User blogs
A Greater Victoria couple who ran clandestine drug labs in North Saanich
and Shawnigan Lake has pleaded guilty to producing and selling anabolic
steroids.Steroids Supplier
“Your conduct was outrageous and it was dangerous,” Justice Geoff Gaul said as he sentenced Meagan Breanna Blake and her partner Christopher Hyland in B.C. Supreme Court.
You were chefs cooking up a serious cocktail of dangerous substances in a relatively sophisticated laboratory operation,” Gaul said.
“You then marketed these substances under a fictitious name using professional looking labels for profit. … Some, if not most, of those who purchased these substances from you had no idea whatsoever that Serivek Pharmaceuticals was a clandestine laboratory operation being run by two young adults.”
At the sentencing hearing last week, federal prosecutor Baljiner Girn told the court that Sidney-North Saanich RCMP started investigating a drug lab in an outbuilding rented by Blake on Quatsino Drive in North Saanich in December 2015.
They discovered that Canadian Border Service Agency agents had intercepted packages addressed to C. Hyland from Hong Kong containing anabolic steroids, Viagra, Cialis, Tamoxifen and GBL, which can be used to make the “date rape drug” GBH, according to a lengthy agreed statement of facts.
On March 10, 2016, armed with a general warrant, officers secretly entered the outbuilding and found two pill presses and an industrial powder mixer. The officers found labels with the name “Serivek Pharmaceuticals” and several pages of handwritten notes showing calculations of pills, and pill bottles, the statement said.
The officers took liquid and powder samples, which were analyzed by Health Canada and found to be GHB, three forms of anabolic steroids, Cialis, Viagra and Tamoxifen.
On May 26, officers again entered the lab and took samples of what turned out to be GBL, Letrozole (a cancer drug), and an anabolic steroid.
When officers made a third covert entry into the building on June 28, the lab was gone.
The next day, police saw Hyland leave a home on Ravenhill Drive in Shawnigan Lake with a large jerry can, which he placed near a car owned by another man, James Rempel. Hyland, Rempel and Blake got in the car.
Soon after, they were arrested by the Saanich police street crime section.
Officers found two 25-litre jerry cans filled with GHB and two water bottles of GBL. There was also a pH test kit in a bin on the back seat.
Police searched the Ravenhill home and found a lab, two pill presses and pills. An industrial power mixer was in the garage near canisters of raw anabolic steroids.
They also found vials of liquid anabolic steroids labelled Serivek Pharmaceuticals, three jugs of GBL and three kilograms of Viagra. In the kitchen, police found a large cooking pot with remnants of GHB.
According to the agreed statement of facts, the total volume of GBL seized was 75 litres.
“This volume of GBL converted to GHB would result in the production of 622 litres of GHB or 124,500 individual doses,” Girn told the court.
The street value would be more than $600,000, she said.
The total approximate value of the anabolic steroids and pharmaceuticals was $45,248.
Blake, 28, a former University of Victoria biology student, pleaded guilty to three counts of producing various anabolic steroids and three counts of possession of anabolic steroids for the purpose of trafficking.
Gaul accepted a joint submission and handed Blake an 18-month conditional jail sentence, 100 hours of community service and a $10,000 fine.
“Your conduct was outrageous and it was dangerous,” Justice Geoff Gaul said as he sentenced Meagan Breanna Blake and her partner Christopher Hyland in B.C. Supreme Court.
You were chefs cooking up a serious cocktail of dangerous substances in a relatively sophisticated laboratory operation,” Gaul said.
“You then marketed these substances under a fictitious name using professional looking labels for profit. … Some, if not most, of those who purchased these substances from you had no idea whatsoever that Serivek Pharmaceuticals was a clandestine laboratory operation being run by two young adults.”
At the sentencing hearing last week, federal prosecutor Baljiner Girn told the court that Sidney-North Saanich RCMP started investigating a drug lab in an outbuilding rented by Blake on Quatsino Drive in North Saanich in December 2015.
