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Celiprolol powder General Description Celiprolol powder is a medication in the class of beta blockers, used in the treatment of high blood pressure. It has a unique pharmacology: it is a selective β1 receptor antagonist, but a β2 receptor partial agonist. It is also a weak α2 receptor antagonist. Celiprolol powder is believed to provide clinical benefit for people with vascular Ehlers–Danlos syndrome by promoting normal collagen synthesis in the blood vessels, and by shifting the pressure load away from the vessels most prone to dissection and rupture. In 2019, a new drug application (NDA) for celiprolol was denied by the Food an the U.S. Food and Drug Administration (FDA), instead calling for an “adequate and well-controlled” trial to determine whether celiprolol reduced the risk of clinical events in patients with vEDS. Celiprolol is a vasoactive beta-1 selective adrenoceptor antagonist with partial beta-2 agonist activity. The beta-2 agonist activity is thought to account for its mild vasodilating properties. It lowers blood pressure in hypertensive patients at rest and on exercise. The effects on heart rate and cardiac output are dependent on the pre-existing background level of sympathetic tone. Under conditions of stress such as exercise, celiprolol attenuates chronotropic and inotropic responses to sympathetic stimulation. However, at rest minimal impairment of cardiac function is seen. Before you start the treatment, read the manufacturer’s printed information leaflet from inside the pack. It will give you more information about celiprolol and will provide you with a full list of the side-effects which you may experience from taking it. Take celiprolol exactly as your doctor tells you to. There are two strengths of tablet – 200 mg and 400 mg. It is usual to start by taking one 200 mg tablet daily, although your doctor may later increase this to the 400 mg strength tablet. You should take the tablet first thing in the morning, preferably ‘on an empty stomach’. This means that you should take the tablet at least 30 minutes before you have breakfast, or wait until two hours after you have eaten. Swallow the Celiprolol: A Unique Selective Adrenoceptor Modulator. Celiprolol is a β-blocker with a unique pharmacologic profile: it is a β1-andrenoceptor antagonist with partial β2 agonist activity. Given this combination of effects, celiprolol may be better described as a selective adrenoreceptor modulator. It has antihypertensive and antianginal properties and is indicated for those uses in various countries around the world. In the United States, however, the proposed indication for this drug will be for the treatment of vascular type Ehlers-Danlos syndrome, a rare connective tissue disorder characterized by fragile arterial structure and an increased risk of life-threatening vascular complications. By reducing heart rate and pulsatile pressure, celiprolol may reduce the mechanical stress on collagen fibers within the arterial wall and be of benefit in patients with vascular type Ehlers-Danlos syndrome. The largest investigation of celiprolol in vascular Ehlers-Danlos syndrome was prematurely terminated due to significant benefit with celiprolol in reducing arterial events in patients with this condition. Celiprolol, therefore, represents a β-blocker that is unique from others in its class in both its pharmacology and clinical applications.
The Most Powerful Health Care Product Antiaging Tomato Extract Lycopene Powder Tomatoes are rich in vitamins A and C and fibre , and are cholesterol free. An average size tomato (148 gram, or 5 oz) boasts only 35 calories. Furthermore, new medical research suggests that the consumption of lycopene - the stuff that makes tomatoes red - may prevent cancer. Lycopene is part of the family of pigments called carotenoids, which are natural compounds that create the colours of fruits and vegetables. For example, beta carotene is the orange pigment in carrots.As with essential amino acids, they are not produced by the human body. Lycopene is the most powerful antioxidant in the carotenoid family and, with vitamins C and E, protect us from the free radicals that degrade many parts of the body.Antiaging Powder Lycopene is a bright red carotene and carotenoid pigment and phytochemical found in tomatoes and other red fruits & vegetables, such as,GAC, red carrots, watermelons and papayas (but not strawberries or cherries). Although lycopene is chemically a carotene, it has no vitamin A activity. In plants, algae, and other photosynthetic organisms, lycopene is an important intermediate in the biosynthesis of many carotenoids, including beta carotene, responsible for yellow, orange or red pigmentation, photosynthesis, and photo-protection. Structurally, it is a tetraterpene assembled from eight isoprene units, composed entirely of carbon and hydrogen, and is insoluble in water. Lycopene is not an essential nutrient for humans, but is commonly found in the diet, mainly from dishes prepared with tomato sauce. When absorbed from the stomach, lycopene is transported in the blood by various lipoproteins and accumulates in the liver, adrenal glands, and testes. The related carotenoid antioxidant, beta-carotene, has been shown to increase the number of prostate cancer cases in a subset of patients, although this area of research remains controversial and ongoing. 1) Prevention and suppression of cancer; 2) Protection of the cardiovascular; 3) Anti-ultraviolet radiation; 4) Suppression mutagenesis; 5) Anti-aging and enhancing immunity; 6) Improving skin allergies; 7) Improving a variety of body tissues 8)With a strong hangover effect; 9) With the prevention of osteoporosis, lower blood pressure,reducing the exercise induced asthma, and other physiological functions; 10) Without any side effects, ideal for taking long-term care; 11) Preventing and improving prostatic hyperplasia; prostatitis and other urological diseases; 12) Helping to improve sperm quality, reduce the risk of infertility.
