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Oxiracetam is an all-around potent nootropic. It is more potent than Piracetam and has been known to offer stimulating effects. Alternatively, it can have the opposite effects of causing fatigue which suggests that levels of choline may not be adequate in these individuals. Nevertheless, Oxiracetam is still a favorite nootropic for many and can be used by itself or stacked with other nootropics.Oxiracetam powder
The cost of Oxiracetam is higher than Piracetam but the potency is much higher. It is a great nootropic that can be used selectively or on a routinely basis. Overall, it improves cognition and memory and may provide an increase in sensory perception or reflexes in some users. This is based on personal reports and there is limited data to suggest which areas of benefit Oxiracetam may be prominent in from a scientific perspective.
These are just some of the common qualities of Oxiracetam and you may experience other benefits. Others may feel little to no effect or they may be too subtle to realise. Often stacking with other nootropics can help enhance effects. Oxiracetam has little tolerance or dependence problems and overdose is unreported. The most common side effect may be headaches and in this case, supplementation with a choline source like, Alpha GPC or CDP-Choline is recommended.
OXIRACETAM SAFETY & SIDE-EFFECTS
Like most of the other racetams, Oxiracetam has been considered fairly safe to use. It is non-toxic and its low potency reduces the risk of overdose. No overdose reports causing death or severe side-effects have been reported. Commonly, overdose symptoms will relate to headaches or fatigue and will often result in opposite nootropic effects. Oxiracetam is well tolerated in most individuals. Some individuals may be sensitive to the substance and it is recommended to use a lower dose for the first time to observe the level of sensitivity.
Oxiracetam may have interactions with Carbamazepine. Carbamazepine is a common anti-convulsant and mood-stabilizing drug popular in treatment of bi-bipolar and depressive disorders. Carbamazepine has many drug interactions and is known under many trade names. The interaction of Carbamazepine with Oxiracetam does not appear to be life threatening. Only minor side effects seem to result from the interaction and Oxiracetam`s half-life and effects are commonly counter-acted.
Buying nootropics powders is not as easy as buying a standard dietary
supplement. This is perhaps because they are highly regulated
ingredients that not anybody can produce or sell. Very few manufacturers
are allowed to sell nootropics powders..Oxiracetam
Yangpu – There is good news for those who wish to buy IDRA-21 and other
powders that are meant solely for cognitive performance. They are not
that easily available. If available, they are not pure. However,
widepowder.com, a popular Chinese company, is known for selling these
nootropics powders online.
Wisepowder is a provider of a variety of pharmaceutical chemicals, biochemicals, and nutrition supplements as well as a maker of nutritional ingredients. Wish to buy Oxiracetam powder? Want to buy Pramiracetam powder? Both powders along with IDRA-21 and other smart drugs for boosting mental functions such as attention, motivation, and memory are available here.
However, buyers cannot buy them directly unlike other e-commerce or shopping portals. They need to fill a contact form on the corresponding nootropic’s informative page. For an available nootropic, interested buyers can go through this page.
This is where they will find information about that nootropic in detail. These details include description, history, mechanism of action, application, and more research. It also includes base information such as purity in %, form, appearance, half-life, solubility, and storage condition.
According to a spokesperson, “We recognize the fact that it is challenging to buy nootropics in their purest possible form. While it is not possible to get 100% pure form, it is possible to get 98 or 99% purity. This is possible only if the manufacturer is genuine and strict enough to adhere to all related rules and regulations. This is what we are exactly doing so that the probable seekers can get these cognitive ingredients in their purest form.”
About Wisepowder
With more than 20 years of experience, Wisepowder is a famous and esteemed company belonging to the Chinese nutraceutical industry. It specializes in researching, innovating, and manufacturing ingredients for nutrition as well as nootropic supplements. All its ingredients go through a stringent quality control system that is as per the GMP regulations.
Nootropics Phenylpiracetam / Carphedon CAS 77472-70-9
Phenylpiracetam powder/Carphedon/phenotropil CAS 77472-70-9
Henylpiracetam, is a Phenylpiracetam product with nootropic effects.