They discovered that Canadian Border Service Agency agents had intercepted packages addressed to C. Hyland from Hong Kong containing anabolic steroids, Viagra, Cialis, Tamoxifen and GBL, which can be used to make the “date rape drug” GBH, according to a lengthy agreed statement of facts.
On March 10, 2016, armed with a general warrant, officers secretly entered the outbuilding and found two pill presses and an industrial powder mixer. The officers found labels with the name “Serivek Pharmaceuticals” and several pages of handwritten notes showing calculations of pills, and pill bottles, the statement said.
The officers took liquid and powder samples, which were analyzed by Health Canada and found to be GHB, three forms of anabolic steroids, Cialis, Viagra and Tamoxifen.
On May 26, officers again entered the lab and took samples of what turned out to be GBL, Letrozole (a cancer drug), and an anabolic steroid.
When officers made a third covert entry into the building on June 28, the lab was gone.
The next day, police saw Hyland leave a home on Ravenhill Drive in Shawnigan Lake with a large jerry can, which he placed near a car owned by another man, James Rempel. Hyland, Rempel and Blake got in the car.
Soon after, they were arrested by the Saanich police street crime section.
Officers found two 25-litre jerry cans filled with GHB and two water bottles of GBL. There was also a pH test kit in a bin on the back seat.
Police searched the Ravenhill home and found a lab, two pill presses and pills. An industrial power mixer was in the garage near canisters of raw anabolic steroids.
They also found vials of liquid anabolic steroids labelled Serivek Pharmaceuticals, three jugs of GBL and three kilograms of Viagra. In the kitchen, police found a large cooking pot with remnants of GHB.
According to the agreed statement of facts, the total volume of GBL seized was 75 litres.
“This volume of GBL converted to GHB would result in the production of 622 litres of GHB or 124,500 individual doses,” Girn told the court.
The street value would be more than $600,000, she said.
The total approximate value of the anabolic steroids and pharmaceuticals was $45,248.
Blake, 28, a former University of Victoria biology student, pleaded guilty to three counts of producing various anabolic steroids and three counts of possession of anabolic steroids for the purpose of trafficking.
Gaul accepted a joint submission and handed Blake an 18-month conditional jail sentence, 100 hours of community service and a $10,000 fine.
Inhaling medication is often the optimal method of treating lung
disease. An inhaler is a device that helps deliver drugs into the
airways.buy steroids powder
This article provides an overview of inhaled steroids, including their uses and types. We also describe how to take them, how long these medications last, and their side effects.Inhaled steroids are treatments for breathing disorders.
There are several advantages to inhaling steroids, rather than taking them by mouth. Inhalation allows high levels of the drugs to reach the airways and low levels to reach the rest of the body. Taken orally, steroids have more wide-ranging effects.Some advantages to using inhaled steroids include smaller dosages and fewer adverse effects. Using inhaled steroids may also reduce the need for oral steroids.
Children and adults with asthma can use inhaled steroids alone or in combination with long-acting bronchodilators.
The Global Initiative For Asthma (GINA) recognize inhaled steroids as the most effective anti-inflammatory type of drug for asthma. GINA recommend inhaled steroids because they can:People with COPD often use a combination of an inhaled steroid and long-acting bronchodilator.
Or, they may use a combination inhaler that contains a steroid, a long-acting bronchodilator, and a long-acting muscarinic antagonist (LAMA).
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommend inhaled steroids plus long-acting bronchodilators for treating COPD. They also recommend a combination of an inhaled steroid, a long-acting steroid, and a LAMA for COPD.
This article provides an overview of inhaled steroids, including their uses and types. We also describe how to take them, how long these medications last, and their side effects.Inhaled steroids are treatments for breathing disorders.