Nootropic Powder J147 Pharmaceutical Intermediate J147 powder was discovered based upon efficacy in multiple cell culture models of age-associated pathologies rather than exclusively amyloid metabolism. It is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques, etc. These pleiotrophic effects of a single molecule suggest that J147 has potential for the treatment of AD. J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques. Function: Enhance mental intelligence; Boost memory and leaning capabilities;Improve brain power to solve problems and protect it from any chemical or physical injury;Enhance motivation level;Enhance the control of cortical/subcortical brain mechanism;Improve sensory perception.
Pharmaceutical Grade Alpha Lipoic Acid Lipoic Acid CAS No.: 1077-28-7 EINECS No.: 200-534-6 Type: Vitamins, Antioxidant, Nutrition Enhancers Appearance: Slightly yellow crystal powder Application: 1.Alpha lipoic acid is a vitamin drugs, limited physical activity in its dextral, basically no physical activity in its Lipoic acid , and no side effects. 2.Alpha lipoic acid always used for acute and chronic hepatitis, liver cirrhosis, hepatic coma, fatty liver, diabetes, Alzheimer's disease ,and applies as an antioxidant health products. Packaging & Delivery Packaging Details: 25kg/carton Delivery Time: within 7 days after payment Product Description Alpha lipoic acid is a vitamin drugs, limited physical activity in its dextral, basically no physical activity in its Lipoic acid, and no side effects. It is always used for acute and chronic hepatitis, liver cirrhosis, hepatic coma, fatty liver, diabetes, Alzheimer's disease ,and applies as an antioxidant health products.Alpha-lipoic Acid powder 1.Alpha lipoic acid is a fatty acid found naturally inside every cell in the body. 2.Alpha lipoic acid is needed by the body to produce the energy for our body's normal functions. 3.Alpha lipoic acid converts glucose(blood sugar) into energy. 4.Alpha lipoic acid is also an antioxidant, a substance that neutralizes potentially harmful chemicals called free radicals. What makes alpha lipoic acid unique is that it functions in water and fat. 5. Alpha lipoic acid appears to be able to recycle antioxidants such as vitamin C and glutathione after they have been used up. Alpha lipoic acid increases the formation of glutathione.
People are drinking collagen powder Do a quick scroll through Instagram, and chances are you’ll see a slew of wellness and fitness personalities touting the benefits of collagen peptide powder and adding it to their smoothies.Antiaging Powder So what exactly is collagen and why are some people clamoring for it?“Collagen is a structural protein made up of amino acids that's found naturally in the connective tissue of our bodies, such as our skin, hair, muscles, bones and even blood vessels,” Keri Gans, registered dietitian nutritionist and author of The Small Change Diet, tells Yahoo Lifestyle. “It is essentially the ‘glue’ that holds our body together, enables us to move and find stability.” Adds Joshua Zeichner, MD, director of cosmetic and clinical research in Mount Sinai Hospital’s department of dermatology, “Collagen is the main protein in our skin that provides structure and support.”And it’s that structure and support that plays a role in keeping skin looking smooth, firm, and wrinkle-free. But collagen production slows down as we age, which is why many people are turning to consuming collagen peptides (also known as hydrolyzed collagen) in the hopes that the supplements will reverse or at least stave off skin aging. “The hope for ingestible collagen is that it helps strengthen our skin to improve the appearance of fine lines and wrinkles, as well as enhance skin texture,” Zeichner tells Yahoo Lifestyle. But does consuming collagen powder actually do anything? Possibly.“The true benefit of ingestible collagen is unclear,” says Zeichner. “Since collagen is a large molecule, it is broken down by our gut into smaller pieces. The smaller pieces and individual amino acids may serve as building blocks for new collagen production. I look at ingestible collagen similar to the way I look at eating a high-protein meal.” Adds Gans: “Many individuals believe the numerous health claims in regards to collagen. There are claims that it can reduce constipation, improve gut health, improve sleep, decrease anxiety, reduce joint pain, eliminate food cravings and has anti-aging properties.” What are the benefits? Although more research is needed, there are some studies that have looked into collagen supplements’ potential benefits — particularly for easing joint pain. “Some preliminary research suggests collagen supplements may help reduce knee pain among people with osteoarthritis, and help reduce joint deterioration in athletes,” says Gans. While it’s no fountain of youth, there is some good news for people who are consuming collagen hoping to improve their skin and hair. “One small study revealed