Experimental studies have proved it to be effective in improving memory
and learning capacity.
This medicine has a sedative effect, which
does not influence the activity of the autonomous nervous system. Its
action is mildly disinhibitory and antidepressant.
Phenylpiracetam is a nootropic drug derived from piracetam, and is more
potent (i.e. lower dosage is used). It belongs to the racetam family of
nootropics.
Phenylpiraceta was developed by Parke-Davis based on Piracetam, and is
8-30 times stronger than Piracetam. It goes by the trade name Neupramir
or Pramistar .Phenylpiracetam is widely believed to have first been
created in Russia in the early 1990s.
Pharmacological studies have shown that Phenylpiracetam stimulates
certain neuronal receptors in the Central Nervous System (CNS) that are
involved in memory and thought processes, such as the acetylcholine
transmitters, GABA receptors, and NDMA receptors. Phenylpiracetam has
also shown to increase dopamine receptors (D1, D2, and D3) activity.
We love how this mindbodygreen.com article describes L-theanine as, “the closest thing we’ve got to meditation in a bottle.” This article also describes several other benefits associated with this amino acid, from boosting attention, mood and sleep quality to boosting creativity.*
Suntheanine is a clinically proven, Non-GMO Project Verified L-theanine supplement. It’s produced via a patented process that results in 100 percent pure L-theanine, ensuring safety, potency, consistency and quality.
Here’s a quick look at what mindbodygreen had to say about L-theanine:
L-theanine promotes a soothing brain wave pattern.*
L-theanine
has been clinically shown to increase alpha brain waves. These brain
waves promote relaxation without drowsiness.* “Alpha brain-wave
production also happens during deep meditation, when sensory inputs are
minimized and the mind is generally clear of unwanted thoughts or
distractions. Interestingly, stimulating alpha waves has also been shown
to boost creativity and alleviate depression.”
Human clinical trials have shown that Suntheanine increases alpha brain waves, as well as decreases beta brain waves. Beta waves promote an excited state.
L-theanine may help support attention and working memory.*
According to the article, green tea consumption – L-theanine is
naturally found in green tea – has been shown to enhance performance on
tests of working memory by increasing connectivity within the brain
during processing. “This is a fascinating discovery because activity in
the frontal region of the brain is correlated to executive function,
while the parietal region handles sensory input.”
L-theanine may slow or reduce cognitive decline.
The article
references a study which showed that elderly individuals who consumed
L-theanine-enriched green tea powder had reduced cognitive decline
compared with a placebo group.
L-theanine may help improve mood.*
L-theanine helps improve the
production of GABA, a relaxing neurotransmitter. “GABA is important for
nervous system function; (it’s) often used as a natural supplement to
promote sleep, improve mood, and ease anxiety,” the article explains.
L-theanine may improve sleep quality*
L-theanine encourages
relaxation which helps calm the mind, making it easier to get longer and
more restful sleep. The article also references a clinical study which
used Suntheanine. In this study, researchers demonstrated that
Suntheanine safely and effectively improved the sleep quality of 8 to
12-year-old boys with ADHD.
Basic Info.
Name:PRL-8-53
Chemical name:Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate
Synonyms:PRL-8053;PRL-8-53;Methyl 3-(2-(benzyl(Methyl)aMino)ethyl)benzoate hydrochloride;3-(2-Benzyl(methyl)aminoethyl)benzoic acid methyl ester hydrochloride;m-[2-(Benzylmethylamino)ethyl]benzoic acid methyl ester hydrochloride;Benzoic acid, 3-(2-(Methyl(phenylMethyl)aMino)ethyl)-, Methyl ester, hydrochloride
CAS 51352-87-5
MF:C18H22ClNO2
MW 319.82578
Shelf life:2 years
Purity:99%
Package:50g/foil bag or as your inquiry
Dosage:
Subjects in human trials have been given up to 100 mg a day and did not appear to develop any negative side effects.