There are several advantages to inhaling steroids, rather than taking them by mouth. Inhalation allows high levels of the drugs to reach the airways and low levels to reach the rest of the body. Taken orally, steroids have more wide-ranging effects.Some advantages to using inhaled steroids include smaller dosages and fewer adverse effects. Using inhaled steroids may also reduce the need for oral steroids.
Children and adults with asthma can use inhaled steroids alone or in combination with long-acting bronchodilators.
The Global Initiative For Asthma (GINA) recognize inhaled steroids as the most effective anti-inflammatory type of drug for asthma. GINA recommend inhaled steroids because they can:People with COPD often use a combination of an inhaled steroid and long-acting bronchodilator.
Or, they may use a combination inhaler that contains a steroid, a long-acting bronchodilator, and a long-acting muscarinic antagonist (LAMA).
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommend inhaled steroids plus long-acting bronchodilators for treating COPD. They also recommend a combination of an inhaled steroid, a long-acting steroid, and a LAMA for COPD.
Oral Cardarine Raw Gw501516 Powder On Sale
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The science behind how Cardarine GW-501516 is actually quite simple. Since it is a PPAR (Peroxisome proliferator-activated receptor beta) agonist it binds to the receptors. The gene activity is altered, which causes a change in energy output. This type of thing will cause a sharp boost in endurance in the body, allowing you to go harder and longer, without getting winded as easily.
From a 'bro' outlook your heart rate will not get as revved up while on this compound. Just imagine your heart was the RPM's on a car and you were pushing hard on the gas, well if you slam too hard the RPM's will go into the red zone causing your engine to burn up. If you added Cardarine (GW501516) to your car your RPM's would not go into the red, so you can 'rev up' your body the same way.
Keywords: Cardarine powder,Cardarine Powder,GSK-516 Powder,Raw Cardarine powder,Endurobol powder,
oral SARMs Cardarine powder,Endurobol raw powder,Cardarine cycles,Cardarine dosages,Cardarine effects,
Gw501516 oral liquid suspension 25mg/ml,Cardarine oral suspension 30mg/ml
The science behind how Cardarine GW-501516 is actually quite simple. Since it is a PPAR (Peroxisome proliferator-activated receptor beta) agonist it binds to the receptors. The gene activity is altered, which causes a change in energy output. This type of thing will cause a sharp boost in endurance in the body, allowing you to go harder and longer, without getting winded as easily.
From a 'bro' outlook your heart rate will not get as revved up while on this compound. Just imagine your heart was the RPM's on a car and you were pushing hard on the gas, well if you slam too hard the RPM's will go into the red zone causing your engine to burn up. If you added Cardarine (GW501516) to your car your RPM's would not go into the red, so you can 'rev up' your body the same way.
GW-501516 (Cardarine) is one of the most versatile performance enhancers
one will ever come across. Whether you are looking to drastically
increase endurance,melt fat,cut or recomp,GW will truly shine.In this
article,I am going to touch on the many ways and reason to incorporate
GW into every cycle that you run.There is a place for GW in every cycle,
regardless of the desired goal.It can only add extra benefits that will
further enhance the chances of accomplishing goals and maximizing
gains.Raw Cardarine powder
GW will only add positives to your cycle in every aspect as opposed to these other negative choices.GW can also work wonders when preparing for a competition. By incorporating GW into a prep cycle,you are allowing yourself to maximize the cleanliness of your gains by melting away fat with its usage.Another excellent benefit of GW is its ability to combat the negative impact that tren can have on a person's cardio performance.By adding GW into the equation, you will still be able to do cardio on atrenbolone cycle without all of the negative impacts. GW can be ran up to 12 weeks and should be ran between 10-20 mg a day.The optimal way to dose GW is to take one dose in the morning and another equivalent dose 12 hours later.It is a good option to take GW prior to your workout. GW can really work magic in so many ways and should be implemented on every cycle that you run.
