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Basic Info.
Name:PRL-8-53
Chemical name:Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate
Synonyms:PRL-8053;PRL-8-53;Methyl 3-(2-(benzyl(Methyl)aMino)ethyl)benzoate hydrochloride;3-(2-Benzyl(methyl)aminoethyl)benzoic acid methyl ester hydrochloride;m-[2-(Benzylmethylamino)ethyl]benzoic acid methyl ester hydrochloride;Benzoic acid, 3-(2-(Methyl(phenylMethyl)aMino)ethyl)-, Methyl ester, hydrochloride
CAS 51352-87-5
MF:C18H22ClNO2
MW 319.82578
Shelf life:2 years
Purity:99%
Package:50g/foil bag or as your inquiry
Dosage:
Subjects in human trials have been given up to 100 mg a day and did not appear to develop any negative side effects.
Reference FOB Price:$1/g
MOQ:10g
Specification:ISO9001,USP,BP,GMP
Trade Mark:CQSP
Port:Shenzhen/Shanghai,China
Production Capacity:5000kg/month
Skype/E-mail : summer at chembj.com
Abstract
The effect of 3-(2-benzylmethylaminoethyl) benzoic acid methyl ester hydrochloride (PRL-8-53) on learning and on retention of verbal information in human subjects was investigated. Using the serial anticipation method under double-blind conditions it was found that PRL-8-53 causes slight improvement of acquisition. Retinetion of verbal information was found improved to a statistically significant degree (most P values better than 0.01, some better than 0.001). No significant changes were found for either visual reaction time or motor control after drug when compared with placebo values.
Description
PRL-8-53 (chemical name Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate) is a synthetic nootropic compound discovered in 1972 and patented in 1975 by the late Dr. Nikolaus Hansl, a neuropharmacologist at Creighton University in Omaha, Nebraska. Preliminary animal tests indicated that the compound was both safe and significantly nootropic, boosting avoidance learning in rodents with no adverse effects. But the real interest in PRL-8-53 was sparked by a 1978 study on human volunteers, which showed that a single dose of the compound could improve word retention scores by more than 200%.
HOW IT WORKS?
PRL-8-53's exact mechanisms of action are not well understood, but it is generally believed to regulate the brain's production of and response to several crucial neurotransmitters. In his reports on human and animal studies Hansl indicated that PRL-8-53 potentiates dopamine, partially restricts production of serotonin, and enhances the brain's response to acetylcholine.
Though Hansl's research report on the 1978 human study suggests those actions, it does not clearly delineate the mechanism of action.The fact that older subjects saw the most nootropic benefit from taking the drug supports the concept that dopamine modulation plays a major role in PLR-8-53's effects. Up-regulating the normal age-related lessening of dopamine production that is associated with cognitive decline could have a significant positive impact on both learning and memory.
Dosage
The only human study on PRL-8-53 was based on the ingestion of a single 5 mg dose. There is no data on the effectiveness or potential toxicity of any other dosage in humans.
SIDE EFFECTS
No adverse effects from a single 5 mg dose of PRL-8-53 were observed in the human study. Animal studies suggest that the compound has a high therapeutic threshold, but evidence is very limited because no comprehensive toxicity studies have been completed.
Lorcaserin Hydrochloride is an FDA-approved prescription weight-loss medication that, when used with diet and exercise, can help some overweight adults with a weight-related medical problem, or obese adults, lose weight and keep it off.Lorcaserin powder
Lorcaserin HCl is an FDA-approved prescription weight-loss medication
that, when used with diet and exercise, can help some overweight adults
with a weight-related medical problem, or obese adults, lose weight and
keep it off.
Lorcaserin hydrochlorideis a serotonin 2C receptor
agonist. It hasbeen shown to decrease food consumption and promote SA
tiety by selectivelyactivating serotonin 2C receptors in the brain.
Lorcaserin HCl is specifically indicated as an adjunct to a reduced-calorie diet andincreased physical activity for chronic weight management in clinically obeseadults (BMI of 30 kg/m2 or greater) and overweight adults (BMI of 27 kg/m2 orgreater) with at least one weight-related comorbid condition.
