocampus, and rapidly activates serotonergic and dopaminergic brain systems.In accordance, it has been found to produce antidepressant-like and anxiolytic-like effects, attenuate the behavioral effects of exposure to chronic stress, and potentiate the locomotor activity produced by D-amphetamine.As such, it has been suggested that Semax may be effective in the treatment of depression,[12] as well as in attention deficit hyperactivity disorder (ADHD).
Semax powder is a drug produced and prescribed mostly in Russia and Ukraine for a broad range of conditions but predominantly for its purported nootropic, neuroprotective, and neurogenic/neurorestorative properties. It is aheptapeptide, synthetic analog of a fragment of adrenocorticotropic hormone (ACTH), ACTH (4-10), of the following structure: Met-Glu-His-Phe-Pro-Gly-Pro.
2.Basic Information
Name:Semax
Systematic(IUPAC)name: (2S)-1-[2-{[(2S)-1-[(2S)-2-{[2-{[(2S)-2-{[(2S)-2-amino-4-methylsulfanylbuta noyl]amino}-4-carboxybutanoyl]amino}-3-(1H-imidazol-5-yl)propanoyl]amino}-3 -phenylpropanoyl]pyrrolidine-2-carbonyl]amino}acetyl]pyrrolidine-2-carboxyl ic acid
CAS NO: 80714-61-0
Purity: over 98%
Molecular Formula:C37H51N9O10S
Appearance:white powder
3.Application
Medical uses for Semax include treatment of stroke, transient ischemic attack, memory and cognitive disorders, peptic ulcers, optic nerve disease, and to boost the immune system.
In animals, Semax rapidly elevates the levels and expression of brain-derived neurotrophic factor (BDNF) and its signaling receptor TrkB in the hippocampus, and rapidly activates serotonergic and dopaminergic brain systems.In accordance, it has been found to produce antidepressant-like and anxiolytic-like effects, attenuate the behavioral effects of exposure to chronic stress, and potentiate the locomotor activity produced by D-amphetamine.As such, it has been suggested that Semax may be effective in the treatment of depression,[12] as well as in attention deficit hyperactivity disorder (ADHD).
Nootropic Powder Semax ACTH (4-7) for Brain Immune
Semax powder is what's called a synthetic heptapeptide, meaning that it's a chain of 7 amino acids as a single molecule. Interestingly enough, the semax molecule mirrors a fragment of adrenocorticotropic hormone, which is released in the pituitary gland of humans in response to environmental stress.
It was originally developed in Moscow, Russia as a treatment mostly for neurological-related disorders, such as poor memory, depression, ADHD, and post-stroke treatment.
Additionally, Semax can be used as an immune-system booster or as a treatment for peptic ulcers, strangely enough.
Semax can also be used off-label as a nootropic, with many properties that make it quite suitable for regular use.
Benefits of Semax:
In between the 2 - 3 decades since semax was synthesized and tested, there have been numerous studies on animals and humans to see the benefits of the drug. One of the primary benefits of semax is as a cognitive enhancer. One 2 day study of power plant workers tested semax and memory formation. The 1 mg dose 1 hour prior to the exam showed a drastic increase in correct responses.
The mechanism for improving cognitive function relates to brain chemicals like BDNF and NGF. Semax can increase BDNF and NGF by 8 and 5 times the baseline. Numerous other studies have confirmed the increase in BDNF, which acts as a type of fertilizer for the brain to develop new neurological connections.
Another way semax improves cognitive abilities is through the increase of alpha brain wave states. EEG studies show semax can increase alpha brain waves in patients, but also can prevent negative EEG changes during stressful situations (hyperventilation).
The benefits for alpha brain waves may also help support positive mood enhancement and reducing anxiety. Semax benefits include reducing symptoms of stress and depression. The Journal of Psychophysiology published a study on the sedative effects of semax on those who were suffering from mental illness. Part of these benefits may come from an increase in serotonin turnover, which is traditionally done with SSRIs.
Finally, an interesting but not incredibly well-researched benefit of semax is as for stimulant potentiation. Studies show that semax in combination with stimulants (such as amphetamine) could increase the dopamine release from the drug. One study showed an increase of activity from 182% (just the amphetamine) versus 261% (amphetamine and semax).
Semax powder is what's called a synthetic heptapeptide, meaning that it's a chain of 7 amino acids as a single molecule. Interestingly enough, the semax molecule mirrors a fragment of adrenocorticotropic hormone, which is released in the pituitary gland of humans in response to environmental stress.
It was originally developed in Moscow, Russia as a treatment mostly for neurological-related disorders, such as poor memory, depression, ADHD, and post-stroke treatment.
Additionally, Semax can be used as an immune-system booster or as a treatment for peptic ulcers, strangely enough.