GW-501516 Usage and Dosage :
It had been investigated as a potential treatment for obesity,diabetes,dyslipidemia and cardiovascular disease.GW501516 could be used by athletes as an ergogenic performance enhancing drug.The most common use of GW consists of the extreme amount of endurance and recovery increase.The other main use of GW-501516 is to aid in fat loss.GW-501516 has shown to melt away fat at a rapid pace.
There are two main uses with GW-501516. The first and most common use is that of increased endurance. GW has been banned for professional athletes due to the unfair advantage it provides to endurance athletes. Anyone want a drastic increase in endurance will find that GW truly shines in this aspect. It takes effect very quickly and the results can be staggering. A common dose of 10 mg day will provide a significant increase in endurance.
The second common usage with GW is that of fat loss. Many users turn to GW as it has shown to melt off fat while still being non-catabolic. You will find that you can still hold on to some muscle as you are losing fat. It helps when you are running it in conjunction with SARMS Ostarine and S4, to hold on to as much muscle as possible. A dosage of 10 mg a day will provide good amounts of fat loss, but an increase to 20 mg a day will provide much more in this area.
GW will only add positives to your cycle in every aspect as opposed to these other negative choices.GW can also work wonders when preparing for a competition. By incorporating GW into a prep cycle,you are allowing yourself to maximize the cleanliness of your gains by melting away fat with its usage.Another excellent benefit of GW is its ability to combat the negative impact that tren can have on a person's cardio performance.By adding GW into the equation, you will still be able to do cardio on atrenbolone cycle without all of the negative impacts. GW can be ran up to 12 weeks and should be ran between 10-20 mg a day.The optimal way to dose GW is to take one dose in the morning and another equivalent dose 12 hours later.It is a good option to take GW prior to your workout. GW can really work magic in so many ways and should be implemented on every cycle that you run.
GW-501516 Usage and Dosage :
It had been investigated as a potential treatment for obesity,diabetes,dyslipidemia and cardiovascular disease.GW501516 could be used by athletes as an ergogenic performance enhancing drug.The most common use of GW consists of the extreme amount of endurance and recovery increase.The other main use of GW-501516 is to aid in fat loss.GW-501516 has shown to melt away fat at a rapid pace.
There are two main uses with GW-501516. The first and most common use is that of increased endurance. GW has been banned for professional athletes due to the unfair advantage it provides to endurance athletes. Anyone want a drastic increase in endurance will find that GW truly shines in this aspect. It takes effect very quickly and the results can be staggering. A common dose of 10 mg day will provide a significant increase in endurance.
The second common usage with GW is that of fat loss. Many users turn to GW as it has shown to melt off fat while still being non-catabolic. You will find that you can still hold on to some muscle as you are losing fat. It helps when you are running it in conjunction with SARMS Ostarine and S4, to hold on to as much muscle as possible. A dosage of 10 mg a day will provide good amounts of fat loss, but an increase to 20 mg a day will provide much more in this area.
RAD140 is a highly effective, oral SARM currently being studied for both
anabolic and neuroprotective effects. RAD140 is in a class of androgen
receptor (AR) ligands that are tissue selective, developed to treat
muscle wasting associated with cancer, acute and chronic illness and
age-related muscle loss. Testolone powder
RAD140 (Testolone) is designed to replace testosterone in bodybuilding, getting your body to react in the same way as it would to a dose of the powerful hormone but without any of the nasty side effects. At the same time loss of fat tissue occurs, making it the ideal drug for bodybuilders and sports use.
Some of the future applications which have been penciled in for RAD140 include androgen deficiency, sarcopenia and muscle wasting diseases. So RAD140 could be of use to both the bodybuilding community and the general population. There are absolutely no androgenic side effects to RAD140 so if desired, women can use it within bodybuilding.
RAD–140(Testolone) Benefits:
1. RAD140 Faster buildup of muscular tissues that helps you achieve more gains in a shorter period of time
2. RAD140 Enhanced speed, stamina and endurance during high-intensity workouts
3. RAD140 SARM was also seen to help reduce the androgenic side effects that can be potentially caused by the same on the prostate.