Lorcaserin HCl is supplied as a tablet designed for oral administration. The recommendeddose is one 10mg tablet twice daily. Use of Lorcaserin HCl should be discontinued if 5%weight loss is not achieved by week 12 of treatment.
Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric modulator of AMPA receptors, and has nootropic effects in animal studies with significantly higher potency than piracetam. A number of related compounds are known, the best known being unifiram (DM-232).Sunifiram powder
application:
Sunifiram is one of the newest nootropics on the
market to smart drugs family. It is considered to be in the ampakine
family of supplements. It increases one's attention span, decision
making, and learning abilities. Although it is believed to work much
like Piracetam, it is highly potent in comparison. The structure is
similar, but some have reported Sunifiram being 1000 times more potent.
In terms of its potency, it's comparable to Noopept.
It is being
researched as a memory enhancer, potentially treating Alzheimer's
patients. It provides a wide variety of benefits including; increased
attention span, improved focus, and increased learning potential. It has
become very popular since its release, as the benefits are high and the
side-effects are low.
How to Use Sunifiram:
Sunifiram is extremely potent, so small
doses should be taken. It has been said that it works best when taken
sublingually. This means that users place it under their tongue for
administration. This will generally be a little scoop of powder. Some
users have experienced a slight tingling, as you would with a breath
mint. Ingestion has been reported as easy.
Start with the smallest
dose, seeing how you feel. Most users report feeling the effects within
an hour of administration. You can always increase your dosage after a
week or so. Since dosing is still being studied, do not exceed 10 mg.
Use it sparingly or choose to cycle your doses. This means that you will
cycle 'on' and 'off.' Spreading out your doses over the course of the
week, and then taking a break.
When purchasing online, you may notice that Sunifiram costs slightly
more than other nootropics. Keep in mind that the dosage is much smaller
than other nootropics. You only need a little to achieve big results.
This is due to the potency offered.
Function:
Sunifiram activates AMPA-mediated neurotransmission.
Enhancing LTP in a bell-shaped dose-response relationship.
Sunifiram aids in the release of acetylcholine in the cerebral cortex.
Sunifiram increases energy levels, allowing users to feel more motivated and eliminate
Sunifiram increase Levels of concentration increase, and users feel less distracted by external stimuli.
Sunifiram also enhances long-term potentiation, which is the forming of new connections regarding memory storage.
Sunifiram has some anxiolytic benefits. Feeling more relaxed is beneficial when trying to focus.
The production of melatonin by the pineal gland is activated by darkness and . increased production and release of melatonin, and eventually of pinoline and Deep Breathing Techniques to - Meditation - (Ajna) Chakra. Pinoline is a methoxylated tryptoline (5-methoxytryptoline) long claimed to be produced in the Aluminium toxicity causes an increase in lipid peroxidation, with most damage occurring in the brain. Lipopolysaccharide is produced by Gram-negative bacteria and stimulates the production of free radicals which in turn. Pinoline also resonates with the very pulse of life 8 cycles per second, the pulse the .. and hence there is an increased production of Meltaonin and Pinoline.pinoline powder
Melatonin is then converted in small amounts to pinoline. Production of melatonin is inhibited by light on the retina and then increases in Melatonin also seems to boost the immune system and slow the aging process. hyde (MDA) plus 4-hydroxyalkenals (4-HDA) production as a reflection of lipid peroxidation. Below .. melatonin did not improve the activity of pinoline in. increases in length during the sleep cycle, often . REMS. Pinoline increases brain serotonin levels, production of psychedelic compounds to account.