Reference FOB Price:$1/g
MOQ:10g
Specification:ISO9001,USP,BP,GMP
Trade Mark:CQSP
Port:Shenzhen/Shanghai,China
Production Capacity:5000kg/month
Skype/E-mail : summer at chembj.com
Abstract
The effect of 3-(2-benzylmethylaminoethyl) benzoic acid methyl ester hydrochloride (PRL-8-53) on learning and on retention of verbal information in human subjects was investigated. Using the serial anticipation method under double-blind conditions it was found that PRL-8-53 causes slight improvement of acquisition. Retinetion of verbal information was found improved to a statistically significant degree (most P values better than 0.01, some better than 0.001). No significant changes were found for either visual reaction time or motor control after drug when compared with placebo values.
Description
PRL-8-53 (chemical name Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate) is a synthetic nootropic compound discovered in 1972 and patented in 1975 by the late Dr. Nikolaus Hansl, a neuropharmacologist at Creighton University in Omaha, Nebraska. Preliminary animal tests indicated that the compound was both safe and significantly nootropic, boosting avoidance learning in rodents with no adverse effects. But the real interest in PRL-8-53 was sparked by a 1978 study on human volunteers, which showed that a single dose of the compound could improve word retention scores by more than 200%.
HOW IT WORKS?
PRL-8-53's exact mechanisms of action are not well understood, but it is generally believed to regulate the brain's production of and response to several crucial neurotransmitters. In his reports on human and animal studies Hansl indicated that PRL-8-53 potentiates dopamine, partially restricts production of serotonin, and enhances the brain's response to acetylcholine.
Though Hansl's research report on the 1978 human study suggests those actions, it does not clearly delineate the mechanism of action.The fact that older subjects saw the most nootropic benefit from taking the drug supports the concept that dopamine modulation plays a major role in PLR-8-53's effects. Up-regulating the normal age-related lessening of dopamine production that is associated with cognitive decline could have a significant positive impact on both learning and memory.
Dosage
The only human study on PRL-8-53 was based on the ingestion of a single 5 mg dose. There is no data on the effectiveness or potential toxicity of any other dosage in humans.
SIDE EFFECTS
No adverse effects from a single 5 mg dose of PRL-8-53 were observed in the human study. Animal studies suggest that the compound has a high therapeutic threshold, but evidence is very limited because no comprehensive toxicity studies have been completed.
Lorcaserin Hydrochloride is an FDA-approved prescription weight-loss medication that, when used with diet and exercise, can help some overweight adults with a weight-related medical problem, or obese adults, lose weight and keep it off.Lorcaserin powder
Lorcaserin HCl is an FDA-approved prescription weight-loss medication
that, when used with diet and exercise, can help some overweight adults
with a weight-related medical problem, or obese adults, lose weight and
keep it off.
Lorcaserin hydrochlorideis a serotonin 2C receptor
agonist. It hasbeen shown to decrease food consumption and promote SA
tiety by selectivelyactivating serotonin 2C receptors in the brain.
Lorcaserin HCl is specifically indicated as an adjunct to a reduced-calorie diet andincreased physical activity for chronic weight management in clinically obeseadults (BMI of 30 kg/m2 or greater) and overweight adults (BMI of 27 kg/m2 orgreater) with at least one weight-related comorbid condition.
Lorcaserin HCl is supplied as a tablet designed for oral administration. The recommendeddose is one 10mg tablet twice daily. Use of Lorcaserin HCl should be discontinued if 5%weight loss is not achieved by week 12 of treatment.
Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric modulator of AMPA receptors, and has nootropic effects in animal studies with significantly higher potency than piracetam. A number of related compounds are known, the best known being unifiram (DM-232).Sunifiram powder
application:
Sunifiram is one of the newest nootropics on the
market to smart drugs family. It is considered to be in the ampakine
family of supplements. It increases one's attention span, decision
making, and learning abilities. Although it is believed to work much
like Piracetam, it is highly potent in comparison. The structure is
similar, but some have reported Sunifiram being 1000 times more potent.