collagen supplements improved skin elasticity, but didn't do any more than a placebo to improve skin moisture and evaporation,” says Gans. A 2019 review of several studies showed that collagen supplements increase skin elasticity and hydration. It may also help with brittle, fragile nails. A small 2017 study in the Journal of Cosmetic Dermatology found that consuming collagen peptides daily for 24 weeks helped prevent nail breakage, increase nail growth, and improved the appearance of brittle nails. How safe is it? Collagen supplements are considered safe for the most part — as Zeichner puts it: “The only harm is to your pocketbook, as many of the collagen powders are pricey.” However, it’s important to read up on the source of the supplement’s main ingredient. The collagen found in supplements is typically sourced from cow (bovine) hides, as well as chicken cartilage, but in some cases they can be made from fish or eggs, which can be dangerous for people with those food allergies. “As with any supplement, one should read the label closely to make sure it doesn’t include any allergens that they are sensitive to,” suggests Gans. “Also, if on any medications a person should discuss with their doctor or a registered dietitian before implementing in their daily diet.” If you’re interested in trying collagen peptides powder, your best bet is to stick with a well-known brand, such as Vital Proteins. As Gans points out: “Like all supplements, collagen is not closely regulated by the Food and Drug Administration — therefore, one should choose nationally-recognized brands or store brands from a retailer they trust. Consumers can also look for a seal from a third-party certifier, such as NSF International, UL or USP.” You may also want to start with unflavored collagen peptide powder, which you can add to smoothies, as well as hot and cold beverages like coffee, without altering the flavor.
Glutathione Powder Antiaging Glutathione (GSH) is an important antioxidant in plants, animals, fungi and some bacteria and archaea. Glutathione prevents damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides and heavy metals. It is a tripeptide having a gamma peptide bond between the carboxyl group of glutamic acid side chain and the amine group of cysteine, and the carboxyl group of cysteine is linked to glycine through a normal peptide bond.L(+)-Arginine The thiol group is a reducing agent and is present in animal cells at a concentration of about 5 mM. Glutathione reduces disulfide bonds formed in the cytoplasm to cysteines by acting as electron donors. In this process, glutathione is converted to its oxidized form, glutathione disulfide (GSSG), also known as L - (-) - glutathione. Once oxidized, glutathione can be reduced by glutathione reductase, using NADPH as the electron donor. The ratio of reduced intracellular glutathione to oxidized glutathione is commonly used as a measure of cellular oxidative stress. Functions and Usages Glutathione exists in both reduced (GSH) and oxidized (GSSG) states. In the reduced state, the sulfhydryl group of cysteine is capable of providing reducing equivalents (H ++ e-) to other molecules, such as reactive oxygen species to neutralize them, or to maintain their reduced form for the protein cysteine. By donating electrons, glutathione itself becomes reactive and easily reacts with another active glutathione to form glutathione disulfide (GSSG). This reaction is most likely due to the relatively high concentration of glutathione in cells (up to 7 mM in the liver). In general, the interaction between GSH and other molecules with higher relative electrophilicity depletes intracellular GSH levels. An exception to this situation relates to the sensitivity of GSH to the relative concentration of electrophilic compounds. At high concentrations, the organic molecule diethyl maleate completely depletes the GSH levels in the cells. However, at low concentrations, cellular GSH levels decreased slightly and then tripled. GSH can be regenerated from GSSG by glutathione reductase (GSR): NADPH decreases the FAD present in GSR to produce transient FADH anions. This anion then rapidly disrupts the disulfide bond (Cys58-Cys63) and causes Cys63 to nucleophilic attack the nearest sulfide unit in the GSSG molecule (promoted by His467), resulting in a mixed disulfide bond (GS-Cys58) and GS- anion . His467 of GSR then protons the GS- anion to form the first GSH. Next, Cys63 nucleophile attacks the sulfide of Cys58, releasing the GS-anion, which in turn extracts solvent protons and releases it from the enzyme, resulting in a second GSH. Thus, for each GSSG and NADPH, two reduced GSH molecules are obtained that can again act as antioxidants to scavenge reactive oxygen species in the cells. In healthy cells and tissues, more than 90% of the total glutathione pool is reduced (GSH) and less than 10% exists as disulfide (GSSG). Increased GSSG to GSH ratio is considered an indicator of oxidative stress.