The pineal gland starts to increase the production of 'pinoline', whereby a greater fluidity of thought and healing of the body starts to occur. (1) Pinoline and melatonin are both structurally related to serotonin .. 5-HT1A and 5-HT2 is known to increase the neurogenesis rate in adult rat brain. The production of H2O2 catalyzed by MAO isoforms was detected using. This "Third Eye,” in the center of the brain, is implicated in the production of endogenous .. DMT with Pinoline increases brain activation, and with its cousin the. SNP increased MDA + 4-HDA and carbonyl contents production in brain homogenates Keywords: Melatonin; Pinoline; Nitric oxide; Lipid peroxidation; Protein. Therefore, increased production of endogenous KYNA might (similar to exogenous antagonist, MK) inhibit NAS biosynthesis and contribute to.
Request PDF on ResearchGate | Antioxidant activity of pinoline analogues in the replacement of this methoxy by an Et side chain increased the antioxidant. Aging is associated with increased production of reactive oxygen species .. Pinoline and N-acetylserotonin reduce glutamate-induced lipid. Pinoline, 6-methoxy-1,2,3,4-tetrahydro-β-carboline, is a serotonin analog have impaired or deficient CYP2D6 activity, they may have increased risk so that the rates of metabolite production were within the linear ranges. question the relevance of the neuroendocrine production of pinoline. . nitrogen in γ-position abolished the binding to 5-HT1AR receptors, but increased the.
Anti-NMDA receptor encephalitis is a severe encephalopathic autoimmune disease, which affects mainly young women with ovarian teratoma, but also women without tumors, men and children. First described in 2007, it is a currently still widely under diagnosed disease entity (J. Dalmau et al., 2008, Lancet Neurol 7(12): 1091-1098).N-Methyl-D-Aspartic Acid
Diagnosis of anti-NMDA receptor encephalitis is based on the detection of highly specific autoantibodies directed against glutamate receptors of type NMDA in serum or cerebrospinal fluid. These autoantibodies are detected with high sensitivity and specificity in indirect immunofluorescence using a human recombinant cell line expressing the major target antigen (receptor subunit NR1). The determination of antibodies against glutamate receptors (type NMDA) is of high significance in patients with encephalitis where no pathogen has been detected, as well as in suspected cases of limbic encephalitis. The new cell substrate can be combined with various tissue substrates that are relevant for differential diagnostics (e.g. hippocampus and cerebellum) as BIOCHIP Mosaics, allowing the detection of further autoantibodies associated with limbic encephalitis (e.g. anti-VGKC antibodies, anti-AMPA receptor antibodies)
As we watch the 2016 Rio Olympic Games with the Russian doping scandal looming in the rearview mirror the notion that noopept could be the next big banned substance in sport after meldonium is interesting on its own. However, when one considers that both substances appear to be sold as medication in Russia, and that many of the meldonium findings early this year involved Russian athletes, the intrigue gets deeper. Because noopept is prevalent in the supplement marketplace around the world, if it is the next clandestine doping agent the potential issue would expand well beyond Russia.
A comparison between the substance noopept and meldonium supports our theory. Meldonium, which is suggested to improve blood flow, is approved for use as anti-ischemia medication in Eastern Europe and Russia. It is usually used to treat heart disease. Although clearly popular with athletes, based on the hundreds of adverse analytical findings for the drug in early 2016, meldonium is not commonly found as a dietary supplement, at least not yet.
Meanwhile, noopept, is patented by JSC LEKKO Pharmaceuticals, a Russian pharmaceutical company, in both the U.S. and Russia. It is commonly sold as a dietary supplement in the nootropic category around the world, but appears to be sold as a medication in Russia and Eastern Europe. Noopept is being studied for its potential to alleviate Alzheimer’s symptoms and treat other brain disorders. It is not an approved drug in the U.S.
Noopept does not appear to be a controlled substance in the U.S. or other countries, or at least that is what some nootropic sites claim. That does not mean, however, it would be legal to sell as a supplement. It would likely qualify as an unapproved drug according to the U.S. FDA, or other international equivalents. As such, it may be OK to sell for research purposes, but not as a supplement marketed for human consumption. Given that noopept was patented in 1996, was not in the food supply prior to 1994, and is synthetic, it does not appear to qualify as a legal dietary supplement ingredient in the U.S., according to DSHEA (the Dietary Supplement Health and Education Act of 1994).