In terms of its potency, it's comparable to Noopept.
It is being
researched as a memory enhancer, potentially treating Alzheimer's
patients. It provides a wide variety of benefits including; increased
attention span, improved focus, and increased learning potential. It has
become very popular since its release, as the benefits are high and the
side-effects are low.
How to Use Sunifiram:
Sunifiram is extremely potent, so small
doses should be taken. It has been said that it works best when taken
sublingually. This means that users place it under their tongue for
administration. This will generally be a little scoop of powder. Some
users have experienced a slight tingling, as you would with a breath
mint. Ingestion has been reported as easy.
Start with the smallest
dose, seeing how you feel. Most users report feeling the effects within
an hour of administration. You can always increase your dosage after a
week or so. Since dosing is still being studied, do not exceed 10 mg.
Use it sparingly or choose to cycle your doses. This means that you will
cycle 'on' and 'off.' Spreading out your doses over the course of the
week, and then taking a break.
When purchasing online, you may notice that Sunifiram costs slightly
more than other nootropics. Keep in mind that the dosage is much smaller
than other nootropics. You only need a little to achieve big results.
This is due to the potency offered.
Function:
Sunifiram activates AMPA-mediated neurotransmission.
Enhancing LTP in a bell-shaped dose-response relationship.
Sunifiram aids in the release of acetylcholine in the cerebral cortex.
Sunifiram increases energy levels, allowing users to feel more motivated and eliminate
Sunifiram increase Levels of concentration increase, and users feel less distracted by external stimuli.
Sunifiram also enhances long-term potentiation, which is the forming of new connections regarding memory storage.
Sunifiram has some anxiolytic benefits. Feeling more relaxed is beneficial when trying to focus.
The production of melatonin by the pineal gland is activated by darkness and . increased production and release of melatonin, and eventually of pinoline and Deep Breathing Techniques to - Meditation - (Ajna) Chakra. Pinoline is a methoxylated tryptoline (5-methoxytryptoline) long claimed to be produced in the Aluminium toxicity causes an increase in lipid peroxidation, with most damage occurring in the brain. Lipopolysaccharide is produced by Gram-negative bacteria and stimulates the production of free radicals which in turn. Pinoline also resonates with the very pulse of life 8 cycles per second, the pulse the .. and hence there is an increased production of Meltaonin and Pinoline.pinoline powder
Melatonin is then converted in small amounts to pinoline. Production of melatonin is inhibited by light on the retina and then increases in Melatonin also seems to boost the immune system and slow the aging process. hyde (MDA) plus 4-hydroxyalkenals (4-HDA) production as a reflection of lipid peroxidation. Below .. melatonin did not improve the activity of pinoline in. increases in length during the sleep cycle, often . REMS. Pinoline increases brain serotonin levels, production of psychedelic compounds to account.
The pineal gland starts to increase the production of 'pinoline', whereby a greater fluidity of thought and healing of the body starts to occur. (1) Pinoline and melatonin are both structurally related to serotonin .. 5-HT1A and 5-HT2 is known to increase the neurogenesis rate in adult rat brain. The production of H2O2 catalyzed by MAO isoforms was detected using. This "Third Eye,” in the center of the brain, is implicated in the production of endogenous .. DMT with Pinoline increases brain activation, and with its cousin the. SNP increased MDA + 4-HDA and carbonyl contents production in brain homogenates Keywords: Melatonin; Pinoline; Nitric oxide; Lipid peroxidation; Protein. Therefore, increased production of endogenous KYNA might (similar to exogenous antagonist, MK) inhibit NAS biosynthesis and contribute to.
Request PDF on ResearchGate | Antioxidant activity of pinoline analogues in the replacement of this methoxy by an Et side chain increased the antioxidant. Aging is associated with increased production of reactive oxygen species .. Pinoline and N-acetylserotonin reduce glutamate-induced lipid. Pinoline, 6-methoxy-1,2,3,4-tetrahydro-β-carboline, is a serotonin analog have impaired or deficient CYP2D6 activity, they may have increased risk so that the rates of metabolite production were within the linear ranges. question the relevance of the neuroendocrine production of pinoline. . nitrogen in γ-position abolished the binding to 5-HT1AR receptors, but increased the.