4. RAD140 is a potent supplement that contains RAD 140, perfect for recomping and to help you build muscle and boost your strength to get that ripped physique you’ve always wanted.
5. RAD140 has anti-catabolic properties, so it will be a great help at preventing muscle wasting problems.
6. RAD140 is capable of increasing strength and muscle volume in a much shorter time, especially in those who are deficient in the male hormone testosterone
RAD140 (Testolone) is designed to replace testosterone in bodybuilding, getting your body to react in the same way as it would to a dose of the powerful hormone but without any of the nasty side effects. At the same time loss of fat tissue occurs, making it the ideal drug for bodybuilders and sports use.
Some of the future applications which have been penciled in for RAD140 include androgen deficiency, sarcopenia and muscle wasting diseases. So RAD140 could be of use to both the bodybuilding community and the general population. There are absolutely no androgenic side effects to RAD140 so if desired, women can use it within bodybuilding.
RAD–140(Testolone) Benefits:
1. RAD140 Faster buildup of muscular tissues that helps you achieve more gains in a shorter period of time
2. RAD140 Enhanced speed, stamina and endurance during high-intensity workouts
3. RAD140 SARM was also seen to help reduce the androgenic side effects that can be potentially caused by the same on the prostate.
4. RAD140 is a potent supplement that contains RAD 140, perfect for recomping and to help you build muscle and boost your strength to get that ripped physique you’ve always wanted.
5. RAD140 has anti-catabolic properties, so it will be a great help at preventing muscle wasting problems.
6. RAD140 is capable of increasing strength and muscle volume in a much shorter time, especially in those who are deficient in the male hormone testosterone
RAD-140 is a non-steroid selective androgen receptor modulator, or
SARM. RAD140 has demonstrated potent anabolic activity on muscle and
bone in preclinical studies and has completed 28-day preclinical
toxicology studies in both rats and monkeys.Testolone powder
Product Details:
Place of Origin: China
Product Name: Rad-140 (Testolone)
CAS No.: 1182367-47-0
Molecular Formula: C20H16ClN5O2
Molecular weight: 282.80892
Purity: 99.0%
Appearance: White crystalline fine powder
Certification: GMP, SFDA
Payment Terms:
Minimum Order Quantity: Ask
Payment Terms: Bitcoin, Money Gram, Bank Wire, Other
Delivery & Shipping Terms:
1. We will ship the goods within 1 days after payment.
2. We will ship the goods by UPS, EMS, DHL, TNT or FEDEX. We will choose the best courier depending on different countries, and find the safest way to deliver the goods for you.
3. Delivery time EMS: 5-14 days. DHL/UPS/FedEx: 4-7 days.
4. Customs in countries like Russia, Australia, Canada is very strict, but we can ensure 100% delivery.
5. As usual you can get the goods with in 4-7 days. If the goods were lost or not received for other reasons, we’ll resend.
Product Details:
Place of Origin: China
Product Name: Rad-140 (Testolone)
CAS No.: 1182367-47-0
Molecular Formula: C20H16ClN5O2
Molecular weight: 282.80892
Purity: 99.0%
Appearance: White crystalline fine powder
Certification: GMP, SFDA
Payment Terms:
Minimum Order Quantity: Ask
Payment Terms: Bitcoin, Money Gram, Bank Wire, Other
Delivery & Shipping Terms:
1. We will ship the goods within 1 days after payment.
2. We will ship the goods by UPS, EMS, DHL, TNT or FEDEX. We will choose the best courier depending on different countries, and find the safest way to deliver the goods for you.
3. Delivery time EMS: 5-14 days. DHL/UPS/FedEx: 4-7 days.
4. Customs in countries like Russia, Australia, Canada is very strict, but we can ensure 100% delivery.
5. As usual you can get the goods with in 4-7 days. If the goods were lost or not received for other reasons, we’ll resend.