Despite noopept being a dubious, if not illegal, supplement ingredient, it is commonly found packaged as a supplement and is available online at a wide range of distributors including Amazon.com and Jet.com. Based on its prevalence in dietary supplements and on message boards, it seems it has become quite popular. With discussion on ‘The Worlds Most Trusted Anabolic Website,’ as far back as 2007, it appears folks that track performance-enhancing compounds have known about it for a number of years.
In fact, noopept has become so popular that even Reddit, who thankfully realizes the concern, has a note on noopept in ‘New Rules in Regards to Illegal/Dangerous Compounds.’ The note describes that, “synthetic drugs (not DSHEA compliant) that have too little information on them to assess toxicity (Ex. Noopept or PRL-8-53)…, are in the grey area.”
Mobile phones can become office VoIP phones with the Invoxia 610, a device that Invoxia will be demonstrating at the International CES this week.fixed wireless gsm desk phone
Last year, the French company introduced the AudiOffice, an iPhone docking station with a wired handset and a set of six speakers for high-powered conference calling and music listening. Putting an iPhone in the dock made it into something like a full-size speakerphone, while the handset let consumers use it like a traditional desk phone.
Now Invoxia has combined those capabilities with VoIP in the NVX 610,
a version of its desk phone that plugs into an office network via
Ethernet. The company showed it off at a CES kickoff event on Sunday.
It's due to ship in the first quarter of this year.
With the new
system, workers can make and receive VoIP calls on the wired handset in
the unit, which has its own keypad and display, or from an Invoxia app
on their cell phone via Bluetooth.
It's a sleek, low, white unit that carries a list price of a cool US$599, which is $300 more than the original, non-VoIP Invoxia product. But it lets users tap into the cost savings and features of office VoIP with the phone they're most comfortable using or have with them at the moment. Speakerphone is still an option, too.
Invoxia also plans to expand the device options on its whole line this quarter by including a variety of dock interfaces for the iPhone 5 and for Android phones. An Android app is on the way to work with phones running any version of Android. There's even a special adapter that lets the user mount an iPad on the back of the device and plug it in via a standard iPad mount. Support for Android tablets will come later, said Pascal Dussiau, vice president of sales at Invoxia.
A new report by renowned analysts Mobile Experts says the global Fixed Wireless Access (FWA) equipment market will grow from a value of $3.2 billion last year to more than $6.2 billion by 2024 corresponding to a CAGR of 11% per year. Significant market expansion of 802.11-based systems in the 24-40 GHz and 60 GHz millimetre-wave bands contribute to the growth, Mobile Experts says.cdma fixed wireless terminal
The growth is consequential and sign of good years ahead for vendors working mostly with 802.11-based technology, such as Cambium Networks, Ubiquiti Networks, and others capable of extending products into new spectrum bands. By shipment volume of dedicated base station access points the market share for 802.11-based systems is about 75%, the company says.
Mobile Experts attributes most of the growth in 802.11-based FWA to
millimetre-wave systems. “While the overall 802.11-based FWA access
point shipment is forecasted to grow modestly at 2% CAGR from 2018 to
2024, those utilising the millimetre wave bands are expected to grow at
over 16% CAGR,” says Mobile Experts’ Principal Analyst Kyung Mun.
The report and forecast includes all of 4G, 5G, and 802.11-based
technologies. “Because 5G FWA systems are more costly and with numbers
primarily driven by CPE sales, 5G represents over half of the market
value for FWA although only about 40% of the actual CPE shipment volume
in 2024,” says Joe Madden, Founder & President of Mobile Experts.
Kyung Mun says the drivers are well known. “Fundamentally, people in
both urban and rural areas want faster Internet connectivity and an
increasing number of streaming options is aiding in this trend. The
pent-up demand is hard to ignore,” he says.