Semax can also be used off-label as a nootropic, with many properties that make it quite suitable for regular use.
Benefits of Semax:
In between the 2 - 3 decades since semax was synthesized and tested, there have been numerous studies on animals and humans to see the benefits of the drug. One of the primary benefits of semax is as a cognitive enhancer. One 2 day study of power plant workers tested semax and memory formation. The 1 mg dose 1 hour prior to the exam showed a drastic increase in correct responses.
The mechanism for improving cognitive function relates to brain chemicals like BDNF and NGF. Semax can increase BDNF and NGF by 8 and 5 times the baseline. Numerous other studies have confirmed the increase in BDNF, which acts as a type of fertilizer for the brain to develop new neurological connections.
Another way semax improves cognitive abilities is through the increase of alpha brain wave states. EEG studies show semax can increase alpha brain waves in patients, but also can prevent negative EEG changes during stressful situations (hyperventilation).
The benefits for alpha brain waves may also help support positive mood enhancement and reducing anxiety. Semax benefits include reducing symptoms of stress and depression. The Journal of Psychophysiology published a study on the sedative effects of semax on those who were suffering from mental illness. Part of these benefits may come from an increase in serotonin turnover, which is traditionally done with SSRIs.
Finally, an interesting but not incredibly well-researched benefit of semax is as for stimulant potentiation. Studies show that semax in combination with stimulants (such as amphetamine) could increase the dopamine release from the drug. One study showed an increase of activity from 182% (just the amphetamine) versus 261% (amphetamine and semax).
ust this week we have seen official images of the “Synth” and “Antlia”
Yeezy 350 V2 Boost emerge and we were waiting on the third and final
pair to be revealed and today was the lucky day. YeezyMafia decided to
bless social media with the North America and Latin America Exclusive
pair. And we got to say, official images look great.
The primeknit upper takes on a creamy look with off white and darker tones speckled throughout that come with tonal laces. The newly added feature of a translucent stripe flows across the midfoot that is dressed in a cream aesthetic. The silhouette also matches the other two pairs of Regional Exclusives and has an absent heel tab. To finish the design a cream and gum midsole encase the coveted full-length boost technology.
The adidas Yeezy Boost 350 V2 “Lundmark” will be releasing later this month in a Reflective version on July 11th and Non-Reflective version on July 13th at select retailers. The 3M covered pair will see a slightly elevated price of $250 while the NR pair will see the normal price tag of $220. Check out official images below and stay tuned to JustFreshKicks for updates as the release draws closer and other adidas Yeezy news.
UPDATE: The adidas Yeezy Boost 350 V2 “Lundmark” Non-Reflective will still release at it’s expected time and at select retailers, Yeezy Supply but Kanye and adidas look to be trying something new when it comes to the reflective iteration this time around. They are holding a draw on the adidas app that is going on right now that appears to be the only release besides a limited amount of select retailers. The draw closes on July 11th at 7:30 AM and results will be chosen at 8 AM so make sure to enter before then. We could possibly see them surprise drop on Yeezy Supply as well so always be on the lookout for that but at this time, we do not have any information on that. As always follow JustFreshKicks for the hottest and latest sneaker news and check out our release links here for your best chance at copping the adidas Yeezy Boost 350 V2 “Lundmark”.Yeezy 350 Outlet online with hgih quality
The primeknit upper takes on a creamy look with off white and darker tones speckled throughout that come with tonal laces. The newly added feature of a translucent stripe flows across the midfoot that is dressed in a cream aesthetic. The silhouette also matches the other two pairs of Regional Exclusives and has an absent heel tab. To finish the design a cream and gum midsole encase the coveted full-length boost technology.
The adidas Yeezy Boost 350 V2 “Lundmark” will be releasing later this month in a Reflective version on July 11th and Non-Reflective version on July 13th at select retailers. The 3M covered pair will see a slightly elevated price of $250 while the NR pair will see the normal price tag of $220. Check out official images below and stay tuned to JustFreshKicks for updates as the release draws closer and other adidas Yeezy news.
UPDATE: The adidas Yeezy Boost 350 V2 “Lundmark” Non-Reflective will still release at it’s expected time and at select retailers, Yeezy Supply but Kanye and adidas look to be trying something new when it comes to the reflective iteration this time around. They are holding a draw on the adidas app that is going on right now that appears to be the only release besides a limited amount of select retailers. The draw closes on July 11th at 7:30 AM and results will be chosen at 8 AM so make sure to enter before then. We could possibly see them surprise drop on Yeezy Supply as well so always be on the lookout for that but at this time, we do not have any information on that. As always follow JustFreshKicks for the hottest and latest sneaker news and check out our release links here for your best chance at copping the adidas Yeezy Boost 350 V2 “Lundmark”.Yeezy 350 Outlet online with hgih quality