As reported by Mamounas et al in The Lancet Oncology, the phase III NRG
Oncology/NSABP B-42 trial has shown no disease-free survival benefit
with 5 years of letrozole (Femara) vs placebo after 5 years of aromatase
inhibitor–based therapy in women with hormone receptor–positive
postmenopausal breast cancer.Raw Letrozole powder
Study Details
In the double-blind trial, conducted at 158 sites in the United States, Canada, and Ireland, 3,966 postmenopausal women with stage I–IIIA hormone receptor–positive breast cancer who were disease-free after approximately 5 years of treatment with an aromatase inhibitor or tamoxifen followed by an aromatase inhibitor were randomly assigned between September 2006 and January 2010 to receive 5 years of letrozole 2.5 mg per day (n = 1,983) or placebo (n = 1,983). The primary endpoint was disease-free survival, defined as time from randomization to breast cancer recurrence, second primary malignancy, or death. Follow-up information was available for 3,903 patients for the analysis of disease-free survival, including 1,950 in the letrozole group and 1,953 in the placebo group. The two-sided statistical significance level for disease-free survival was set at .0418 to adjust for previous interim analyses.
Disease-free survival events were observed in 292 patients in the letrozole group vs 339 patients in the placebo group (hazard ratio [HR] = 0.85, P = .048, which did not meet the prespecified significance level). Estimated disease-free survival at 7 years was 84.7% in the letrozole group vs 81.3% in the placebo group. In multivariate analysis adjusting for the significant prognostic factors of age, pathologic node status, previous tamoxifen use, and type of surgery, the HR for disease-free survival was 0.86 (P = .0501). A beneficial effect of letrozole was more pronounced in patients who underwent mastectomy, had received previous tamoxifen, and had a lowest bone mineral density score of –2.0 or less, although the differences in these groups were not statistically significant. The largest differences in disease-free survival events for the letrozole vs placebo groups were in distant recurrence (61 vs 87 events) and contralateral breast cancer (30 vs 59 events).
No significant difference in overall survival was observed for letrozole vs placebo (HR = 1.15, P = .22). Estimated 7-year overall survival was 91.8% vs 92.3%. A total of 93 patients died from breast cancer, including 46 in the letrozole group and 47 in the placebo group.
The most common grade 3 adverse events were arthralgia (3% vs 2
and back pain (2% vs 2.
The most common grade 4 adverse events were urinary tract infection,
hypokalemia, and left ventricular systolic dysfunction (four patients
each, < 1% each) in the letrozole group and thromboembolic events (8
patients, < 1in the placebo group.
The investigators concluded: “After 5 years of aromatase inhibitor–based therapy, 5 years of letrozole therapy did not significantly prolong disease-free survival compared with placebo. Careful assessment of potential risks and benefits is required before recommending extended letrozole therapy to patients with early-stage breast cancer.
Study Details
In the double-blind trial, conducted at 158 sites in the United States, Canada, and Ireland, 3,966 postmenopausal women with stage I–IIIA hormone receptor–positive breast cancer who were disease-free after approximately 5 years of treatment with an aromatase inhibitor or tamoxifen followed by an aromatase inhibitor were randomly assigned between September 2006 and January 2010 to receive 5 years of letrozole 2.5 mg per day (n = 1,983) or placebo (n = 1,983). The primary endpoint was disease-free survival, defined as time from randomization to breast cancer recurrence, second primary malignancy, or death. Follow-up information was available for 3,903 patients for the analysis of disease-free survival, including 1,950 in the letrozole group and 1,953 in the placebo group. The two-sided statistical significance level for disease-free survival was set at .0418 to adjust for previous interim analyses.