Mobile Experts is careful to point out that the report includes only ‘dedicated FWA networks’ and not FWA-type applications running on infrastructure shared with 4G or 5G. Shipment numbers include both radios and CPEs but excludes wireless backhaul, which are common in remote deployments, Mobile Experts says.
The global fixed wireless broadband market will grow 30% in 2018 and generate $18 billion in service revenue, forecasts market analysis firm ABI Research. By 2022, worldwide fixed wireless broadband market are expected to generate $45.2 billion, thanks to an estimated compound annual growth rate of 26%.cdma fixed wireless phone
Fixed wireless broadband delivers broadband via radio signals rather than cables to deliver broadband internet to customers, who have an outdoor antenna receiver mounted to the building and a Wi-Fi gateway inside. The connection is line-of-sight between the customer premises and a ground station.
Often fixed broadband options — DSL, cable or fiber alternatives — are limited in rural areas, explains network infrastructure company Ericsson in a blog. “Fixed wireless access (FWA) provides a bridge to those potential customers,” Ericsson said.
As RCR Wireless News reported in March, lots of small, rural carriers are working to extend reliable broadband in challenging economic and geographical settings.
For now, LTE is the most widely used technology to provide fixed wireless broadband service across the world, reports ABI Research. Verizon will launch its 5G fixed wireless in California this year and expects 30 million customers to be reached by that first deployment. AT&T and Charter are carrying out 5G fixed wireless broadband tests in select U.S. markets. Orange, Elisa, and telecom infrastructure company Arqiva are performing 5G fixed wireless trials in Europe. In APAC, Australia’s Optus is planning for 5G fixed wireless service launch in 2019, , according to ABI Research.
“5G fixed broadband access is expected to enable robust services with a reliable capacity to meet the need of residential broadband users,” said ABI Research Industry Analyst Khin Sandi Lynn in a statement. “5G technology can support a theoretical speed up to 20 Gbps with latency [of]1 ms, enabling operators to provide superior broadband access without installing fiber-optic cables to every single household,”
These findings are from ABI Research’s LTE and 5G Fixed Broadband Markets report, which lists 43 operators providing fixed wireless broadband access including AT&T, Bell, Orange, Telefonica, Verizon, etc. and customer premises equipment vendors including Arris, Huawei, Netgear, Sagemcom, Technicolor, ZyXel, ZTE, among others.
Neck band style headset comes with a dedicated button to bring up the voice assistant on your smartphone (Siri or Google Assistant). We liked that you can ask the voice assistant to perform functions using the headset without even unlocking or waking up your phone’s display. mobile in ear headphones
The neckband style headset has magnets on both earbuds so that they stick to each other when not in use. Build quality is good: buttons have a nice click to them; the neckband feels sturdy while the lightweight design makes them easy to wear for long duration.
In terms of audio output, we liked the loud volume output but the
bass output is average — if you like listening to a lot of bass heavy
music, avoid this headset. Another issue is that if you go over 70%
volume level, the output gets shrill. At full volume, the output starts
to hurt the ear after a few minutes of usage.
These headphones also
come with a dedicated button to bring up the voice assistant on your
smartphone (Siri or Google Assistant), just like the headset.
With the stereo headphone, we got much better bass compared to the neckband. However, at max volume, we felt the output gets muddy — bass overpowers treble and vocals. This would have been good for dance music lovers, but then the bass on the headphone lacks the thump one expects to enjoy this genre of music.
As long as you are under 70% volume level, the headphone delivers good audio. The good thing is that the on-ear design is comfortable to wear for long hours of usage and provided a good amount of noise isolation. The headphone also comes with option to use as a wired headset via a 3.5mm aux cable (provided in box) — useful if you run out of battery. On a single charge, we were able to get close to 8 hours of battery life which is impressive. It would have been great if SoundLogic also included a travel pouch in the box. Considering the aggressive competition in the budget audio segment, these headphones do offer a good feature (voice assistant button).
The trouble is that both have some small niggling issues. There are better options available from brands such as Boat, Tagg, Leaf and Mivi available at around the same price.