Anti-NMDA receptor encephalitis is a severe encephalopathic autoimmune disease, which affects mainly young women with ovarian teratoma, but also women without tumors, men and children. First described in 2007, it is a currently still widely under diagnosed disease entity (J. Dalmau et al., 2008, Lancet Neurol 7(12): 1091-1098).N-Methyl-D-Aspartic Acid
Diagnosis of anti-NMDA receptor encephalitis is based on the detection of highly specific autoantibodies directed against glutamate receptors of type NMDA in serum or cerebrospinal fluid. These autoantibodies are detected with high sensitivity and specificity in indirect immunofluorescence using a human recombinant cell line expressing the major target antigen (receptor subunit NR1). The determination of antibodies against glutamate receptors (type NMDA) is of high significance in patients with encephalitis where no pathogen has been detected, as well as in suspected cases of limbic encephalitis. The new cell substrate can be combined with various tissue substrates that are relevant for differential diagnostics (e.g. hippocampus and cerebellum) as BIOCHIP Mosaics, allowing the detection of further autoantibodies associated with limbic encephalitis (e.g. anti-VGKC antibodies, anti-AMPA receptor antibodies)
As we watch the 2016 Rio Olympic Games with the Russian doping scandal looming in the rearview mirror the notion that noopept could be the next big banned substance in sport after meldonium is interesting on its own. However, when one considers that both substances appear to be sold as medication in Russia, and that many of the meldonium findings early this year involved Russian athletes, the intrigue gets deeper. Because noopept is prevalent in the supplement marketplace around the world, if it is the next clandestine doping agent the potential issue would expand well beyond Russia.
A comparison between the substance noopept and meldonium supports our theory. Meldonium, which is suggested to improve blood flow, is approved for use as anti-ischemia medication in Eastern Europe and Russia. It is usually used to treat heart disease. Although clearly popular with athletes, based on the hundreds of adverse analytical findings for the drug in early 2016, meldonium is not commonly found as a dietary supplement, at least not yet.
Meanwhile, noopept, is patented by JSC LEKKO Pharmaceuticals, a Russian pharmaceutical company, in both the U.S. and Russia. It is commonly sold as a dietary supplement in the nootropic category around the world, but appears to be sold as a medication in Russia and Eastern Europe. Noopept is being studied for its potential to alleviate Alzheimer’s symptoms and treat other brain disorders. It is not an approved drug in the U.S.
Noopept does not appear to be a controlled substance in the U.S. or other countries, or at least that is what some nootropic sites claim. That does not mean, however, it would be legal to sell as a supplement. It would likely qualify as an unapproved drug according to the U.S. FDA, or other international equivalents. As such, it may be OK to sell for research purposes, but not as a supplement marketed for human consumption. Given that noopept was patented in 1996, was not in the food supply prior to 1994, and is synthetic, it does not appear to qualify as a legal dietary supplement ingredient in the U.S., according to DSHEA (the Dietary Supplement Health and Education Act of 1994).
Despite noopept being a dubious, if not illegal, supplement ingredient, it is commonly found packaged as a supplement and is available online at a wide range of distributors including Amazon.com and Jet.com. Based on its prevalence in dietary supplements and on message boards, it seems it has become quite popular. With discussion on ‘The Worlds Most Trusted Anabolic Website,’ as far back as 2007, it appears folks that track performance-enhancing compounds have known about it for a number of years.
In fact, noopept has become so popular that even Reddit, who thankfully realizes the concern, has a note on noopept in ‘New Rules in Regards to Illegal/Dangerous Compounds.’ The note describes that, “synthetic drugs (not DSHEA compliant) that have too little information on them to assess toxicity (Ex. Noopept or PRL-8-53)…, are in the grey area.”