Disease-free survival events were observed in 292 patients in the letrozole group vs 339 patients in the placebo group (hazard ratio [HR] = 0.85, P = .048, which did not meet the prespecified significance level). Estimated disease-free survival at 7 years was 84.7% in the letrozole group vs 81.3% in the placebo group. In multivariate analysis adjusting for the significant prognostic factors of age, pathologic node status, previous tamoxifen use, and type of surgery, the HR for disease-free survival was 0.86 (P = .0501). A beneficial effect of letrozole was more pronounced in patients who underwent mastectomy, had received previous tamoxifen, and had a lowest bone mineral density score of –2.0 or less, although the differences in these groups were not statistically significant. The largest differences in disease-free survival events for the letrozole vs placebo groups were in distant recurrence (61 vs 87 events) and contralateral breast cancer (30 vs 59 events).
No significant difference in overall survival was observed for letrozole vs placebo (HR = 1.15, P = .22). Estimated 7-year overall survival was 91.8% vs 92.3%. A total of 93 patients died from breast cancer, including 46 in the letrozole group and 47 in the placebo group.
The most common grade 3 adverse events were arthralgia (3% vs 2
and back pain (2% vs 2.
The most common grade 4 adverse events were urinary tract infection,
hypokalemia, and left ventricular systolic dysfunction (four patients
each, < 1% each) in the letrozole group and thromboembolic events (8
patients, < 1in the placebo group.The investigators concluded: “After 5 years of aromatase inhibitor–based therapy, 5 years of letrozole therapy did not significantly prolong disease-free survival compared with placebo. Careful assessment of potential risks and benefits is required before recommending extended letrozole therapy to patients with early-stage breast cancer.
Tamoxifen has been shown to protect bone from estrogen-deficiency bone
loss and lower plasma cholesterol in the rat. A 10 µM solution has
exhibited fungicidal activity (optimal pH 7,5) against yeast cells of C.
albicans. It has been implemented in liver carcinogenesis in rats.
Other actions of tamoxifen are: Reduction of plasma levels of insulin-like growth factor; Induction of cells surrounding cancer cells to secrete transforming growth factor b; Inhibition of membrane lipid peroxidation probably by decreasing membrane fluidity.
Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Soluble in methanol (50 mg/mL with heat) or ethanol (10 mg/mL with sonication); very slightly soluble in water (0.3 mg/L at 20 °C; the pH is approximately 3.0-3.5), 0.02 N HCl (0.2 mg/mL at 37 °C), acetone or chloroform.www.aasraw.com/products/tamoxifen-citrate-nolvadex-powder /a>
Other actions of tamoxifen are: Reduction of plasma levels of insulin-like growth factor; Induction of cells surrounding cancer cells to secrete transforming growth factor b; Inhibition of membrane lipid peroxidation probably by decreasing membrane fluidity.
Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Soluble in methanol (50 mg/mL with heat) or ethanol (10 mg/mL with sonication); very slightly soluble in water (0.3 mg/L at 20 °C; the pH is approximately 3.0-3.5), 0.02 N HCl (0.2 mg/mL at 37 °C), acetone or chloroform.www.aasraw.com/products/tamoxifen-citrate-nolvadex-powder /a>
Raloxifene hydrochloride is the second generation of selective estrogen
receptor modulators (SERM) for the benzothiophene series. The drug is
similar to tamoxifen and exhibits estrogen receptor antagonist
(blocking) properties in some tissues as an estrogen receptor agonist
(activator) in other tissues.Raloxifene powder
The major change between these two agents is their tissue selectivity. Although raloxifene hydrochloride is a strong antiestrogen in the mammary gland and uterine tissue, it appears to be estrogen in the bones. This allows it to protect bone density and mimic the beneficial effects of endogenous estradiol. This is quite different from tamoxifen, tamoxifen in the breast and bone are anti-estrogen effect.
In the fight against estrogen, raloxifene hydrochloride has been approved by the FDA for the prevention and treatment of postmenopausal women with osteoporosis. Other potential uses are being studied, including treatment and prevention of cardiovascular disease, breast cancer, men's breast development, prostate cancer, acromegaly and uterine cancer.