New Sarms ACP105 Raw Powder Muscle Building ACP-105 Product Name:ACP-105 CAS NO.:899821-23-9 Molecular Formula:C12H19ClN2O Purity:99% Appearance:White Powder Grade:Pharmaceutical Grade Description: ACP-105 can be taken orally and may be an effective SARM ACP-105, a novel non-steroidal SARM. ACP-105 is shown to be as potent and efficacious as testosterone in in vitro assays without interaction at other hormone receptors. In addition, ACP-105 demonstrates potent anabolic effects on muscle and bone with minimal effect on prostrate in preclinical models.Best Sarms Powder ACP-105 is a non-steroidal and selective androgen receptor agonist. ACP-105 is part of a class of molecules referred to as selective androgen receptor modulators (SARMs). SARMs may advance the standard of treatment for a variety of disorders including muscle-wasting conditions and osteoporosis, with fewer side effects as compared to current treatments based on testosterone replacement. ACP-105 has exhibited promising pharmacological properties and a favorable safety profile in preclinical testing.
Nootropics Ropinirole Hydrochloride Pharmaceutical powder for Parkinson′s Disease Product Name: 4-(2-Di-n-propylaminoethyl)-1,3-dichloro-2H-indol-2-one hydrochloride CAS: 91374-20-8 Standard: Enterprise Standard Natural / synthetic: synthetic Level: Pharmaceutical grade Content: 99% Appearance: white crystal Packing: 25KG/ cardboard drum Area: Early idiopathic Parkinson's disease Deferred product: Parkinson's drug Application: Acting on postsynaptic receptors in the striatum, compensating for the deficiency of dopamine, and compensating for increased sympathetic tone. Ropinirole can also be used for adjuvant treatment of patients who have already had switching problems. It can directly act on synaptic receptors, and it can produce continuous stimulation, thus alleviating the movement fluctuation of L-dopa, reducing its movement difficulty and reducing the dosage.Best Nootropics powder Nootropics Ropinirole Hydrochloride Pharmaceutical powder for Parkinson's Disease Description: Ropinirole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease. Ropinirole is used to treat symptoms of Parkinson's disease (stiffness, tremors, muscle spasms, and poor muscle control). Ropinirole is also used to treat restless legs syndrome (RLS). Only immediate-release ropinirole (Requip) is approved to treat either Parkinson symptoms or RLS. Extended-release ropinirole (Requip XL) is approved only to treat Parkinson symptoms. Parkinson's and RLS are two separate disorders. Having one of these conditions will not cause you to have the other condition.Nootropics Ropinirole Hydrochloride Pharmaceutical powder for Parkinson's Disease Dosage: The recommended starting dose for Parkinson's disease is 0.25 mg three times daily. Based on individual patient therapeutic response and tolerability, if necessary, the dose should then be titrated with weekly increments as described in Table 1. After Week 4, if necessary, the daily dose may be increased by 1.5 mg/day on a weekly basis up to a dose of 9 mg/day, and then by up to 3 mg/day weekly up to a maximum recommended total daily dose of 24 mg/day (8 mg three times daily). Doses greater than 24 mg/day have not been tested in clinical trials.
Smart Nootropics Alpha GPC CAS 28319-77-9 for Memory Improve L-Alpha Glycerylphosphorylcholine (Alpha GPC, choline alfoscerate) 28319-77-9 is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and is used as a nootropic dietary supplement to enhance memory and cognition.nootropics What's the other name of Alpha GPC CAS 28319-77-9 ? Alpha -GPC, Alpha Glycerol Phosphoryl Choline, Alpha-Glyceryl Phosphoryl Choline, Alpha-Glyceryl Phosphatidylcholine, Alpha-glycerylphosphorylcholine, Choline alphoscerate, Glycerophosphorylcholine, GPC, GroPCho, L-A-Glyceryl Phosphorylcholine, L-alpha-glycerylphosphorylcholine How does Alpha GPC CAS 28319-77-9 work?