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The major change between these two agents is their tissue selectivity. Although raloxifene hydrochloride is a strong antiestrogen in the mammary gland and uterine tissue, it appears to be estrogen in the bones. This allows it to protect bone density and mimic the beneficial effects of endogenous estradiol. This is quite different from tamoxifen, tamoxifen in the breast and bone are anti-estrogen effect.
In the fight against estrogen, raloxifene hydrochloride has been approved by the FDA for the prevention and treatment of postmenopausal women with osteoporosis. Other potential uses are being studied, including treatment and prevention of cardiovascular disease, breast cancer, men's breast development, prostate cancer, acromegaly and uterine cancer.
Usually products are send in discreet way,based on our rich in shipping products to every countries,we usually use disguised way.
The photo of food disguised package for your reference,which has passed through every countries smoothly,products are packed well in food box,which mixed with real visible chinese food,and in the express bill we will declare food and sample,customs just think it chinese food and release it.
Professional Manufacture: GUANGZHOU Quanao CHEMICAL CO,LTD is a legit and professional pharmaceutical manufacturer specialized in steroid hormone powders, steroid injectable liquids, peptides,pharmaceutical raw materials & its intermediate.Our factory is in Nanhu Shouyi Industrial District, just by the side of the beautiful South Lake in Wuhan. Our company integrates R&D,producing, operating and marketing into an organic whole.
Raloxifene hydrochloride is an estrogen agonist/antagonist, referred to
as a selective estrogen receptor modulator (SERM) and belongs to the
benzothiophene class of compounds. The biological actions of raloxifene
Hcl are largely mediated through binding to estrogen receptors.Raloxifene powder
This binding results in activation of estrogenic pathways in some tissues (agonism) and and the blockade of estrogenic pathways in other tissues (antagonism). The agonistic or antagonistic activity of raloxiffene depends on the extent of recruitment of coactivators and corepressors to estrogen receptor (ER) target gene promotors.
Raloxifene Hcl appears to act as an estrogen agonist in bone. It decreases bone resorption and bone turnover, increases bone mineral density and decreases fracture incidence.
Raloxifene Hydrochloride Application:
1) Raloxifene Hcl used to prevent & treat osteoporosis in women who have undergone menopause.
2) Raloxifene Hcl used to decrease the risk of developing invasive breast cancer in women who are at high risk of developing this type of cancer or who have osteoporosis. Raloxifene Hcl cannot be used to treat invasive breast cancer or to prevent invasive breast cancer from coming back in women who have already had the condition.
3) Raloxifene Hcl prevents and treats osteoporosis by mimicking the effects of estrogen to increase the density (thickness) of bone.
4) Raloxifene Hcl decreases the risk of developing invasive breast cancer by blocking the effects of estrogen on breast tissue, which may stop the development of tumors that need estrogen to grow.
This binding results in activation of estrogenic pathways in some tissues (agonism) and and the blockade of estrogenic pathways in other tissues (antagonism). The agonistic or antagonistic activity of raloxiffene depends on the extent of recruitment of coactivators and corepressors to estrogen receptor (ER) target gene promotors.
Raloxifene Hcl appears to act as an estrogen agonist in bone. It decreases bone resorption and bone turnover, increases bone mineral density and decreases fracture incidence.
Raloxifene Hydrochloride Application:
1) Raloxifene Hcl used to prevent & treat osteoporosis in women who have undergone menopause.
2) Raloxifene Hcl used to decrease the risk of developing invasive breast cancer in women who are at high risk of developing this type of cancer or who have osteoporosis. Raloxifene Hcl cannot be used to treat invasive breast cancer or to prevent invasive breast cancer from coming back in women who have already had the condition.
3) Raloxifene Hcl prevents and treats osteoporosis by mimicking the effects of estrogen to increase the density (thickness) of bone.
4) Raloxifene Hcl decreases the risk of developing invasive breast cancer by blocking the effects of estrogen on breast tissue, which may stop the development of tumors that need estrogen to grow.